A surprising observation that oxygen can affect the product enantiopurity of an enzyme-catalysed reaction

FEBS Journal ◽  
2012 ◽  
Vol 279 (22) ◽  
pp. 4160-4171 ◽  
Author(s):  
Anna Fryszkowska ◽  
Helen S. Toogood ◽  
David Mansell ◽  
Gill Stephens ◽  
John M. Gardiner ◽  
...  
Keyword(s):  
Catalysed Reaction ◽  
Surprising Observation

scholarly journals Endemic Behaviour of SIS Epidemics with General Infectious Period Distributions

2014 ◽  
Vol 46 (01) ◽  
pp. 241-255 ◽  
Author(s):  
Peter Neal
Keyword(s):  
Epidemic Model ◽  
Branching Process ◽  
Endemic Equilibrium ◽  
Infectious Period ◽  
Sis Epidemic Model ◽  
Branching Process With Immigration ◽  
Sis Epidemic ◽  
Sis Epidemics ◽  
Surprising Observation

We study the endemic behaviour of a homogeneously mixing SIS epidemic in a population of size N with a general infectious period, Q, by introducing a novel subcritical branching process with immigration approximation. This provides a simple but useful approximation of the quasistationary distribution of the SIS epidemic for finite N and the asymptotic Gaussian limit for the endemic equilibrium as N → ∞. A surprising observation is that the quasistationary distribution of the SIS epidemic model depends on Q only through

Gold-catalysed cyclisation of N-propargylic β-enaminones to form 3-methylene-1-pyrroline derivatives

2014 ◽  
Vol 12 (18) ◽  
pp. 2869-2873 ◽  
Author(s):  
Kommuru Goutham ◽  
N. S. V. M. Rao Mangina ◽  
Surisetti Suresh ◽  
Pallepogu Raghavaiah ◽  
Galla V. Karunakar
Keyword(s):  
Catalysed Reaction

A gold(i) catalysed reaction between N-propargylic β-enaminones and arynes was developed to access 3-methylene-1-pyrrolines. The title compounds were obtained in 57–78% yields.

scholarly journals Synthesis of Water-Soluble 7-O-Carboxymethyl-Genistein

2017 ◽  
Vol 41 (3) ◽  
pp. 183-185
Author(s):  
Zhiling Cao ◽  
Qiao Wu ◽  
Jing Cheng ◽  
Dandan Zhu ◽  
Wengqi Teng ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Sodium Salt ◽  
Water Solubility ◽  
Clinical Chemistry ◽  
Water Soluble ◽  
Aqueous Acetic Acid ◽  
Carboxylate Group ◽  
Target Compound ◽  
Catalysed Reaction

A three-step synthesis from genistein of the water-soluble sodium salt of 7-O-carboxymethyl-genistein is described. Base-catalysed reaction of genistein with t-butyl bromoacetate gave 7-O-(carbo-t-butoxy)methyl-genistein, which was hydrolysed by aqueous acetic acid to 7-O-carboxymethyl-genistein and neutralised (NaHCO3) to give the target compound. The carboxylate group enhanced the water-solubility of genistein more than a thousand-fold and the new derivate will be useful as a candidate compound in pharmacological and clinical chemistry studies of isoflavones.

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