Keratitis‐ichthyosis‐deafness syndrome: Phenotypic heterogeneity and treatment perspective of patients with p. Asp50Asn GJB2 mutation

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Tina Asgari ◽  
Mahtab Naji ◽  
Parvin Mansouri ◽  
Hamidreza Mahmoudi ◽  
Masoud Zabihi ◽  
...  
Keyword(s):  
Phenotypic Heterogeneity ◽  
Gjb2 Mutation

Phenotypic heterogeneity associated with proglucagon-expressing tumours is due to differential processing and secretion of proglucagon-derived peptides

2015 ◽  
Author(s):  
Ben Challis ◽  
Nicolai Albrechtsen ◽  
Vishakha Bansiya ◽  
Keith Burling ◽  
Peter Barker ◽  
...  
Keyword(s):  
Phenotypic Heterogeneity ◽  
Differential Processing

PHENOTYPIC HETEROGENEITY IN PAPILLON-LEFÈVRE SYNDROME

2016 ◽  
Author(s):  
Laura Perez
Keyword(s):  
Phenotypic Heterogeneity

PHENOTYPIC HETEROGENEITY OF CARDIAC MACROPHAGES DURING WOUND HEALING FOLLOWING MYOCARDIAL INFARCTION: PERSPECTIVES IN CLINICAL RESEARCH

2018 ◽  
Vol 33 (2) ◽  
pp. 70-76 ◽  
Author(s):  
A. E. Gombozhapova ◽  
Yu. V. Rogovskaya ◽  
M. S. Rebenkova ◽  
J. G. Kzhyshkowska ◽  
V. V. Ryabov
Keyword(s):  
Myocardial Infarction ◽  
Wound Healing ◽  
Cardiac Remodeling ◽  
Phenotypic Heterogeneity ◽  
Macrophage Infiltration ◽  
Myocardial Regeneration ◽  
Control Group ◽  
M2 Macrophage ◽  
Inflammatory Phase ◽  
Regenerative Phase

Purpose. Myocardial regeneration is one of the most ambitious goals in prevention of adverse cardiac remodeling. Macrophages play a key role in transition from inflammatory to regenerative phase during wound healing following myocardial infarction (MI). We have accumulated data on macrophage properties ex vivo and in cell culture. However, there is no clear information about phenotypic heterogeneity of cardiac macrophages in patients with MI. The purpose of the project was to assess cardiac macrophage infiltration during wound healing following myocardial infarction in clinical settings taking into consideration experimental knowledge.Material and Methods. The study included 41 patients with fatal MI type 1. In addition to routine analysis, macrophages infiltration was assessed by immunohistochemistry. We used CD68 as a marker for the cells of the macrophage lineage, while CD163, CD206, and stabilin-1 were considered as M2 macrophage biomarkers. Nine patients who died from noncardiovascular causes comprised the control group.Results. The intensity of cardiac macrophage infiltration was higher during the regenerative phase than during the inflammatory phase. Results of immunohistochemical analysis demonstrated the presence of phenotypic heterogeneity of cardiac macrophages in patients with MI. We noticed that numbers of CD68+, CD163+, CD206+, and stabilin-1+ macrophages depended on MI phase.Conclusion. Our study supports prospects for implementation of macrophage phenotyping in clinic practice. Improved understanding of phenotypic heterogeneity might become the basis of a method to predict adverse cardiac remodeling and the first step in developing myocardial regeneration target therapy.

Phenotypic Heterogeneity of Rat Arterial Smooth Muscle Cell Clones

1996 ◽  
Vol 16 (6) ◽  
pp. 815-820 ◽  
Author(s):  
Marie-Luce Bochaton-Piallat ◽  
Patricia Ropraz ◽  
Françoise Gabbiani ◽  
Giulio Gabbiani
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Phenotypic Heterogeneity ◽  
Arterial Smooth Muscle Cell ◽  
Arterial Smooth Muscle ◽  
Cell Clones
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