The diagnostic ability of high‐fluorescent cells combined with carcinoembryonic antigen for malignant pleural effusion

The differential diagnosis of malignant pleural effusion and benign pleural effusion remains a clinical problem. Reactive oxygen species modulator 1 is a novel protein overexpressed in various human tumors. The objective of this study was to evaluate the diagnostic value of joint detection of reactive oxygen species modulator 1 and carcinoembryonic antigen in the differential diagnosis of malignant pleural effusion and benign pleural effusion. One hundred two consecutive patients with pleural effusion (including 52 malignant pleural effusion and 50 benign pleural effusion) were registered in this study. Levels of reactive oxygen species modulator 1 and carcinoembryonic antigen were measured by enzyme-linked immunosorbent assay and radioimmunoassay, respectively. Results showed that the concentrations of reactive oxygen species modulator 1 both in pleural fluid and serum of patients with malignant pleural effusion were significantly higher than those of benign pleural effusion (both p < 0.05). The diagnostic sensitivity and specificity of pleural fluid reactive oxygen species modulator 1 were 61.54% and 82.00%, respectively, with the optimized cutoff value of 589.70 pg/mL. However, the diagnostic sensitivity and specificity of serum reactive oxygen species modulator 1 were only 41.38% and 86.21%, respectively, with the cutoff value of 27.22 ng/mL, indicating that serum reactive oxygen species modulator 1 may not be a good option in the differential diagnosis of malignant pleural effusion and benign pleural effusion. The sensitivity and specificity of pleural fluid carcinoembryonic antigen were 69.23% and 88.00%, respectively, at the cutoff value of 3.05 ng/mL, while serum carcinoembryonic antigen were 80.77% and 72.00% at the cutoff value of 2.60 ng/mL. The sensitivity could be raised to 88.17% in parallel detection of plural fluid reactive oxygen species modulator 1 and carcinoembryonic antigen concentration, and the specificity could be improved to 97.84% in serial detection.

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Diagnostic value of cyfra 21-1 and carcinoembryonic antigen in differentiation between benign and malignant pleural effusion

Egyptian Journal of Chest Diseases and Tuberculosis ◽

10.1016/j.ejcdt.2015.02.001 ◽

2015 ◽

Vol 64 (2) ◽

pp. 411-417

Author(s):

Waffa S. El-Shimy ◽

Basem I. El-Shafey ◽

Hesham A. El-Sorougy ◽

Eman Ali Abd El-Monem

Keyword(s):

Pleural Effusion ◽

Carcinoembryonic Antigen ◽

Malignant Pleural Effusion ◽

Diagnostic Value

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Ratio of carcinoembryonic antigen in pleural fluid and serum for the diagnosis of malignant pleural effusion

Therapeutic Advances in Medical Oncology ◽

10.1177/1758835919850341 ◽

2019 ◽

Vol 11 ◽

pp. 175883591985034 ◽

Cited By ~ 5

Author(s):

Klaus Hackner ◽

Peter Errhalt ◽

Sabin Handzhiev

Keyword(s):

Pleural Effusion ◽

Carcinoembryonic Antigen ◽

Pleural Fluid ◽

Predictive Value ◽

Malignant Pleural Effusion ◽

Diagnostic Value ◽

Tumour Markers ◽

Operating Characteristics ◽

Characteristics Analysis ◽

Individual Marker

Background: Tumour markers in pleural fluid and their diagnostic value are subject to debate. Although there are several studies on this topic, standardized cut-off values do not exist. In this study we investigated the potential of a ratio of carcinoembryonic antigen (CEA) in pleural fluid and serum, serving as an individual marker for pleural cancer manifestation. Methods: A total of 201 consecutive patients with unclear pleural effusion were included in the study; 98 were diagnosed with malignant pleural effusion and 103 had an effusion due to other, benign reasons. CEA levels in pleural fluid and serum were measured. Results: By using receiver operating characteristics analysis, at the cut-off of 1.0, the CEA ratio showed a specificity of 92% and sensitivity of 85%, with a positive predictive value of 91% and a negative predictive value of 87%. These results are higher than in previous investigations on different pleural tumour markers and their combination. Conclusions: The CEA ratio is a useful tool in predicting pleural carcinosis. Elevated results in cytology-negative patients should lead to further investigations, such as repeated cytological examination or thoracoscopy.

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Diagnostic Potential of Carcinoembryonic Antigen and Ferritine in Tuberculous and Malignant Pleural Effusion

Tumori Journal ◽

10.1177/030089169508100612 ◽

1995 ◽

Vol 81 (6) ◽

pp. 440-444 ◽

Cited By ~ 2

Author(s):

Robert Loncar ◽

Ljerka Ostojic ◽

Vera Tabakovic-Loncar ◽

Ante Roguljić

Keyword(s):

Pleural Effusion ◽

Carcinoembryonic Antigen ◽

Sensitivity And Specificity ◽

Malignant Pleural Effusion ◽

Bayes Theorem ◽

Diagnostic Value ◽

Physical Status ◽

Predictive Values ◽

Diagnostic Potential ◽

Significant Difference

The aim of the study was to determine the diagnostic value of carcinoembryonic antigen (CEA) and ferritine in malignant and tuberculous non-bloody pleural effusion. The etiology of diseases was determined by cytologic, histologic and microbiologic methods. CEA concentration above 5 ng/ml and ferritine concentration above 200 ng/ml were considered to be positive. There was significant difference in the value of CEA measured in malignant and in tuberculous pleural effusion (P < 0.005) as well as in the sera (P < 0.01) of these two groups. There was no correlation between concentration of CEA and ferritine in malignant pleural effusion. Ratio between CEA and ferritine in effusions and sera was of no help in discrminating malignant from tuberculous effusions. No correlation between examined markers and physical status of patients was observed. The sensitivity and specificity of CEA assay in malignant pleural effusion was 65% and 90%, respectively, and for ferritine 67% and 80%, respectively. A high correlation was observed between the CEA concentration in malignant pleural effusion and sera patients (r = 0.95). Combined sensitivity and specificity of CEA and ferritine was 65.9% and 85%. Bayes theorem was used to calculate the positive predictive values for CEA and ferritine, which were 53% and 37%, respectively. Results obtained in the study show the relatively good diagnostic potential of CEA.

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