Cytokeratin expression in plasmablastic lymphoma – a possible diagnostic pitfall in the routine work‐up of tumours

2020 ◽  
Author(s):  
Katrin S Huettl ◽  
Annette M Staiger ◽  
Heike Horn ◽  
Fabian Frontzek ◽  
John R Goodlad ◽  
...  
Keyword(s):  
Plasmablastic Lymphoma ◽  
Diagnostic Pitfall ◽  
Routine Work ◽  
Cytokeratin Expression ◽  
Work Up

scholarly journals Practicability and Diagnostic Yield of One-Stop Stroke CT with Delayed-Phase Cardiac CT in Detecting Major Cardioembolic Sources of Acute Ischemic Stroke

2021 ◽  
Author(s):  
Friederike Austein ◽  
Matthias Eden ◽  
Jakob Engel ◽  
Annett Lebenatus ◽  
Naomi Larsen ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Early Stage ◽  
Recurrent Stroke ◽  
Cardiac Computed Tomography ◽  
Standard Of Care ◽  
Routine Work ◽  
One Stop ◽  
Work Up ◽  
Delayed Phase ◽  
Multimodal Ct

Abstract Purpose Recurrent stroke is considered to increase the incidence of severe disability and death. For correct risk assessment and patient management it is essential to identify the origin of stroke at an early stage. Transthoracic echocardiography (TTE) is the initial standard of care for evaluating patients in whom a cardioembolic source of stroke (CES) is suspected but its diagnostic capability is limited. Transesophageal echocardiography (TEE) is considered as gold standard; however, this approach is time consuming, semi-invasive and not always feasible. We hypothesized that adding a delayed-phase cardiac computed tomography (cCT) to initial multimodal CT might represent a valid alternative to routine clinical echocardiographic work-up. Material and Methods Patients with suspected acute cardioembolic stroke verified by initial multimodal CT and subsequently examined with cCT were included. The cCT was evaluated for presence of major CES and compared to routine clinical echocardiographic work-up. Results In all, 102 patients with suspected acute CES underwent cCT. Among them 60 patients underwent routine work-up with echocardiography (50 TTE and only 10 TEE). By cCT 10/60 (16.7%) major CES were detected but only 4 (6.7%) were identified by echocardiography. All CES observed by echocardiography were also detected by cCT. In 8 of 36 patients in whom echocardiography was not performed cCT also revealed a major CES. Conclusion These preliminary results show the potential diagnostic yield of delayed-phase cCT to detect major CES and therefore could accelerate decision-making to prevent recurrence stroke. To confirm these results larger studies with TEE as the reference standard and also compared to TTE would be necessary.

Numbers of host "helper" T cells and proliferating cells predict survival in diffuse small-cell lymphomas.

1989 ◽  
Vol 7 (8) ◽  
pp. 1009-1017 ◽  
Author(s):  
L J Medeiros ◽  
L J Picker ◽  
A B Gelb ◽  
J G Strickler ◽  
S W Brain ◽  
...  
Keyword(s):  
Patient Survival ◽  
T Antigen ◽  
Small Cell ◽  
Proliferating Cells ◽  
Actuarial Survival ◽  
Ki 67 ◽  
Lymphoid Malignancies ◽  
Routine Work ◽  
B Lineage ◽  
Work Up

Diffuse small-cell lymphomas of B-lineage comprise a group of immunophenotypically related lymphoid malignancies that display variable clinical aggressiveness. We compared a variety of clinical, pathologic, and immunologic characteristics of 64 B-lineage diffuse small-cell lymphomas to patient survival in an effort to define prognostically relevant subtypes of these neoplasms. Neither clinical parameters nor histological subclassification correlated with patient outcome. In contrast, three immunologic features of these lymphomas showed a statistically significant relationship with actuarial survival. Neoplasms that manifested greater than or equal to 25% Ki-67+ cells (proliferation-associated antigen), less than 25% Leu 4+ cells (pan-T antigen), or less than 15% Leu 3+ cells (helper/inducer T-subset antigen) were associated with significantly decreased patient survival as compared to neoplasms with the reverse phenotype (P = .02, P = .003, P = .0005, respectively). Leu 3 findings were of particular importance in initial biopsies (P = .0007), while the Ki-67 findings were significant regardless of time of biopsy (P = .01 for biopsies at diagnosis and P = .004 for other biopsies). These data indicate that immunologic analysis can demonstrate subsets of diffuse small-cell lymphoma with different biologic potential, and suggest that such analysis be included in the routine work-up of patients with this type of neoplasm.

scholarly journals Venous Doppler in the Evaluation of Fetal Hydrops

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
C. Hofstaetter ◽  
S. Gudmundsson
Keyword(s):  
Doppler Sonography ◽  
Umbilical Vein ◽  
Venous Blood ◽  
Blood Velocity ◽  
Ductus Venosus ◽  
Venous Blood Flow ◽  
Fetal Hydrops ◽  
Routine Work ◽  
The Right ◽  
Work Up

Objective. To examine venous blood flow velocity in different types of fetal hydrops and its value in the prediction of outcome of pregnancies.Methods. Venous Doppler sonography was performed in 100 hydropic fetuses from 15 to 37 weeks of gestation. Blood velocity was recorded in the right hepatic vein (HV), the ductus venosus (DV) and in the intra-abdominal part of the umbilical vein (UV). Blood velocity indices were calculated and pulsations in the umbilical vein noted and grouped into a single, double or triple flow pattern. Blood velocity was related to cause of hydrops.Results. Mortality was noted in 51 cases of which 19 were by termination of pregnancy. Mortality in the 30 with normal venous blood velocity was 35%, but 58% in cases of abnormal Doppler. Abnormal HV and DV blood velocities were recorded in 39 and 34 cases, respectively and were strongly related to mortality ( and , resp.). UV pulsations were noted in 49 fetuses and were significantly related to mortality (). Mortality and abnormal venous velocities were most frequent in the low-output hydrops group (79% and 75%, resp.).Conclusions. Abnormal venous blood velocity is related to mortality in pregnancies complicated by fetal hydrops. Venous Doppler sonography should be a part of the routine work-up of pregnancies complicated by fetal hydrops.

scholarly journals P.097 Safety of intrarterial reopro in thrombotic complications during coiling

2016 ◽  
Vol 43 (S2) ◽  
pp. S43-S43
Author(s):  
R Martinez-Perez ◽  
M Boulton ◽  
M Sharma
Keyword(s):  
Cerebral Angiography ◽  
Ruptured Aneurysm ◽  
Thrombotic Complication ◽  
Parent Vessel ◽  
Arterial Infusion ◽  
Routine Work ◽  
Distal Migration ◽  
Thrombotic Complications ◽  
Potential Risks ◽  
Work Up

Background: Abciximab is used for the treatment of thromboembolism occuring during endovascular procedures, however the experience with intra-arterial infusion is limited. The objective is to evaluate its safety and effectiveness during coiling complications. Methods: From an aneurysm coiling database, patients treated with intra-arterial abciximab due to thrombotic complications were selected. Patient were classified either as non-ruptured aneurysm for elective coiling or presenting with subarachnoid hemorrhage. They all had preand post-procedure cerebral angiography performed at our institution as part of routine work-up. Success rate was based on recanalization seen on cerebral angiography. Complications of using abciximab were reported. Results: 35 of 441 coiling patients had a thrombotic complication. 13 of them were treated using intra-arterial infusion of abciximab. 2 patients were male, median age 59. 6 patients presented with sub-arachnoid haemorrhage. 84 % of patients had at least partial recanalization, while 38 % experienced complete recanalization of the parent vessel. 45 % of patients had complications, none severe. 2 patients had aneurysm recanalization, 3 distal migration of thrombus and 1 had haemorrhage (non ruptured aneurysm). Conclusions: Inspite of being considered a safer alternative, use of intrarterial abciximab has potential risks, including hemorrhage, distal thromboembolism and aneurysm recanalization.

Sign in / Sign up

Export Citation Format

Share Document