Neutrophil gelatinase-associated lipocalin accurately predicts renal tubular injury in patients with chronic hepatitis B treated with nucleos(t)ide analogs

2017 ◽  
Vol 48 (2) ◽  
pp. 144-152
Author(s):  
Yao Zhang ◽  
Jing Li ◽  
Fahong Li ◽  
Xun Qi ◽  
Jiming Zhang
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Tubular Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Renal Tubular ◽  
Neutrophil Gelatinase

scholarly journals Reversal of Proximal Renal Tubular Dysfunction after Nucleotide Analogue Withdrawal in Chronic Hepatitis B

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Abhasnee Sobhonslidsuk ◽  
Pawin Numthavaj ◽  
Jirachaya Wanichanuwat ◽  
Areepan Sophonsritsuk ◽  
Supanna Petraksa ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Fractional Excretion ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Nucleotide Analogue ◽  
Proximal Renal Tubular Dysfunction ◽  
Renal Tubular ◽  
One Year

Aims. Proximal renal tubular dysfunction (PRTD) is an infrequent complication after nucleotide analogue therapy. We evaluated the outcomes of PRTD and nephrotoxicity after nucleotide analogue withdrawal in chronic hepatitis B (CHB). Methods. A longitudinal follow-up study was performed in patients with PRTD after nucleotide analogue discontinuation. Serum and urine were collected at baseline and every 3 months for one year. The fractional excretion of phosphate (PO4), uric acid (UA), and potassium and tubular maximal reabsorption rate of PO4 to glomerular filtration rate (TmPO4/GFR) were calculated. Renal losses were defined based on the criteria of substance losses. Subclinical PRTD and overt PRTD were diagnosed when 2 and ≥3 criteria were identified. Results. Eight subclinical and eight overt PRTD patients were enrolled. After nucleotide analogue withdrawal, there were overall improvements in GFR, serum PO4, and UA. Renal loss of PO4, UA, protein, and β2-microglobulin reduced over time. At one year, complete reversal of PRTD was seen in 13 patients (81.2%). Improvements in PRTD were seen in all but one patient. Conclusion. One year after nucleotide analogue withdrawal, PRTD was resolved in most patients. Changes in TmPO4/GFR, urinary protein, and β2-microglobulin indicate that urinary biomarkers may represent an early sign of PRTD recovery.

Altered Underlying Renal Tubular Function in Patients With Chronic Hepatitis B Receiving Nucleos(t)ide Analogs in a Real-World Setting

2016 ◽  
Vol 50 (9) ◽  
pp. 779-789 ◽  
Author(s):  
Sonia Rodríguez-Nóvoa ◽  
Javier García-Samaniego ◽  
Martín Prieto ◽  
José L. Calleja ◽  
Juan M. Pascasio ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Real World ◽  
Tubular Function ◽  
Renal Tubular Function ◽  
Real World Setting ◽  
Renal Tubular

731 Nucleotide Analogue-Related Fanconi Syndrome and Severe Proximal Renal Tubular Dysfunction During the Treatment of Chronic Hepatitis B

2015 ◽  
Vol 148 (4) ◽  
pp. S-993
Author(s):  
Abhasnee Sobhonslidsuk ◽  
Jirachaya Wanichanuwat ◽  
Bunyong Phakdeekitcharoen ◽  
Areepan Sophonsritsuk ◽  
Supanna Petraksa ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Fanconi Syndrome ◽  
Tubular Dysfunction ◽  
Renal Tubular Dysfunction ◽  
Nucleotide Analogue ◽  
Proximal Renal Tubular Dysfunction ◽  
Renal Tubular

Evaluation of renal injury in children with uncorrected CHDs with significant shunt using urinary neutrophil gelatinase-associated lipocalin

2020 ◽  
Vol 30 (9) ◽  
pp. 1313-1320
Author(s):  
Promise Monday ◽  
Nosakhare J. Idouriyekemwen ◽  
Wilson E. Sadoh
Keyword(s):  
Renal Injury ◽  
Tertiary Hospital ◽  
Renal Ultrasound ◽  
Healthy Children ◽  
Ultrasound Scan ◽  
Tubular Injury ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Cardiology Clinic ◽  
Renal Tubular ◽  
Neutrophil Gelatinase

AbstractBackground:CHDs can be complicated by renal injury which worsens morbidity and mortality. Urinary neutrophil gelatinase-associated lipocalin, a sensitive and specific biomarker of renal tubular injury, has not been studied in children with uncorrected CHDs. This study evaluated renal injury in children with uncorrected CHDs using this biomarker.Methods:The patients were children with uncorrected CHDs with significant shunt confirmed on echocardiogram with normal renal ultrasound scan, in the paediatric cardiology clinic of a tertiary hospital. The controls were age-matched healthy children recruited from general practice clinics. Information on bio-data and socio-demographics were collected and urine was obtained for measurement of urinary neutrophil gelatinase-associated lipocalin levels.Results:A total of 65 children with uncorrected CHDs aged 2 to 204 months were recruited. Thirty-one (47.7%) were males while 36 (55.4%) had acyanotic CHDs. The median urinary neutrophil gelatinase-associated lipocalin level of patients of 26.10 ng/ml was significantly higher than controls of 16.90 ng/ml (U = 1624.50, p = 0.023). The median urinary neutrophil gelatinase-associated lipocalin level of patients with cyanotic and acyanotic CHDs were 30.2 ng/ml and 22.60 ng/ml respectively; (Mann–Whitney U = 368.50, p = 0.116). The prevalence of renal injury using 95th percentile cut-off value of urinary neutrophil gelatinase-associated lipocalin was 16.9%. Median age of patients with renalinjury was 16 (4–44) months.Conclusions:Children with uncorrected CHDs have renal injury detected as early as infancy. The use of urinary neutrophil gelatinase-associated lipocalin in early detection of renal injury in these children may enhance early intervention and resultant prevention of morbidity and reduction in mortality.

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