scholarly journals The retinopathy‐derived glycated hemoglobin threshold of 6.5% for type 2 diabetes also captures the risk of diabetic nephropathy in NHANES

Author(s):  
Stephen L Atkin ◽  
Alexandra E Butler ◽  
Steven C Hunt ◽  
Eric S. Kilpatrick

2021 ◽  
Vol 15 (7) ◽  
pp. 1974-1977
Author(s):  
Vitasari Indriani ◽  
Wahyu Siswandari ◽  
Andreas . ◽  
Tri Lestari

Background: Diabetes mellitus has strong correlation with end stage renal disease (ESRD) and responsible for 30-40% of all ESRD cases.This study is focused on assessing the diabetic nephropathy status in patients with type 2 diabetes. Glycated hemoglobin levels over therapeutic targets (>7%) had two times the risk of complications for diabetic nephropathy, ISN recommends the use of microalbuminuria and urinary albumin creatinine ratio (UACR) for early detection of diabetic nephropathy and for monitoring therapy. Objective: This study was conducted to prove the correlation between Glycated Albumin with microalbuminuria and UACR in type 2 diabetes. Methods: Cross sectional study was done in70diabetic type 2 patients who attended PROLANIS program in Primary Health Care from May to November 2018.Detailed medical history including the diabetes duration and relevant clinical examination like FBS, PPBS, HbA1c, urinary creatinineand urinary microalbumin were recorded in each patient.Significance is assessed at 5% level of significance. Results: This study obtained the mean age of the study population was 51.89 ± 6.78 years with female preponderance (51.1%).Mean FBS, PPBS, HbA1c, duration of diabetes, blood pressure, microalbuminuria and urinary creatinine were182.51 ± 74.63 mg/dL, 186.25±26.72 mg/dL, 8.8 ± 1.83%, 9.37±5.96 years, 138.44±14, 13/84.44±19.25 mmHg,30.32±3.2 mg/day and 1.33±0.64 mg/dl respectively.Microalbuminuria (r=0.91, p≤0.05) and UACR (r=0.67, p≤0.05) were positively associated with glycated hemoglobin. Conclusion: It can be concluded that microalbuminuria level and ACR increase in line with the worsening of glycosylated hemoglobin and diabetes duration. Keywords: Albumin Creatinine Ratio; Diabetes; HbA1c; Microalbuminuria



ABOUTOPEN ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. 69-72
Author(s):  
Andrea Da Porto

We report the case of a 75-year old patient affected by type 2 diabetes for about 20 years, treated for a prolonged period with insulin secretagogues. He is also affected by arterial hypertension, obesity and incipient diabetic nephropathy and had suffered a cardiovascular event. He was referred to us by his GP to verify his high values of glycated hemoglobin (HbA1c) and for an excessive weight increase (Diabetology)





Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2306-PUB
Author(s):  
MAMI YOSHIDA ◽  
AI YOSHIDA ◽  
ERIKO OH ◽  
NAOMUNE YAMAMOTO ◽  
EUN SASAKI ◽  
...  




2021 ◽  
pp. 239936932098478
Author(s):  
Joana Marques ◽  
Patrícia Cotovio ◽  
Mário Góis ◽  
Helena Sousa ◽  
Fernando Nolasco

Diabetic nephropathy is a well known complication of diabetes mellitus and the leader cause of end -stage renal disease worldwide. Nonetheless, other forms of renal involvement can occur in diabetic population. Since it has prognostic and therapeutic implications, differentiating non-diabetic renal disease from diabetic nephropathy is of great importance. We report an 80-year-old man with well-controlled type 2 diabetes mellitus and hypertension, who presented with rapid deterioration of renal function, nephrotic proteinuria, microscopic hematuria and leukocyturia. The atypical clinical presentation prompted us to perform a kidney biopsy. A diagnosis of proliferative glomerulonephritis with monoclonal immunoglobulin deposits (light chain only variant) was made, with however some chronic histological aspects which made us took a conservative therapeutic attitude. We emphasize that other causes of chronic proteinuric kidney disease should be considered in patients with type 2 diabetes mellitus, based on clinical suspicion, absence of other organ damage and mostly if an atypical presentation is seen. We review the spectrum of monoclonal gammopathies of renal significance, focusing on this rare and newly describe entity.



Gene ◽  
2021 ◽  
Vol 774 ◽  
pp. 145426
Author(s):  
Swetha Chikoti ◽  
Umme Najiya Mahwish ◽  
Sree Bhushan Raju ◽  
Sumanlatha Gaddam ◽  
Parveen Jahan


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