Initial memory consolidation and the synaptic tagging and capture hypothesis

2020 ◽  
Author(s):  
Kosuke Okuda ◽  
Kristoffer Højgaard ◽  
Lucia Privitera ◽  
Gülberk Bayraktar ◽  
Tomonori Takeuchi
Keyword(s):  
Memory Consolidation ◽  
Synaptic Tagging And Capture

scholarly journals Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis

2015 ◽  
Vol 2015 ◽  
pp. 1-21 ◽  
Author(s):  
Diego Moncada ◽  
Fabricio Ballarini ◽  
Haydée Viola
Keyword(s):  
Experimental Data ◽  
Memory Consolidation ◽  
Electrical Stimulus ◽  
Memory Formation ◽  
Synaptic Specificity ◽  
Molecular Machinery ◽  
Synaptic Changes ◽  
Plastic Changes ◽  
Synaptic Tagging And Capture ◽  
Related Proteins

Similar molecular machinery is activated in neurons following an electrical stimulus that induces synaptic changes and after learning sessions that trigger memory formation. Then, to achieve perdurability of these processes protein synthesis is required for the reinforcement of the changes induced in the network. The synaptic tagging and capture theory provided a strong framework to explain synaptic specificity and persistence of electrophysiological induced plastic changes. Ten years later, the behavioral tagging hypothesis (BT) made use of the same argument, applying it to learning and memory models. The hypothesis postulates that the formation of lasting memories relies on at least two processes: the setting of a learning tag and the synthesis of plasticity related proteins, which once captured at tagged sites allow memory consolidation. BT explains how weak events, only capable of inducing transient forms of memories, can result in lasting memories when occurring close in time with other behaviorally relevant experiences that provide proteins. In this review, we detail the findings supporting the existence of BT process in rodents, leading to the consolidation, persistence, and interference of a memory. We focus on the molecular machinery taking place in these processes and describe the experimental data supporting the BT in humans.

scholarly journals Memory consolidation and improvement by synaptic tagging and capture in recurrent neural networks

2020 ◽  
Author(s):  
Jannik Luboeinski ◽  
Christian Tetzlaff
Keyword(s):  
Neural Network ◽  
Synaptic Plasticity ◽  
Memory Consolidation ◽  
Recurrent Neural Networks ◽  
Neural Circuits ◽  
Memory Recall ◽  
Spiking Neural Network ◽  
Memory Enhancement ◽  
Biological Principle ◽  
Synaptic Tagging And Capture

AbstractThe synaptic-tagging-and-capture (STC) hypothesis formulates that at each synapse the concurrence of a tag with protein synthesis yields the maintenance of changes induced by synaptic plasticity. This hypothesis provides a biological principle underlying the synaptic consolidation of memories that is not verified for recurrent neural circuits. We developed a theoretical model integrating the mechanisms underlying the STC hypothesis with calcium-based synaptic plasticity in a recurrent spiking neural network. In the model, calcium-based synaptic plasticity yields the formation of strongly interconnected cell assemblies encoding memories, followed by consolidation through the STC mechanisms. Furthermore, we find that the STC mechanisms have an up to now undiscovered effect on memories – with the passage of time they modify the storage of memories, such that after several hours memory recall is significantly improved. This kind of memory enhancement can provide a new principle for storing information in biological and artificial neural circuits.

scholarly journals Memory consolidation and improvement by synaptic tagging and capture in recurrent neural networks

2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Jannik Luboeinski ◽  
Christian Tetzlaff
Keyword(s):  
Synaptic Plasticity ◽  
Memory Consolidation ◽  
Recurrent Neural Networks ◽  
Neural Circuits ◽  
Time Dependent ◽  
Memory Recall ◽  
Spiking Neural Network ◽  
Biological Principle ◽  
Synaptic Tagging And Capture ◽  
First Time

AbstractThe synaptic-tagging-and-capture (STC) hypothesis formulates that at each synapse the concurrence of a tag with protein synthesis yields the maintenance of changes induced by synaptic plasticity. This hypothesis provides a biological principle underlying the synaptic consolidation of memories that is not verified for recurrent neural circuits. We developed a theoretical model integrating the mechanisms underlying the STC hypothesis with calcium-based synaptic plasticity in a recurrent spiking neural network. In the model, calcium-based synaptic plasticity yields the formation of strongly interconnected cell assemblies encoding memories, followed by consolidation through the STC mechanisms. Furthermore, we show for the first time that STC mechanisms modify the storage of memories such that after several hours memory recall is significantly improved. We identify two contributing processes: a merely time-dependent passive improvement, and an active improvement during recall. The described characteristics can provide a new principle for storing information in biological and artificial neural circuits.

Positive Arousal Enhances the Consolidation of Item Memory

2015 ◽  
Vol 74 (2) ◽  
pp. 91-104 ◽  
Author(s):  
Bo Wang
Keyword(s):  
Episodic Memory ◽  
Memory Consolidation ◽  
Source Memory ◽  
Emotional Arousal ◽  
Theoretical Models ◽  
Memory Test ◽  
Learning Phase ◽  
Item Memory ◽  
Memory Tests ◽  
Immediate Memory

Emotional arousal induced after learning has been shown to modulate memory consolidation. However, it is unclear whether the effect of postlearning arousal can extend to different aspects of memory. This study examined the effect of postlearning positive arousal on both item memory and source memory. Participants learned a list of neutral words and took an immediate memory test. Then they watched a positive or a neutral videoclip and took delayed memory tests after either 25 minutes or 1 week had elapsed after the learning phase. In both delay conditions, positive arousal enhanced consolidation of item memory as measured by overall recognition. Furthermore, positive arousal enhanced consolidation of familiarity but not recollection. However, positive arousal appeared to have no effect on consolidation of source memory. These findings have implications for building theoretical models of the effect of emotional arousal on consolidation of episodic memory and for applying postlearning emotional arousal as a technique of memory intervention.

Sign in / Sign up

Export Citation Format

Share Document