Cognitive performance in patients with episodic cluster headache outside and inside the active cluster

2021 ◽  
Vol 61 (1) ◽  
pp. 209-215
Author(s):  
María Pilar Navarro‐Pérez ◽  
Elena Bellosta‐Diago ◽  
Alejandro Viloria‐Alebesque ◽  
Alberto Garrido‐Fernández ◽  
Alba López‐Bravo ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Cognitive Performance ◽  
Episodic Cluster Headache ◽  
Active Cluster

Abnormal 5-HT1D Receptor Function in Cluster Headache: A Neuroendocrine Study with Sumatriptan

Cephalalgia ◽  
2003 ◽  
Vol 23 (5) ◽  
pp. 354-360 ◽  
Author(s):  
L Pinessi ◽  
I Rainero ◽  
W Valfrè ◽  
R Lo Giudice ◽  
M Ferrero ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Cluster Headache ◽  
Adrenocorticotropic Hormone ◽  
Active Phase ◽  
Receptor Function ◽  
Remission Period ◽  
Episodic Cluster Headache ◽  
Subcutaneous Sumatriptan ◽  
Active Cluster

The purpose of this study was to assess the sensitivity of 5-HT1D receptors in patients with episodic cluster headache using sumatriptan as a pharmacological probe. The drug, a selective 5-HT1B/1D agonist, stimulates the secretion of growth hormone and inhibits the release of prolactin, adrenocorticotropic hormone (ACTH) and cortisol. These effects may be used to explore the function of serotonergic systems in vivo. We administered subcutaneous sumatriptan and placebo to 20 patients with cluster headache (10 in the active phase and 10 in the remission period) and to 12 controls. The sumatriptan-induced increase of growth hormone concentrations was significantly ( P < 0.05) blunted in patients with active cluster headache. Prolactin and ACTH responses to the drug were significantly ( P < 0.05) reduced in patients with cluster headache, both in the active and in the remission period. Our results suggest that cerebral serotonergic functions mediated by 5-HT1D receptors are altered in patients with episodic cluster headache.

Cognitive Performance in Episodic Cluster Headache

Pain Medicine ◽  
2018 ◽  
Vol 20 (5) ◽  
pp. 1032-1037 ◽  
Author(s):  
Sonia Santos-Lasaosa ◽  
Elena Bellosta-Diago ◽  
Alba López-Bravo ◽  
Alejandro Viloria-Alebesque ◽  
Alberto Garrido-Fernández ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Cognitive Performance ◽  
Episodic Cluster Headache

Efficacy of galcanezumab in patients with episodic cluster headaches and a history of preventive treatment failure

2021 ◽  
Vol 4 ◽  
pp. 251581632110156
Author(s):  
Brian Plato ◽  
J Scott Andrews ◽  
Mallikarjuna Rettiganti ◽  
Antje Tockhorn-Heidenreich ◽  
Jennifer Bardos ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Treatment Failure ◽  
Preventive Treatment ◽  
Mean Difference ◽  
Least Square ◽  
Double Blind Study ◽  
Double Blind ◽  
Cluster Headache Attack ◽  
Episodic Cluster Headache ◽  
History Of

Objective: The efficacy of galcanezumab was evaluated in patients with episodic cluster headache and history of preventive treatment failure. Methods: In the randomized, 8-week, double-blind study (CGAL), patients with episodic cluster headache received once-monthly subcutaneous injections of galcanezumab 300 mg or placebo. Patients who completed CGAL and enrolled in an open-label study were queried for preventive treatment history. In a subset of patients with a known history of failure of verapamil or any other prior preventive treatment, a post hoc analysis of least square mean change from baseline in weekly cluster headache attack frequency across Weeks 1 to 3 was assessed. Results: Fifteen patients provided data for known history of prior preventive treatment failure (6 placebo, 9 galcanezumab), of whom 11 failed verapamil. The mean reduction in the weekly frequency of cluster headache attacks was greater with galcanezumab compared to placebo among patients with prior preventive treatment failure (8.2 versus 2.4); mean difference 5.8 (95% confidence interval [CI] 2.0, 13.6) and among patients with verapamil failure (10.1 versus 1.6); mean difference 8.5 (95% CI 0.4, 16.7). Conclusion: In this exploratory analysis of patients with a known history of prior preventive treatment failures, treatment with galcanezumab resulted in greater mean reductions in weekly cluster headache attacks compared with placebo. ClinicalTrials.gov: NCT02397473 (I5Q-MC-CGAL) NCT02797951 (I5Q-MC-CGAR)

scholarly journals Efficacy of transdermal rotigotine in chronic cluster headache: A case series

2018 ◽  
Vol 1 ◽  
pp. 251581631880969
Author(s):  
Cherubino Di Lorenzo ◽  
Lanfranco Pellesi ◽  
Gianluca Coppola ◽  
Vincenzo Parisi ◽  
Maurizio Evangelista ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Case Series ◽  
Chronic Cluster Headache ◽  
Drug Resistant ◽  
Transdermal Patch ◽  
Full Resolution ◽  
Episodic Cluster Headache ◽  
Monoaminergic System ◽  
Rotigotine Transdermal Patch ◽  
Effective Treatments

Cluster headache (CH) is one of the most severe forms of headache, but the number of effective treatments is still limited. Recently, we reported the case of a drug-resistant CH patient responsive to the rotigotine transdermal patch, which is used in the treatment of Parkinson’s disease. This report formed the basis for a case series where other drug-resistant CH patients were treated with rotigotine. Here are the results of this study. Twenty-two CH patients underwent the treatment. Eight were episodic cluster headache (ECH) patients and 14 were chronic cluster headache (CCH) patients. Of the eight ECH patients, four reported that their CH had been stopped by the treatment. Of the 14 CCH patients, 11 were considered responders to the treatment (5 experienced a full resolution of headache, and 6 had a headache reduction of at least 50% in terms of mean monthly number of attacks). Our case series confirms the previous observation that rotigotine could be helpful in the treatment of CH. It may even influence the monoaminergic system that has a key role in the pathogenesis of CH.

scholarly journals Use of High Sumatriptan Dosages During Episodic Cluster Headache: Three Clinical Cases

1996 ◽  
Vol 36 (6) ◽  
pp. 389-391 ◽  
Author(s):  
V. Centonze ◽  
B.M. Polito ◽  
E. Attolini ◽  
M.A. Cassiano ◽  
C. Sabba ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Episodic Cluster Headache ◽  
Clinical Cases

Unilateral Impairment of Pupillary Responsiveness to Noxious Stimulation of Sural Nerve in Episodic Cluster Headache

1985 ◽  
pp. 283-289 ◽  
Author(s):  
G. Sandrini ◽  
G. Micieli ◽  
E. Martignoni ◽  
G. Bono ◽  
F. Savoldi ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Sural Nerve ◽  
Noxious Stimulation ◽  
Episodic Cluster Headache ◽  
Stimulation Of

Lack of β-Endorphin and β-Lipotropin Circadian Rhythmicity in Episodic Cluster Headache: A Model for Chronopathology

1985 ◽  
pp. 269-275 ◽  
Author(s):  
G. Nappi ◽  
F. Facchinetti ◽  
G. Bono ◽  
F. Petraglia ◽  
G. Micieli ◽  
...  
Keyword(s):  
Cluster Headache ◽  
Circadian Rhythmicity ◽  
Episodic Cluster Headache
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