A Bionic Spatial Cognition Model and Method for Robots Based on the Hippocampus Mechanism

The hippocampus and its accessory are the main areas for spatial cognition. It can integrate paths and form environmental cognition based on motion information and then realize positioning and navigation. Learning from the hippocampus mechanism is a crucial way forward for research in robot perception, so it is crucial to building a calculation method that conforms to the biological principle. In addition, it should be easy to implement on a robot. This paper proposes a bionic cognition model and method for mobile robots, which can realize precise path integration and cognition of space. Our research can provide the basis for the cognition of the environment and autonomous navigation for bionic robots.

Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia—Relevance for Mental Diseases

The heteroreceptor complexes present a novel biological principle for signal integration. These complexes and their allosteric receptor–receptor interactions are bidirectional and novel targets for treatment of CNS diseases including mental diseases. The existence of D2R-5-HT2AR heterocomplexes can help explain the anti-schizophrenic effects of atypical antipsychotic drugs not only based on blockade of 5-HT2AR and of D2R in higher doses but also based on blocking the allosteric enhancement of D2R protomer signaling by 5-HT2AR protomer activation. This research opens a new understanding of the integration of DA and 5-HT signals released from DA and 5-HT nerve terminal networks. The biological principle of forming 5-HT and other heteroreceptor complexes in the brain also help understand the mechanism of action for especially the 5-HT hallucinogens, including putative positive effects of e.g., psilocybin and the indicated prosocial and anti-stress actions of MDMA (ecstasy). The GalR1-GalR2 heterodimer and the putative GalR1-GalR2-5-HT1 heteroreceptor complexes are targets for Galanin N-terminal fragment Gal (1–15), a major modulator of emotional networks in models of mental disease. GPCR-receptor tyrosine kinase (RTK) heteroreceptor complexes can operate through transactivation of FGFR1 via allosteric mechanisms and indirect interactions over GPCR intracellular pathways involving protein kinase Src which produces tyrosine phosphorylation of the RTK. The exciting discovery was made that several antidepressant drugs such as TCAs and SSRIs as well as the fast-acting antidepressant drug ketamine can directly bind to the TrkB receptor and provide a novel mechanism for their antidepressant actions. Understanding the role of astrocytes and their allosteric receptor–receptor interactions in modulating forebrain glutamate synapses with impact on dorsal raphe-forebrain serotonin neurons is also of high relevance for research on major depressive disorder.

Memory consolidation and improvement by synaptic tagging and capture in recurrent neural networks

The synaptic-tagging-and-capture (STC) hypothesis formulates that at each synapse the concurrence of a tag with protein synthesis yields the maintenance of changes induced by synaptic plasticity. This hypothesis provides a biological principle underlying the synaptic consolidation of memories that is not verified for recurrent neural circuits. We developed a theoretical model integrating the mechanisms underlying the STC hypothesis with calcium-based synaptic plasticity in a recurrent spiking neural network. In the model, calcium-based synaptic plasticity yields the formation of strongly interconnected cell assemblies encoding memories, followed by consolidation through the STC mechanisms. Furthermore, we show for the first time that STC mechanisms modify the storage of memories such that after several hours memory recall is significantly improved. We identify two contributing processes: a merely time-dependent passive improvement, and an active improvement during recall. The described characteristics can provide a new principle for storing information in biological and artificial neural circuits.

Biological Origin of Egoism in Human Behavior

The article considers the biological principle of egoism in relation to human nature and the moral development of a person, criticism of the concepts of the selfishness of human nature. The different points of view of the professional psychologists are analyzed.

Memory consolidation and improvement by synaptic tagging and capture in recurrent neural networks

The synaptic-tagging-and-capture (STC) hypothesis formulates that at each synapse the concurrence of a tag with protein synthesis yields the maintenance of changes induced by synaptic plasticity. This hypothesis provides a biological principle underlying the synaptic consolidation of memories that is not verified for recurrent neural circuits. We developed a theoretical model integrating the mechanisms underlying the STC hypothesis with calcium-based synaptic plasticity in a recurrent spiking neural network. In the model, calcium-based synaptic plasticity yields the formation of strongly interconnected cell assemblies encoding memories, followed by consolidation through the STC mechanisms. Furthermore, we find that the STC mechanisms have an up to now undiscovered effect on memories – with the passage of time they modify the storage of memories, such that after several hours memory recall is significantly improved. This kind of memory enhancement can provide a new principle for storing information in biological and artificial neural circuits.

Å balansere mellom barnevernets prinsipper

The focus of this chapter is the potential conflicts between the values that are basic in the work of Norwegian child protection service. Such values are expressed in principles that serve as guidelines for judgement and decisions in the field. ‘The best interest of the child’ principle is held to be grounding. The ‘mildest intervention’ principle and the ‘biological’ principle are normally held to be at the core of how the best interest of the child is to be understood. Important in child protection work, is to interpret the principles, weigh them, and consider what implications they should have in specific cases. I argue that if, for some reason, one principle is ascribed too much weigh on the cost of others, the solution for the child might not be in its best interest. I highlight the importance of not only weighing the principles against each other, but also creating a coherent balance between the principles, people’s moral intuitions and the actual practices of the service. To this end, I suggest that John Rawls’s model called reflective equilibrium might be workable.

El estatus metateórico de ZFEL

In a recent book, McShea and Brandon argue that the observed diversity and complexity of life are explainable by a principle they call the “zero-force evolutionary law” or “ZFEL”. Although this principle would be implicit in many explanations given by biologists, it would have never been made explicit. Assuming that this idea is interesting, and that the authors are right, we will discuss the metatheoretical way in which they present said principle, as being a part of probability theory. This allows the authors to claim that probability theory provides the reductive basis for all evolutionary biology (given that they consider other principles, such as the principle of natural selection, as part of probability theory as well). We will defend, in accordance with them, that ZFEL is not a solely biological principle, but not because it is a part of probability theory, but rather because it is a specific version of the principle of common cause.

On the Biological Term “Gene” in the History of Science

Contemporary philosophy of science sets the origins of the predominantattributes of the term “gene” in the year 1900 when Gregor Mendel’s work was rediscovered. Yet it was the speculative biology of the second half of the 19th century that opened up the epistemic sphere for a new conception of heredity: heredity as the transmission of particulate, hereditable material units with a tendency for self-preservation. The then young discipline of biology dissociated its terminology from the preconceptions of natural philosophy. In the early 20th century, the postulated hereditary particles were associated with the chromosome and, at least in the 1940s, with nucleic acid: which was being stable and, at the same time, mutable, as well as capable of self-reproduction, self-selectivity, and memory. DNA epitomizes the perfect biological principle. But the most recent conception of the gene is not free from anthropomorphisms.