lyme neuroborreliosis
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2022 ◽  
Vol 4 (1) ◽  
Author(s):  
Deborah K. Erhart ◽  
Vera Bracknies ◽  
Susanne Lutz-Schuhbauer ◽  
Sonja Wigand ◽  
Hayrettin Tumani

AbstractThe diagnosis of chronic lyme neuroborreliosis can be a challenge even for experienced neurologists. The clinical picture may be multifaceted, including polyradiculitis to cranial nerve palsies, meningitis, encephalomyelitis, encephalopathy and peripheral neuropathy. We report on a patient presenting with basal leptomeningoencephalitis associated with vasculopathy where the chemokine CXCL13 in cerebrospinal fluid played an important diagnostic role.


2022 ◽  
pp. 1-2
Author(s):  
João Almeida e Melo ◽  
João Gama Marques

Abstract After reading an article in the journal, regarding affective disorders in patients with rare illnesses, the authors would like to discuss a case of non-affective psychosis, presenting with olfactory reference and Truman symptoms, in a patient with three unusual conditions: Gilbert disease, Hughes syndrome and Lyme neuroborreliosis.


Nursing ◽  
2021 ◽  
Vol 51 (12) ◽  
pp. 60-62
Author(s):  
Danica Stevenson ◽  
Alice Hoang ◽  
Nozomi Schmoock ◽  
Bridget Parsh

Author(s):  
Kimberly Keith ◽  
Kristofer Årestedt ◽  
Ivar Tjernberg

Abstract The purpose of this study was to describe the epidemiology of Lyme neuroborreliosis (LNB) in Kalmar County, in southern Sweden, between 2008 and 2019, and to analyse the relationship between the LNB incidence and climate factors. Data containing cerebrospinal fluid (CSF) cell counts and borrelia CSF/serum antibody index results was received from the departments of clinical chemistry and microbiology at Kalmar County hospital. For this study, we defined LNB as a case with a positive borrelia antibody CSF/serum index and CSF leukocytes > 5 × 106/L. Climate data including mean temperature, humidity and precipitation covering Kalmar County was collected from the Swedish Meteorological and Hydrological Institute. A total of 5051 paired serum-CSF samples from 4835 patients were investigated of which 251 laboratory LNB cases were found. The average annual LNB incidence in Kalmar County 2008–2019 was 8.8 cases per 100,000 inhabitants. Positive relationships were observed between mean temperature and LNB incidence (p < 0.001) as well as precipitation and LNB incidence (p = 0.003), both with a one calendar month delay. The results suggest an association between climate factors such as mean temperature and precipitation and LNB incidence, presumably through increased/decreased human-tick interactions. This calls for increased awareness of LNB in both the short perspective after periods of warmth and heavy precipitation as well as in a longer perspective in relation to possible climate change. Further studies with larger study groups, covering other geographical areas and over longer periods of time are needed to confirm these findings.


Author(s):  
Fredrikke Christie Knudtzen ◽  
Randi Eikeland ◽  
Daniel Bremell ◽  
Else Quist-Paulsen ◽  
Isik Somuncu Johansen ◽  
...  

2021 ◽  
Author(s):  
Christian P. M. Stenør ◽  
Sahla El Mahdaoui ◽  
Nils Wolfram

Author(s):  
Sofie Haglund ◽  
Malin Lager ◽  
Paula Gyllemark ◽  
Gärda Andersson ◽  
Oskar Ekelund ◽  
...  

AbstractThe chemokine CXCL13 is used as complement to serology in the diagnostics of Lyme neuroborreliosis (LNB). We evaluated and compared the semi-quantitative, cassette-based ReaScan CXCL13 assay with the quantitative recomBead CXCL13 assay using a collection of 209 cerebrospinal fluid samples. The categorical agreement between results interpreted as negative, grey zone, and positive by the two methods was 87%. The diagnostic sensitivity was higher using the recomBead assay, whereas specificity was higher using ReaScan. Few manual steps, and a short turn-around time with no batching of samples makes the ReaScan CXCL13 assay an attractive complement to serology in the diagnostics of LNB.


2021 ◽  
Vol 429 ◽  
pp. 118918
Author(s):  
Davide Cardellini ◽  
Maria Rigoni ◽  
Federico Giopato ◽  
Alberto Terrin ◽  
Alessandra Vidali ◽  
...  

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