Comparison of the effects of losartan, captopril, angiotensin II type 2 receptor agonist compound 21, and MAS receptor agonist AVE 0991 on myocardial ischemia‐reperfusion necrosis in rats

2021 ◽  
Author(s):  
Zoubir Djerada
Keyword(s):  
Angiotensin Ii ◽  
Myocardial Ischemia ◽  
Receptor Agonist ◽  
Ischemia Reperfusion ◽  
Mas Receptor ◽  
Compound 21 ◽  
Myocardial Ischemia Reperfusion

Effect of angiotensin II type 2 receptor blockade on mitogen activated protein kinases during myocardial ischemia-reperfusion

2004 ◽  
Vol 258 (1/2) ◽  
pp. 211-218 ◽  
Author(s):  
Dinender Kumar ◽  
Vijayan Menon ◽  
William R. Ford ◽  
Alexander S. Clanachan ◽  
Bodh I. Jugdutt
Keyword(s):  
Angiotensin Ii ◽  
Myocardial Ischemia ◽  
Protein Kinases ◽  
Ischemia Reperfusion ◽  
Receptor Blockade ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Myocardial Ischemia Reperfusion

scholarly journals Angiotensin II type 2 receptor agonist Compound 21 attenuates pulmonary inflammation in a model of acute lung injury

2018 ◽  
Vol Volume 11 ◽  
pp. 169-178 ◽  
Author(s):  
Mario Menk ◽  
Jan Adriaan Graw ◽  
Clarissa von Haefen ◽  
Henrik Kurt Alexander Steinkraus ◽  
Burkhard Lachmann ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Angiotensin Ii ◽  
Lung Injury ◽  
Receptor Agonist ◽  
Pulmonary Inflammation ◽  
Compound 21

Protective effects of the angiotensin II AT2 receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach

2018 ◽  
Vol 132 (5) ◽  
pp. 581-593 ◽  
Author(s):  
Douglas M. Bennion ◽  
Chad H. Jones ◽  
Alex N. Dang ◽  
Jacob Isenberg ◽  
Justin T. Graham ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Angiotensin Ii ◽  
Receptor Agonist ◽  
At2 Receptor ◽  
Protective Effects ◽  
Neuroprotective Effects ◽  
Receptor Agonists ◽  
Compound 21 ◽  
Neuroprotective Actions

Significant neuroprotective effects of angiotensin II type 2 (AT2) receptor (AT2 receptor) agonists in ischemic stroke have been previously demonstrated in multiple studies. However, the routes of agonist application used in these pre-clinical studies, direct intracerebroventricular (ICV) and systemic administration, are unsuitable for translation into humans; in the latter case because AT2 receptor agonists are blood–brain barrier (BBB) impermeable. To circumvent this problem, in the current study we utilized the nose-to-brain (N2B) route of administration to bypass the BBB and deliver the selective AT2 receptor agonist Compound 21 (C21) to naïve rats or rats that had undergone endothelin 1 (ET-1)-induced ischemic stroke. The results obtained from the present study indicated that C21 applied N2B entered the cerebral cortex and striatum within 30 min in amounts that are therapeutically relevant (8.4–9 nM), regardless of whether BBB was intact or disintegrated. C21 was first applied N2B at 1.5 h after stroke indeed provided neuroprotection, as evidenced by a highly significant, 57% reduction in cerebral infarct size and significant improvements in Bederson and Garcia neurological scores. N2B-administered C21 did not affect blood pressure or heart rate. Thus, these data provide proof-of-principle for the idea that N2B application of an AT2 receptor agonist can exert neuroprotective actions when administered following ischemic stroke. Since N2B delivery of other agents has been shown to be effective in certain human central nervous system diseases, the N2B application of AT2 receptor agonists may become a viable mode of delivering these neuroprotective agents for human ischemic stroke patients.

scholarly journals Impact of hyperglycemia on myocardial ischemia–reperfusion susceptibility and ischemic preconditioning in hearts from rats with type 2 diabetes

2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Steen Buus Kristiansen ◽  
Kim Bolther Pælestik ◽  
Jacob Johnsen ◽  
Nichlas Riise Jespersen ◽  
Kasper Pryds ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Myocardial Ischemia ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion ◽  
Myocardial Ischemia Reperfusion

scholarly journals Protection against Myocardial Ischemia-Reperfusion Injury at Onset of Type 2 Diabetes in Zucker Diabetic Fatty Rats Is Associated with Altered Glucose Oxidation

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64093 ◽  
Author(s):  
Jonas Agerlund Povlsen ◽  
Bo Løfgren ◽  
Christian Dalgas ◽  
Rune Isak Dupont Birkler ◽  
Mogens Johannsen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Myocardial Ischemia ◽  
Glucose Oxidation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Altered Glucose ◽  
Zucker Diabetic Fatty Rats ◽  
Myocardial Ischemia Reperfusion Injury ◽  
Myocardial Ischemia Reperfusion
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