Recurrent life-threatening reactions to platelet transfusion in an aplastic anaemia patient with a paroxysmal nocturnal haemoglobinuria clone

2014 ◽  
Vol 44 (9) ◽  
pp. 925-927
Author(s):  
M. Mohamed ◽  
G. Bates ◽  
D. Richardson ◽  
L. Burrows
Keyword(s):  
Aplastic Anaemia ◽  
Platelet Transfusion ◽  
Paroxysmal Nocturnal Haemoglobinuria ◽  
Life Threatening ◽  
Paroxysmal Nocturnal Haemoglobinuria Clone

scholarly journals TransientJAK2V617F mutation in an aplastic anaemia patient with a paroxysmal nocturnal haemoglobinuria clone

2013 ◽  
Vol 161 (2) ◽  
pp. 297-298 ◽  
Author(s):  
Stephen E. Langabeer ◽  
Karl Haslam ◽  
David O'Brien ◽  
Helen Enright ◽  
Maeve Leahy
Keyword(s):  
Aplastic Anaemia ◽  
Paroxysmal Nocturnal Haemoglobinuria ◽  
Paroxysmal Nocturnal Haemoglobinuria Clone

scholarly journals Management of thrombosis in paroxysmal nocturnal hemoglobinuria: a clinician’s guide

2016 ◽  
Vol 8 (3) ◽  
pp. 119-126 ◽  
Author(s):  
Morag Griffin ◽  
Talha Munir
Keyword(s):  
Bone Marrow ◽  
Median Survival ◽  
Paroxysmal Nocturnal Hemoglobinuria ◽  
Bone Marrow Failure ◽  
Paroxysmal Nocturnal Haemoglobinuria ◽  
Orphan Disease ◽  
Life Threatening

Paroxysmal nocturnal haemoglobinuria (PNH), an ultra-orphan disease with a prevalence of 15.9 per million in Europe, is a life-threatening disorder, characterized by haemolysis, bone marrow failure and thrombosis. Patients with PNH prior to the availability of eculizumab had a median survival of between 10 and 22 years, with thrombosis accounting for 22–67% of deaths. 29–44% of patients had at least one thrombosis. This paper provides a clinician’s guide to the diagnosis, management and complications of PNH, with an emphasis on thrombosis.

Aplastic anaemia and paroxysmal nocturnal haemoglobinuria: a study of the GPI-anchored proteins on human platelets

1996 ◽  
Vol 93 (3) ◽  
pp. 586-589 ◽  
Author(s):  
T. Vu ◽  
A. Griscelli-Bennaceur ◽  
E. Gluckman ◽  
F. Sigaux ◽  
E. D. Carosella ◽  
...  
Keyword(s):  
Aplastic Anaemia ◽  
Human Platelets ◽  
Paroxysmal Nocturnal Haemoglobinuria

Cell Cycling Stress in the Monocyte Line as a Risk Factor for Progression of the Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Syndrome to Myelodysplastic Syndrome

2000 ◽  
Vol 103 (1) ◽  
pp. 33-40 ◽  
Author(s):  
Catherine Nissen ◽  
Alexander Genitsch ◽  
Silvia Sendelov ◽  
Verena Dalle Carbonare ◽  
Aleksandra Wodnar-Filipowicz
Keyword(s):  
Risk Factor ◽  
Myelodysplastic Syndrome ◽  
Aplastic Anaemia ◽  
Paroxysmal Nocturnal Haemoglobinuria ◽  
Cell Cycling
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