Predictive factors associated with three years of response to HbA1c goals with exenatide QW or insulin glargine: Post‐hoc analysis of the DURATION‐3 study

2019 ◽  
Vol 21 (4) ◽  
pp. 1049-1053
Author(s):  
Bruno Guerci ◽  
Michael E. Trautmann ◽  
Tim Lin ◽  
Elise Hardy ◽  
Sunder Raj D. Mudaliar
Keyword(s):  
Insulin Glargine ◽  
Predictive Factors ◽  
Post Hoc Analysis ◽  
Factors Associated ◽  
Exenatide Qw ◽  
Post Hoc

scholarly journals Similar glycaemic control and risk of hypoglycaemia with patient- versus physician-managed titration of insulin glargine 300 U/mL across subgroups of patients with T2DM: a post hoc analysis of ITAS

2021 ◽  
Author(s):  
Andrea Giaccari ◽  
R. C. Bonadonna ◽  
R. Buzzetti ◽  
G. Perseghin ◽  
D. Cucinotta ◽  
...  
Keyword(s):  
Glycaemic Control ◽  
Insulin Glargine ◽  
Patient Characteristics ◽  
Efficacy And Safety ◽  
Clinical Trial Registration ◽  
Post Hoc Analysis ◽  
Almost All ◽  
Antihyperglycaemic Drugs ◽  
Post Hoc ◽  
Patient Subgroups

Abstract Aims The Italian Titration Approach Study (ITAS) demonstrated comparable HbA1c reductions and similarly low hypoglycaemia risk at 6 months in poorly controlled, insulin-naïve adults with T2DM who initiated self- or physician-titrated insulin glargine 300 U/mL (Gla-300) in the absence of sulphonylurea/glinide. The association of patient characteristics with glycaemic and hypoglycaemic outcomes was assessed. Methods This post hoc analysis investigated whether baseline patient characteristics and previous antihyperglycaemic drugs were associated with HbA1c change and hypoglycaemia risk in patient- versus physician-managed Gla-300 titration. Results HbA1c change, incidence of hypoglycaemia (any type) and nocturnal rates were comparable between patient- and physician-managed arms in all subgroups. Hypoglycaemia rates across subgroups (0.03 to 3.52 events per patient-year) were generally as low as observed in the full ITAS population. Small increases in rates of 00:00–pre-breakfast and anytime hypoglycaemia were observed in the ≤ 10-year diabetes duration subgroup in the patient- versus physician-managed arm (heterogeneity of effect; p < 0.05). Conclusions Comparably fair glycaemic control and similarly low hypoglycaemia risk were achieved in almost all patient subgroups with patient- versus physician-led Gla-300 titration. These results reinforce efficacy and safety of Gla-300 self-titration across a range of phenotypes of insulin-naïve people with T2DM. Clinical trial registration EudraCT 2015-001167-39

scholarly journals Predictive factors of the pharmacological action of tolvaptan in patients with liver cirrhosis: a post hoc analysis

2016 ◽  
Vol 52 (2) ◽  
pp. 229-236 ◽  
Author(s):  
Isao Sakaida ◽  
Shuji Terai ◽  
Koji Nakajima ◽  
Yoshiyuki Shibasaki ◽  
Sayaka Tachikawa ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Predictive Factors ◽  
Pharmacological Action ◽  
Post Hoc Analysis ◽  
Post Hoc
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