Long‐term survival outcomes and prognostic factors related to ruptured intracranial aneurysms: A comparison of surgical and endovascular options in a propensity‐score‐matched, nationwide, population‐based cohort study

AimTo determine if survival and hospital resource usage differ following traumatic brain injury (TBI) compared with head injury without neurological injury(HI).MethodsThis retrospective population-based cohort study included all 25 319 patients admitted to a Scottish NHS hospital from 1997–2015 with TBI. Participants were identified using previously validated ICD-10 based definitions. For comparison, all 194 049 HI cases were identified. Our main outcome measures were hazards of all-cause mortality after TBI, compared with HI, over 18 years follow-up period; and odds of mortality at one month post-injury. Number of days spent as inpatients and number of outpatient attendances per surviving month post-injury were used as measures of resource utilisation.ResultsThe adjusted odds ratio for mortality in the first month post-injury for TBI was 7.12 (95% confidence interval [CI] 6.73–7.52; p<0.001). For the remaining 18 year study period, the hazards of morality after TBI were 0.93 (CI 0.90–0.96; p<0.001). TBI was associated with 2.15 (CI 2.10–2.20; p<0.001) more days spent as inpatient and 1.09 times more outpatient attendances (CI 1.07–1.11; p<0.001) than HI.ConclusionsAlthough initial mortality following TBI is high, survivors of the first month can achieve comparable long-term survival to HI. However this is associated with increased utilisation of hospital services in the TBI group.

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Prognostic factors and long-term survival outcomes of thymic tumors

Current Thoracic Surgery ◽

10.26663/cts.2019.00015 ◽

2019 ◽

Vol 4 (2) ◽

pp. 81

Author(s):

Cemal Aker ◽

Cem Emrah Kalafat ◽

Celal Buğra Sezen ◽

Yasar Sonmezoglu ◽

Levent Cansever ◽

...

Keyword(s):

Prognostic Factors ◽

Survival Outcomes ◽

Term Survival ◽

Long Term Survival ◽

Thymic Tumors

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Severity of Complications and Long-Term Survival After Laparoscopic Total Gastrectomy With D2 Lymph Node Dissection for Advanced Gastric Cancer: A Propensity Score-Matched Study

Journal of Global Oncology ◽

10.1200/jgo.18.90500 ◽

2018 ◽

Vol 4 (Supplement 2) ◽

pp. 223s-223s

Author(s):

Z. Li

Keyword(s):

Gastric Cancer ◽

Propensity Score ◽

Independent Risk Factor ◽

Laparoscopic Total Gastrectomy ◽

Survival Outcomes ◽

Cancer Specific Survival ◽

Term Survival ◽

Long Term Survival ◽

D2 Lymph Node Dissection

Background: Increasing numbers of studies have shown that postoperative complication is a negative predictor of long-term survival outcomes in in various malignancies. However, the impact of severity of complications on long-term survival for patients with gastric cancer still remains unclear. Aim: This study aimed to explore the relationship between the severity of complications and long-term survival outcomes after laparoscopic total gastrectomy (LTG) for advanced gastric cancer (AGC). Methods: The study analyzed 571 patients with AGC who underwent LTG in a single institution between April 2008 and June 2015. Patients were divided into 2 groups based on the occurrence or absence of postoperative complications which were recorded using the Clavien-Dindo (C-D) classification. Long-term survival outcomes were compared between groups in the propensity score-matched cohort. Results: The groups were well balanced after the propensity score matched. The complication (C) group was associated with decreased 5-year cancer-specific survival (CSS) (65.1% vs 76.2%, P = 0.049). Subgroup analysis showed that the severe complication (C-D grade > II) group was associated with decreased 5-year overall survival (OS) (46.3% vs 65.9%, P = 0.042) and cancer-specific survival (CSS) (53.7% vs 74.4%, P = 0.030). However, a comparative analysis of 5-year OS and CCS showed no significant differences between the minor complication (C-D grade II) group and matched NC group (68.9% vs 72.2%, P = 0.578; 75.6% vs 77.8%, P = 0.649; respectively). Multivariate analysis confirmed severe complication was an independent risk factor for decreased OS. Further analysis showed that older age, lower body mass index (BMI), and combined resection were independent risk factor for the occurrence of severe complications. Conclusion: Severe complications adversely affected long-term survival outcomes after LTG with D2 lymph node dissection for AGC. More attention should be paid to patients at high risk for severe complications in preoperative assessment and postoperative management.

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