scholarly journals NADPH oxidase inhibition rescues keratinocytes from elevated oxidative stress in a 2D atopic dermatitis and psoriasis model

2020 ◽  
Vol 29 (8) ◽  
pp. 749-758
Author(s):  
Hila Emmert ◽  
Melina Fonfara ◽  
Elke Rodriguez ◽  
Stephan Weidinger
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Nadph Oxidase ◽  
Oxidase Inhibition ◽  
Nadph Oxidase Inhibition

scholarly journals Apocynin Treatment Prevents Cardiac Connexin 43 Hemichannels Hyperactivity by Reducing Nitroso-Redox Stress in Mdx Mice

2020 ◽  
Vol 21 (15) ◽  
pp. 5415 ◽  
Author(s):  
Alejandra Z. Vielma ◽  
Mauricio P. Boric ◽  
Daniel R. Gonzalez
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
Connexin 43 ◽  
Ventricular Remodeling ◽  
Cardiac Contractility ◽  
Mdx Mice ◽  
Redox Stress ◽  
Systemic Oxidative Stress ◽  
Oxidase Inhibition ◽  
Nadph Oxidase Inhibition

Duchenne muscular dystrophy (DMD) is a fatal disease that causes cardiomyopathy and is associated with oxidative stress. In the heart, oxidative stress interferes with the location of connexin 43 (Cx43) to the intercalated discs causing its lateralization to the plasma membrane where Cx43 forms hemichannels. We tested the hypothesis that in DMD cardiomyopathy, increased oxidative stress is associated with the formation and activation of Cx43 hemichannels. For this, we used mdx mice as a DMD model and evaluated cardiac function, nitroso-redox changes and Cx43 hemichannels permeability. Mdx hearts presented increased NADPH oxidase-derived oxidative stress and increased Cx43 S-nitrosylation compared to controls. These redox changes were associated with increased Cx43 lateralization, decreased cardiac contractility and increased arrhythmic events. Pharmacological inhibition of NADPH oxidase using apocynin (one month) reduced systemic oxidative stress and reversed the aforementioned changes towards normal, except Cx43 lateralization. Opening of Cx43 hemichannels was blocked by apocynin treatment and by acute hemichannel blockade with carbenoxolone. NADPH oxidase inhibition also prevented the occurrence of apoptosis in mdx hearts and reversed the ventricular remodeling. These results show that NADPH oxidase activity in DMD is associated with S-nitrosylation and opening of Cx43 hemichannels. These changes lead to apoptosis and cardiac dysfunction and were prevented by NADPH oxidase inhibition.

scholarly journals NADPH Oxidase Inhibition Attenuates Oxidative Stress but Not Hypertension Produced by Chronic ET-1

Hypertension ◽  
2005 ◽  
Vol 45 (2) ◽  
pp. 283-287 ◽  
Author(s):  
Ahmed A. Elmarakby ◽  
E. Dabbs Loomis ◽  
Jennifer S. Pollock ◽  
David M. Pollock
Keyword(s):  
Oxidative Stress ◽  
Nadph Oxidase ◽  
Oxidase Inhibition ◽  
Nadph Oxidase Inhibition

Towards specific NADPH oxidase inhibition by small synthetic peptides

2012 ◽  
Vol 69 (14) ◽  
pp. 2307-2314 ◽  
Author(s):  
Jamel El-Benna ◽  
Pham My-Chan Dang ◽  
Axel Périanin
Keyword(s):  
Nadph Oxidase ◽  
Synthetic Peptides ◽  
Oxidase Inhibition ◽  
Nadph Oxidase Inhibition

scholarly journals Reducing age-dependent monocyte-derived macrophage activation contributes to the therapeutic efficacy of NADPH oxidase inhibition in spinal cord injury

2019 ◽  
Vol 76 ◽  
pp. 139-150 ◽  
Author(s):  
Bei Zhang ◽  
William M. Bailey ◽  
Anna Leigh McVicar ◽  
Andrew N. Stewart ◽  
Amy K. Veldhorst ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nadph Oxidase ◽  
Therapeutic Efficacy ◽  
Macrophage Activation ◽  
Cord Injury ◽  
Age Dependent ◽  
Oxidase Inhibition ◽  
Nadph Oxidase Inhibition
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