Continuous infusion of extended half-life factor VIII (efmoroctocog alpha) for surgery in severe haemophilia A

Haemophilia ◽  
2018 ◽  
Vol 24 (4) ◽  
pp. e280-e283
Author(s):  
I. C. L. Kremer Hovinga ◽  
R. E. G. Schutgens ◽  
P. R. van der Valk ◽  
L. F. D. van Vulpen ◽  
E. P. Mauser-Bunschoten ◽  
...  
Keyword(s):  
Factor Viii ◽  
Continuous Infusion ◽  
Half Life ◽  
Haemophilia A ◽  
Severe Haemophilia ◽  
Life Factor

scholarly journals Safety and efficacy of BAY 94–9027, an extended‐half‐life factor VIII, during minor surgical procedures in patients with severe haemophilia A

Haemophilia ◽  
2021 ◽  
Author(s):  
Elena Santagostino ◽  
Shadan Lalezari ◽  
Mark T. Reding ◽  
Jonathan Ducore ◽  
Heng Joo Ng ◽  
...  
Keyword(s):  
Factor Viii ◽  
Surgical Procedures ◽  
Half Life ◽  
Haemophilia A ◽  
Severe Haemophilia ◽  
Safety And Efficacy ◽  
Minor Surgical Procedures ◽  
Life Factor

Limited sampling strategies for accurate determination of extended half‐life factor VIII pharmacokinetics in severe haemophilia A patients

Haemophilia ◽  
2021 ◽  
Author(s):  
Alanna McEneny‐King ◽  
Pierre Chelle ◽  
Margaret H. Goggans ◽  
Patricia J. Barker ◽  
Timothy W. Jacobs ◽  
...  
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
Accurate Determination ◽  
Haemophilia A ◽  
Severe Haemophilia ◽  
Sampling Strategies ◽  
Limited Sampling ◽  
Life Factor

Continuous infusion of recombinant porcine factor VIII for neurosurgical management of intracranial haemorrhage in a patient with severe haemophilia A with factor VIII inhibitor

Haemophilia ◽  
2020 ◽  
Vol 26 (3) ◽  
Author(s):  
Gordon J. Ruan ◽  
Jimmy J. Mao ◽  
Terin T. Sytsma ◽  
Ivy I. Akogyeram ◽  
Yucai Wang ◽  
...  
Keyword(s):  
Factor Viii ◽  
Continuous Infusion ◽  
Intracranial Haemorrhage ◽  
Factor Viii Inhibitor ◽  
Haemophilia A ◽  
Severe Haemophilia ◽  
Viii Inhibitor

Continuous infusion of recombinant factor VIII formulated with sucrose in surgery: Non-interventional, observational study in patients with severe haemophilia A

Haemophilia ◽  
2014 ◽  
Vol 21 (1) ◽  
pp. e19-e25 ◽  
Author(s):  
K. Meijer ◽  
S. Rauchensteiner ◽  
E. Santagostino ◽  
H. Platokouki ◽  
R. E. G. Schutgens ◽  
...  
Keyword(s):  
Observational Study ◽  
Factor Viii ◽  
Continuous Infusion ◽  
Recombinant Factor Viii ◽  
Haemophilia A ◽  
Severe Haemophilia

scholarly journals Case report: successful perioperative management of patients with haemophilia A using an extended half-life factor VIII (Efmoroctocog alfa) during neurosurgical procedures

2021 ◽  
Vol 12 ◽  
pp. 204062072199368
Author(s):  
Florian Kocher ◽  
Andreas Seeber ◽  
Johannes Kerschbaumer ◽  
Stefan Schmidt ◽  
Dominik Wolf ◽  
...  
Keyword(s):  
High Risk ◽  
Factor Viii ◽  
Half Life ◽  
Perioperative Management ◽  
Fatal Outcome ◽  
Bleeding Complications ◽  
Neurosurgical Procedures ◽  
Haemophilia A ◽  
Surgical Interventions ◽  
Life Factor

Patients with haemophilia A (HA) undergoing neurosurgical procedures have a high risk of haemorrhage with potential fatal outcome. Here, we present a successful perioperative haemostatic concept applying an extended half-life factor VIII (EHL FVIII), Efmoroctocog alfa, in two patients with HA undergoing neurosurgery for paramedian right-sided disc herniation (case 1) and astrocytoma (case 2). After adequate EHL FVIII treatment the surgical procedures were performed without any bleeding complications despite the high-risk interventions. Laboratory measurements confirmed stable FVIII levels throughout the hospital stay. We suggest close interdisciplinary collaboration between involved clinicians as mandatory prerequisite for an optimized perioperative management in patients with HA. The presented cases indicate, that the increased stability, safety and fewer injections provide a rationale to use EHL FVIII products in HA patients undergoing surgical interventions with a very high bleeding risk.

scholarly journals Extended half-life pegylated, full-length recombinant factor VIII for prophylaxis in children with severe haemophilia A

Haemophilia ◽  
2016 ◽  
Vol 23 (2) ◽  
pp. 238-246 ◽  
Author(s):  
E. S. Mullins ◽  
O. Stasyshyn ◽  
M. T. Alvarez-Román ◽  
D. Osman ◽  
R. Liesner ◽  
...  
Keyword(s):  
Factor Viii ◽  
Half Life ◽  
Full Length ◽  
Recombinant Factor Viii ◽  
Haemophilia A ◽  
Severe Haemophilia

Continuous infusion of factor VIII concentrates in obese patients with severe haemophilia A: is weight-based dose-adjustment required?

Haemophilia ◽  
2015 ◽  
Vol 22 (1) ◽  
pp. e62-e64 ◽  
Author(s):  
A. Boban ◽  
S. Henrard ◽  
C. Lambert ◽  
C. Hermans
Keyword(s):  
Factor Viii ◽  
Continuous Infusion ◽  
Dose Adjustment ◽  
Haemophilia A ◽  
Obese Patients ◽  
Severe Haemophilia ◽  
Factor Viii Concentrates
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