Successful therapy of disseminated patch‐type granuloma annulare with upadacitinib in a patient with rheumatoid arthritis

Subcutaneous nodules, composed of necrotic collagen surrounded by chronic inflammatory cells, occur in about 20% of individuals with rheumatoid arthritis, 10% of those with acute rheumatic fever, and 25% of children with granuloma annulare. Similar subcutaneous lesions indistinguishable from rheumatoid nodules may appear in children who do not develop other stigmata of disease. Mesara and ous lesions of granuloma annulare. Therefore, they felt that, in children, these nodules probably represented a clinical variant of granuloma annulare. Beatty3 described nine children aged 11 days to 9 years with nodules on the scalp, ulnar aspect of the arm, dorsum of the foot, and palm of the hand which appeared histologically to be rheumatoid nodules.

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Granuloma annulare development in a patient with rheumatoid arthritis treated with tocilizumab: case-based review

Rheumatology International ◽

10.1007/s00296-018-4212-0 ◽

2018 ◽

Vol 39 (2) ◽

pp. 353-357 ◽

Cited By ~ 5

Author(s):

Eleftherios Pelechas ◽

Alexandra Papoudou-Bai ◽

Paraskevi V. Voulgari ◽

Alexandros A. Drosos

Keyword(s):

Rheumatoid Arthritis ◽

Granuloma Annulare ◽

Case Based

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Successful Therapy of Rheumatoid Arthritis With Rituximab

JCR Journal of Clinical Rheumatology ◽

10.1097/01.rhu.0000111316.59676.db ◽

2004 ◽

Vol 10 (1) ◽

pp. 28-32 ◽

Cited By ~ 7

Author(s):

Heather Kramm ◽

Karen E. Hansen ◽

Eric Gowing ◽

Alan Bridges

Keyword(s):

Rheumatoid Arthritis ◽

Successful Therapy

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Granuloma annulare, patch type

Dermatology Online Journal ◽

10.5070/d35z4869nk ◽

2008 ◽

Vol 14 (5) ◽

Author(s):

Frank C Victor ◽

Stephanie Mengden

Keyword(s):

Granuloma Annulare ◽

Patch Type

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Patch-type granuloma annulare: a case report

Medicina (Ribeirao Preto Online) ◽

10.11606/issn.2176-7262.v50i2p130-133 ◽

2017 ◽

Vol 50 (2) ◽

pp. 130

Author(s):

Rafael Tomaz Gomes ◽

Jenifer Greice Schiavetti Ribeiro Balizardo ◽

Carlos Zelandi Filho ◽

Luiza Vasconcelos Schaefe

Keyword(s):

Case Report ◽

Granuloma Annulare ◽

Patch Type

O granuloma anular (GA) é uma condição benigna, autolimitada e de etiologia desconhecida. Clinicamente é caracterizado por pápulas eritematosas anulares nas extremidades. Do ponto de vista histológico, observa-se a formação de granulomas com colágeno degenerado em sua porção central e depósito de mucina. O paciente deste caso clínico foi diagnosticado com uma variante rara de granuloma anular, na sua forma macular. A lesão se apresentava como máculas eritematosas assintomáticas na porção superior das coxas. Nos cortes histológicos, o quadro era compatível com GA do tipo intersticial. Neste trabalho enfatiza-se a necessidade de um elevado índice de suspeição clínica para o diagnóstico de GA macular e a confirmação só poderá ser alcançada através do estudo histopatológico

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Patch-Type Granuloma Annulare: A Therapeutic and Diagnostic Challenge

10.47363/jdmrs/2020(1)111 ◽

2020 ◽

pp. 1-2

Author(s):

Renata Indelicato Zac ◽

◽

Luiz Fernando de Oliveira Santana ◽

Adilson da Costa ◽

◽

...

Keyword(s):

Mycosis Fungoides ◽

Granuloma Annulare ◽

Inflammatory Disorder ◽

Diagnostic Challenge ◽

Patch Type ◽

Chronic Inflammatory Disorder

Granuloma annulare (GA) is a common, benign, chronic inflammatory disorder, which is characterized by grouped papules in an annular shape. It has been described in several clinical subtypes, including localized, generalized, subcutaneous, perforating, and erythematous. Herein, we report a 65-year-old woman with pruritic erythematous patches, mimicking mycosis fungoides, which occurred on the abdomen and thights and showed typical clinical and histopatologic findings of erythematous GA

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Resolution of patch-type granuloma annulare lesions after biopsy

Journal of the American Academy of Dermatology ◽

10.1067/mjd.2002.118344 ◽

2002 ◽

Vol 46 (3) ◽

pp. 426-429 ◽

Cited By ~ 31

Author(s):

Nikki A. Levin ◽

James W. Patterson ◽

Luke L. Yaoc ◽

Barbara B. Wilson

Keyword(s):

Granuloma Annulare ◽

Patch Type

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Cutaneous borreliosis: An insidious mimicker of patch‐type granuloma annulare

Journal of Cutaneous Pathology ◽

10.1111/cup.13760 ◽

2020 ◽

Vol 47 (9) ◽

pp. 876-878

Author(s):

Andrea Saggini ◽

Lorenzo Cerroni

Keyword(s):

Granuloma Annulare ◽

Patch Type

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Granuloma annulare induced by anti-tumour necrosis factor therapy

Annals of the Rheumatic Diseases ◽

10.1136/ard.2007.075663 ◽

2007 ◽

Vol 67 (4) ◽

pp. 567-570 ◽

Cited By ~ 62

Author(s):

P V Voulgari ◽

T E Markatseli ◽

S A Exarchou ◽

A Zioga ◽

A A Drosos

Keyword(s):

Rheumatoid Arthritis ◽

Tumour Necrosis Factor ◽

Tumour Necrosis ◽

Skin Lesions ◽

Granuloma Annulare ◽

First Year ◽

Potential Development ◽

Factor Therapy ◽

Tnf Inhibition ◽

Necrosis Factor

Objective:To describe granuloma annulare (GA) skin lesion development in patients during anti-tumour necrosis factor (TNF) therapy.Methods:199 patients with rheumatoid arthritis and 127 suffering from spondyloarthropathies treated with anti-TNF antagonists were analysed to identify skin lesions suggesting GA.Results:Nine cases of GA during anti-TNF therapy (123 treated with infliximab, 57 with adalimumab and 17 with etanercept) for rheumatoid arthritis were identified. Two have been treated with infliximab, six with adalimumab and one with etanercept, and here the development of GA was 4.5%. No patient with spondyloarthropathies developed such skin lesions. All patients developed the generalised form of GA. None had or developed diseases, or conditions known to be associated with GA. In seven patients the skin eruptions developed during the first year of anti-TNF treatment, while they developed in two patients during the second year. Two patients had to stop anti-TNF therapy due to the extent of skin lesions. All patients responded well to the local corticosteroid therapy.Conclusions:Our series strongly supports a link between TNF inhibition and the development of GA in some patients. When dealing with patients on these agents physicians should be aware of possible adverse events and the potential development of such complications.

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