Regulation of Junctional Intercellular Communication by Tyrosine-Protein Kinases. Role of the Cellular Src Gene and Growth Factor Receptors

1991 ◽  
pp. 425-436
Author(s):  
Werner R. Loewenstein
Keyword(s):  
Growth Factor ◽  
Protein Kinases ◽  
Intercellular Communication ◽  
Growth Factor Receptors ◽  
Src Gene

CS11-1. Role of the tyrosine Kinase FER in the activation of NFkappaB by mutated growth factor receptors in cancer

Cytokine ◽  
2011 ◽  
Vol 56 (1) ◽  
pp. 60
Author(s):  
Canhui Guo ◽  
Anu Gupta ◽  
Sarmishtha De ◽  
Brian P. Rubin ◽  
George R. Stark
Keyword(s):  
Growth Factor ◽  
Tyrosine Kinase ◽  
Growth Factor Receptors

Abstract 5296: The role of SOCS-1 in stimulating melanoma development through growth factor receptors and MAPK pathways

2014 ◽  
Author(s):  
Rodrigo Berzaghi ◽  
Felipe V. Pereira ◽  
Vera S.C. Maia ◽  
Jorge B. Scutti ◽  
Luiz R. Travassos
Keyword(s):  
Growth Factor ◽  
Growth Factor Receptors ◽  
Mapk Pathways

scholarly journals Role of Growth Factor Receptors in Neural Stem Cells Differentiation and Dopaminergic Neurons Generation

10.5772/31099 ◽  
2012 ◽  
Author(s):  
Luca Calatrava ◽  
Rafael Gonzalo-Gobernado ◽  
Antonio S. ◽  
Diana Reimers ◽  
Maria J. ◽  
...  
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Dopaminergic Neurons ◽  
Growth Factor Receptors

The role of EGFR trafficking in neuroblastoma

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 20003-20003
Author(s):  
P. E. Zage ◽  
Q. Yan ◽  
L. Zeng ◽  
A. J. Bean
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
Cell Lines ◽  
Neuroblastoma Cell ◽  
Growth Factor Receptor ◽  
Growth Factor Receptors ◽  
Human Neuroblastoma ◽  
Degradation Rates ◽  
Neuroblastoma Cell Lines

20003 Background: Signaling through growth factor receptors is important in neuroblastoma pathogenesis. Chromosome 1p36 is commonly deleted in neuroblastoma tumors and is associated with a poor prognosis. UBE4B, a gene in 1p36, has been reported mutated in high- risk neuroblastoma. We have found a direct interaction between UBE4B and hrs, a protein required for epidermal growth factor receptor (EGFR) trafficking, suggesting a link between EGFR trafficking and neuroblastoma pathogenesis. We have analyzed the role of UBE4B in the EGFR pathway in neuroblastoma cell lines. Methods: The expression of UBE4B, hrs and EGFR were analyzed by quantitative Western blot in a panel of 7 human neuroblastoma cell lines (SHEP, SKNAS, SKNSH, KCNR, SY5Y, LA155N, NGP). EGFR degradation rates were determined by examining the kinetics of cellular EGFR depletion following a pulse of ligand. Results: UBE4B levels were lowest in SKNAS and highest in NGP cells. Hrs levels were lowest in SKNSH cells and higher in other cell lines. EGFR levels were lowest in NGP and KCNR and highest in SKNAS cells. UBE4B levels were correlated with known 1p deletions. EGFR degradation rates were slowest in SKNAS cells and therefore correlated with cellular UBE4B levels. The low degradation rates were correlated with high cellular levels of EGFR. Conclusions: Expression levels of UBE4B are correlated in neuroblastoma cell lines with chromosome 1p deletions. Cell lines with lower levels of UBE4B degrade EGFR at a markedly slower rate, correlated with higher cellular EGFR levels. We hypothesize that UBE4B affects cell growth by interacting with hrs, directing EGFR for degradation. In its absence the ability of a cell to sort growth factor receptors for degradation is inhibited, resulting in growth factor receptor overabundance and uncontrolled cell growth. These results support the testing of EGFR inhibitors in a future phase I trial for children with neuroblastoma. No significant financial relationships to disclose.

MP52-18 ROLE OF FIBROBLAST GROWTH FACTOR RECEPTORS IN LEYDIG CELL DEVELOPMENT

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Andres Correa ◽  
Kenneth Walker ◽  
Daniel Bushnel ◽  
Caitlin Schaefer ◽  
Julia Schaffer ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Leydig Cell ◽  
Growth Factor Receptors ◽  
Cell Development ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor Receptors
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