Different Consequences of β1 Integrin Deletion in Neonatal and Adult Mouse Epidermis Reveal a Context-Dependent Role of Integrins in Regulating Proliferation, Differentiation, and Intercellular Communication

Asch’s seminal research on “Forming Impressions of Personality” (1946) has widely been cited as providing evidence for a primacy-of-warmth effect, suggesting that warmth-related judgments have a stronger influence on impressions of personality than competence-related judgments (e.g., Fiske, Cuddy, & Glick, 2007 ; Wojciszke, 2005 ). Because this effect does not fit with Asch’s Gestalt-view on impression formation and does not readily follow from the data presented in his original paper, the goal of the present study was to critically examine and replicate the studies of Asch’s paper that are most relevant to the primacy-of-warmth effect. We found no evidence for a primacy-of-warmth effect. Instead, the role of warmth was highly context-dependent, and competence was at least as important in shaping impressions as warmth.

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The Role of Chemical Inhibition of Gap-Junctional Intercellular Communication in Toxicology

10.21236/ada221480 ◽

1990 ◽

Author(s):

James E. Trosko

Keyword(s):

Intercellular Communication ◽

Gap Junctional Intercellular Communication ◽

Chemical Inhibition ◽

Gap Junctional

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Evolution of the hedgehog Gene Family

Genetics ◽

10.1093/genetics/142.3.965 ◽

1996 ◽

Vol 142 (3) ◽

pp. 965-972 ◽

Cited By ~ 2

Author(s):

Sudhir Kumar ◽

Kristi A Balczarek ◽

Zhi-Chun Lai

Keyword(s):

Intercellular Communication ◽

Short Range ◽

Gene Duplications ◽

Future Directions ◽

Amino Terminal ◽

Terminal Fragment ◽

Carboxyl Terminal ◽

Multicellular Organisms ◽

Amino Terminal Fragment

Abstract Effective intercellular communication is an important feature in the development of multicellular organisms. Secreted hedgehog (hh) protein is essential for both long- and short-range cellular signaling required for body pattern formation in animals. In a molecular evolutionary study, we find that the vertebrate homologs of the Drosophila hh gene arose by two gene duplications: the first gave rise to Desert hh, whereas the second produced the Indian and Sonic hh genes. Both duplications occurred before the emergence of vertebrates and probably before the evolution of chordates. The amino-terminal fragment of the hh precursor, crucial in long- and short-range intercellular communication, evolves two to four times slower than the carboxyl-terminal fragment in both Drosophila hh and its vertebrate homologues, suggesting conservation of mechanism of hh action in animals. A majority of amino acid substitutions in the amino- and carboxyl-terminal fragments are conservative, but the carboxyl-terminal domain has undergone extensive insertion-deletion events while maintaining its autocleavage protease activity. Our results point to similarity of evolutionary constraints among sites of Drosophila and vertebrate hh homologs and suggest some future directions for understanding the role of hh genes in the evolution of developmental complexity in animals.

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