An update on cognitive frailty: Its definition, impact, associated factors and underlying mechanisms, and interventions

AbstractFuzhenghuayu (FZHY) is a compound extracted from natural plants. Its anti-fibrotic effect has been confirmed in experimental and clinical studies. However, precise effects and underlying mechanisms of FZHY in liver angiogenesis largely remain understood. In this study, we investigated the effects of FZHY on sinusoidal capillarization and angiogenesis with mice challenged for Carbon tetrachloride (CCl4) and dimethylnitrosamine (DMN), in vitro human hepatic sinusoidal endothelial cells (HHSEC) and Human Umbilical Vein Endothelial Cell (HUVEC) 3D fibrin gel model. Besides its anti-fibrotic effect, FZHY ameliorated CCl4 and DMN-induced sinusoidal capillarization, angiogenesis and expression of angiogenesis-associated factors, i.e. CD31, VEGF, VEGF receptor II, phosphor-ERK and HIF-1α. Consistent with the findings based on animal models, inhibitory effects of FZHY on capillarization and angiogenesis were further confirmed in HHSEC and the HUVEC 3D fibrin gel model, respectively. These data suggest that FZHY ameliorates not only liver fibrosis but also vessel remodeling in experimental models. Therefore, FZHY might be a potentially useful drug to treat liver cirrhosis in clinical practice.

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A systematic review and meta-analysis on cognitive frailty in community-dwelling older adults: risk and associated factors

Aging & Mental Health ◽

10.1080/13607863.2021.1884844 ◽

2021 ◽

pp. 1-13 ◽

Cited By ~ 1

Author(s):

Izabela Pereira Vatanabe ◽

Renata Valle Pedroso ◽

Ramon Handerson Gomes Teles ◽

Julio Cesar Ribeiro ◽

Patricia Regina Manzine ◽

...

Keyword(s):

Systematic Review ◽

Older Adults ◽

Associated Factors ◽

Meta Analysis ◽

Community Dwelling ◽

Cognitive Frailty ◽

Community Dwelling Older Adults

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The limits of human performance

Essays in Biochemistry ◽

10.1042/bse0440011 ◽

2008 ◽

Vol 44 ◽

pp. 11-26 ◽

Cited By ~ 14

Author(s):

Ralph Beneke ◽

Dieter Böning

Keyword(s):

Human Performance ◽

Safety Margin ◽

Afferent Input ◽

Metabolic Energy ◽

Human Organism ◽

Mechanical Resistance ◽

As Doping ◽

Gene And Protein Expression ◽

Underlying Mechanisms ◽

Biochemical Research

Human performance, defined by mechanical resistance and distance per time, includes human, task and environmental factors, all interrelated. It requires metabolic energy provided by anaerobic and aerobic metabolic energy sources. These sources have specific limitations in the capacity and rate to provide re-phosphorylation energy, which determines individual ratios of aerobic and anaerobic metabolic power and their sustainability. In healthy athletes, limits to provide and utilize metabolic energy are multifactorial, carefully matched and include a safety margin imposed in order to protect the integrity of the human organism under maximal effort. Perception of afferent input associated with effort leads to conscious or unconscious decisions to modulate or terminate performance; however, the underlying mechanisms of cerebral control are not fully understood. The idea to move borders of performance with the help of biochemicals is two millennia old. Biochemical findings resulted in highly effective substances widely used to increase performance in daily life, during preparation for sport events and during competition, but many of them must be considered as doping and therefore illegal. Supplements and food have ergogenic potential; however, numerous concepts are controversially discussed with respect to legality and particularly evidence in terms of usefulness and risks. The effect of evidence-based nutritional strategies on adaptations in terms of gene and protein expression that occur in skeletal muscle during and after exercise training sessions is widely unknown. Biochemical research is essential for better understanding of the basic mechanisms causing fatigue and the regulation of the dynamic adaptation to physical and mental training.

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Orienting and Focusing in Voluntary and Involuntary Visuospatial Attention Conditions

Journal of Psychophysiology ◽

10.1027/0269-8803/a000010 ◽

2010 ◽

Vol 24 (3) ◽

pp. 198-209 ◽

Cited By ~ 8

Author(s):

Yan Wang ◽

Jianhui Wu ◽

Shimin Fu ◽

Yuejia Luo

Keyword(s):

Gain Control ◽

Event Related Potentials ◽

Stimulus Onset ◽

Orientation Discrimination ◽

Involuntary Attention ◽

Attention Condition ◽

Voluntary Attention ◽

Visual Spatial ◽

Related Potentials ◽

Underlying Mechanisms

In the present study, we used event-related potentials (ERPs) and behavioral measurements in a peripherally cued line-orientation discrimination task to investigate the underlying mechanisms of orienting and focusing in voluntary and involuntary attention conditions. Informative peripheral cue (75% valid) with long stimulus onset asynchrony (SOA) was used in the voluntary attention condition; uninformative peripheral cue (50% valid) with short SOA was used in the involuntary attention condition. Both orienting and focusing were affected by attention type. Results for attention orienting in the voluntary attention condition confirmed the “sensory gain control theory,” as attention enhanced the amplitude of the early ERP components, P1 and N1, without latency changes. In the involuntary attention condition, compared with invalid trials, targets in the valid trials elicited larger and later contralateral P1 components, and smaller and later contralateral N1 components. Furthermore, but only in the voluntary attention condition, targets in the valid trials elicited larger N2 and P3 components than in the invalid trials. Attention focusing in the involuntary attention condition resulted in larger P1 components elicited by targets in small-cue trials compared to large-cue trials, whereas in the voluntary attention condition, larger P1 components were elicited by targets in large-cue trials than in small-cue trials. There was no interaction between orienting and focusing. These results suggest that orienting and focusing of visual-spatial attention are deployed independently regardless of attention type. In addition, the present results provide evidence of dissociation between voluntary and involuntary attention during the same task.

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Response Interference as a Mechanism Underlying Implicit Measures

European Journal of Psychological Assessment ◽

10.1027/1015-5759.24.4.218 ◽

2008 ◽

Vol 24 (4) ◽

pp. 218-225 ◽

Cited By ~ 28

Author(s):

Bertram Gawronski ◽

Roland Deutsch ◽

Etienne P. LeBel ◽

Kurt R. Peters

Keyword(s):

Task Performance ◽

Psychological Research ◽

Implicit Measures ◽

Mediation Model ◽

Response Interference ◽

Relevant Evidence ◽

Moderated Mediation Model ◽

Stimulus Features ◽

Underlying Mechanisms

Over the last decade, implicit measures of mental associations (e.g., Implicit Association Test, sequential priming) have become increasingly popular in many areas of psychological research. Even though successful applications provide preliminary support for the validity of these measures, their underlying mechanisms are still controversial. The present article addresses the role of a particular mechanism that is hypothesized to mediate the influence of activated associations on task performance in many implicit measures: response interference (RI). Based on a review of relevant evidence, we argue that RI effects in implicit measures depend on participants attention to association-relevant stimulus features, which in turn can influence the reliability and the construct validity of these measures. Drawing on a moderated-mediation model (MMM) of task performance in RI paradigms, we provide several suggestions on how to address these problems in research using implicit measures.

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The More You Say, the Less They Hear

Journal of Media Psychology Theories Methods and Applications ◽

10.1027/1864-1105/a000135 ◽

2015 ◽

Vol 27 (4) ◽

pp. 159-169 ◽

Cited By ~ 3

Author(s):

Elsbeth D. Asbeek Brusse ◽

Marieke L. Fransen ◽

Edith G. Smit

Keyword(s):

Hearing Protection ◽

Entertainment Education ◽

Mediating Role ◽

Attitude Measures ◽

Underlying Mechanisms

Abstract. This study examined the effects of disclosure messages in entertainment-education (E-E) on attitudes toward hearing protection and attitude toward the source. In addition, the (mediating) role of the underlying mechanisms (i.e., transportation, identification, and counterarguing) was studied. In an experiment (N = 336), three different disclosure messages were compared with a no-disclosure condition. The results show that more explicit disclosure messages negatively affect transportation and identification and stimulate the generation of counterarguments. In addition, the more explicit disclosure messages affect both attitude measures via two of these processes (i.e., transportation and counterarguing). Less explicit disclosure messages do not have this effect. Implications of the findings are discussed.

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