Multicenter study on the consciousness‐regaining effect of a newly developed artificial liver support system in acute liver failure: An on‐line continuous hemodiafiltration system

2020 ◽  
Author(s):  
Yasuhiro Takikawa ◽  
Keisuke Kakisaka ◽  
Yuji Suzuki ◽  
Akio Ido ◽  
Tsuyoshi Shimamura ◽  
...  
Keyword(s):  
Liver Failure ◽  
Support System ◽  
Multicenter Study ◽  
Artificial Liver ◽  
Continuous Hemodiafiltration ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System ◽  
On Line

scholarly journals Efficacy of a Larger Version of the Hybrid Artificial Liver Support System Using a Polyurethane Foam/Spheroid Packed-Bed Module in a Warm Ischemic Liver Failure Pig Model for Preclinical Experiments

2003 ◽  
Vol 12 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Yo-Ichi Yamashita ◽  
Mitsuo Shimada ◽  
Eiji Tsujita ◽  
Ken Shirabe ◽  
Hiroyuki Ijima ◽  
...  
Keyword(s):  
Liver Failure ◽  
Polyurethane Foam ◽  
Support System ◽  
Packed Bed ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System ◽  
Group Serum

We have reported the usefulness of a polyurethane foam packed-bed culture system of hepatocyte spheroids as a hybrid artificial liver support system (PUF-HALSS). The aim of this study was to evaluate in detail the efficacy in serum parameters regarding the liver function of a larger version of the PUF-HALSS containing 2 × 1010 porcine hepatocytes for clinical use in warm ischemic liver failure pigs. Warm ischemic liver failure pigs weighing 25 kg were divided into two groups: (1) a control group (n = 3), in which each pig was attached to a PUF-HALSS without hepatocytes, and (2) a HALSS group (n = 3), in which each pig was attached to a PUF-HALSS. In the HALSS group, the increase of blood ammonia was completely suppressed and blood lactate levels were significantly suppressed. The Fisher's ratio was better maintained, and the increase of total bile acid, glycochenodeoxycholic acid, and taurochenodeoxycholic acid was significantly suppressed in the HALSS group. Serum creatinine levels were significantly lower, and blood glucose levels were significantly higher in the HALSS group. Serum levels of tumor necrosis factor- a were not elevated in either group. In conclusion, the larger version of the PUF-HALSS demonstrated many advantages as a liver support system in warm ischemic liver failure pigs.

scholarly journals Survival Benefits With Artificial Liver Support System for Acute-on-Chronic Liver Failure

Medicine ◽  
2016 ◽  
Vol 95 (3) ◽  
pp. e2506 ◽  
Author(s):  
Yi Shen ◽  
Xu-Lin Wang ◽  
Bin Wang ◽  
Jian-Guo Shao ◽  
Yan-Mei Liu ◽  
...  
Keyword(s):  
Liver Failure ◽  
Support System ◽  
Chronic Liver ◽  
Artificial Liver ◽  
Chronic Liver Failure ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System

scholarly journals Artificial liver support system in treatment of liver failure after acute poisoning

2011 ◽  
Vol 2 (4) ◽  
pp. 283 ◽  
Author(s):  
Li-gang Chen ◽  
Bayasi Guleng ◽  
Jian-lin Ren ◽  
Jian-min Chen ◽  
Lin Wang
Keyword(s):  
Liver Failure ◽  
Support System ◽  
Acute Poisoning ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System

Systematic review: extracorporeal bio-artificial liver-support system for liver failure

2012 ◽  
Vol 6 (4) ◽  
pp. 670-683 ◽  
Author(s):  
Jinyang Gu ◽  
Xiaolei Shi ◽  
Haozhen Ren ◽  
Qingxiang Xu ◽  
Jun Wang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Liver Failure ◽  
Support System ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System

Development of liposome as a novel adsorbent for artificial liver support system in liver failure

2019 ◽  
Vol 30 (3) ◽  
pp. 246-254 ◽  
Author(s):  
Yue Shen ◽  
Yifeng Wang ◽  
Yuanyuan Shi ◽  
Huajun Tian ◽  
Qiuyu Zhu ◽  
...  
Keyword(s):  
Liver Failure ◽  
Support System ◽  
Artificial Liver ◽  
Liver Support ◽  
Artificial Liver Support ◽  
Liver Support System ◽  
Artificial Liver Support System
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