Role of Three-Dimensional Speckle Tracking Echocardiography in the Quantification of Myocardial Iron Overload in Patients with Beta-Thalassemia Major

2016 ◽  
Vol 33 (9) ◽  
pp. 1361-1367 ◽  
Author(s):  
Shu-juan Li ◽  
Yu-yan Hwang ◽  
Shau-yin Ha ◽  
Godfrey C.F. Chan ◽  
Amanda S.P. Mok ◽  
...  
Keyword(s):  
Iron Overload ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Three Dimensional ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Myocardial Iron ◽  
Beta Thalassemia Major

scholarly journals How Early Can Myocardial Iron Overload Occur in Beta Thalassemia Major?

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85379 ◽  
Author(s):  
Gaohui Yang ◽  
Rongrong Liu ◽  
Peng Peng ◽  
Liling Long ◽  
Xinhua Zhang ◽  
...  
Keyword(s):  
Iron Overload ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Myocardial Iron ◽  
Beta Thalassemia Major

Myocardial deformation in iron overload cardiomyopathy: speckle tracking imaging in a beta-thalassemia major population

2017 ◽  
Vol 12 (6) ◽  
pp. 799-809 ◽  
Author(s):  
Luca Antonio Felice Di Odoardo ◽  
Marianna Giuditta ◽  
Elena Cassinerio ◽  
Alberto Roghi ◽  
Patrizia Pedrotti ◽  
...  
Keyword(s):  
Iron Overload ◽  
Speckle Tracking ◽  
Thalassemia Major ◽  
Myocardial Deformation ◽  
Beta Thalassemia ◽  
Speckle Tracking Imaging ◽  
Beta Thalassemia Major ◽  
Iron Overload Cardiomyopathy

scholarly journals Three Dimensional Speckle Tracking Echocardiography (3D-STE) for Early Detection of Subtle Myocardial Deformation Dysfunction in Thalassemic Patients

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 2158-2158
Author(s):  
Hala Mounir Mohamed Moustafa Agha ◽  
Antoine AbdelMassih ◽  
Mohamed Youssef Abd El Rahman ◽  
Ornella Milanesi, ◽  
Biagio Castaldi ◽  
...  
Keyword(s):  
Early Detection ◽  
Speckle Tracking ◽  
Speckle Tracking Echocardiography ◽  
Three Dimensional ◽  
Left Ventricular ◽  
Myocardial Deformation ◽  
Left Ventricular Ejection ◽  
Myocardial Iron ◽  
Ventricular Ejection Fraction ◽  
Control Subjects

Abstract Background: Among patients with beta-thalassemia early detection of transfusion-induced myocardial iron loading and its intervention with aggressive chelation therapy may delay or reverse heart failure. Three dimensional speckle tracking echocardiography (3D-STE) is a novel tool that may early detect myocardial affection in these patients. Methods: Thirty-two thalassemic patients with a mean age of 18.1± 7.03 years and 30 aged matched healthy control subjects have been included in the study. Patients have been recruited from pediatric hematology clinics in both Cairo University, Egypt (n=18) and Padova University, Italy (n=14). 3D-STE was performed to all patients and control subjects in addition to the myocardial relaxometry T2* by cardiac MRI. Results: The left ventricular ejection fraction (LVEF) derived from 3D echocardiography among the studied thalassemia patients was within normal range 62.5± 5.6%. Compared to the normal subjects, thalassemia patients had a statistical significant reduction of the left ventricular global longitudinal strain (-16.81± 0.93% vs -18.76 ± 1.12 %, p=0.001), the left ventricular global circumferential strain (-10.56 ± 0.61% vs -11.83 ± 0.71 %, p=0.001 ) and the left ventricular global area strain (-20.13 ±1.18% vs -22.48 ±,1.29 %, p=0.001). No statistical significant correlation was found between the severity of myocardial iron overload measured by T2* and the measured left ventricular global strain. Conclusion: In asymptomatic thalassemia patients with preserved left ventricular global systolic function 3D-STE derived strain can detect early subtle myocardial dysfunction. The observed subtle myocardial deformation dysfunction is not related to the extent of myocardial iron deposition. Disclosures No relevant conflicts of interest to declare.

GlutathioneS-transferase gene polymorphism: Relation to cardiac iron overload in Egyptian patients with Beta Thalassemia Major

Hematology ◽  
2015 ◽  
Vol 21 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Galila M. Mokhtar ◽  
Eman M. Sherif ◽  
Nevin M. Habeeb ◽  
Abeer A. Abdelmaksoud ◽  
Eman A. El-Ghoroury ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Iron Overload ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Cardiac Iron ◽  
Beta Thalassemia Major ◽  
Transferase Gene ◽  
Egyptian Patients ◽  
Cardiac Iron Overload

scholarly journals Atrial Fibrillation and Beta Thalassemia Major: The Predictive Role of the 12-lead Electrocardiogram Analysis

2014 ◽  
Vol 14 (3) ◽  
pp. 121-132 ◽  
Author(s):  
Vincenzo Russo ◽  
Anna Rago ◽  
Bruno Pannone ◽  
Maria Carolina Mayer ◽  
Anna Spasiano ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Thalassemia Major ◽  
Beta Thalassemia ◽  
Beta Thalassemia Major ◽  
Predictive Role
Sign in / Sign up

Export Citation Format

Share Document