Chapter VI.: 4. Determination of the total blood volume

2009 ◽  
Vol 139 (S256) ◽  
pp. 28-31
Keyword(s):  
Blood Volume ◽  
Total Blood Volume ◽  
Total Blood

Simultaneous determination of blood volume with Cr51 and T-1824 during hypothermia and rewarming

1959 ◽  
Vol 196 (4) ◽  
pp. 703-705 ◽  
Author(s):  
E. J. Fedor ◽  
B. Fisher
Keyword(s):  
Cell Volume ◽  
Simultaneous Determination ◽  
Blood Volume ◽  
Plasma Volume ◽  
Red Cell ◽  
Total Blood Volume ◽  
Total Blood ◽  
Red Cell Volume ◽  
Usual Feature

Dogs lightly anesthetized with ether, maintained between 23–24°C for 2 hours and rewarmed, were subjected to simultaneous determinations of red cell volume (Cr51) and plasma volume (T-1824). Red cell volume values were unchanged during the course of the experiment. Plasma volumes were significantly decreased during hypothermia and were transiently elevated during rewarming. Twenty-four hours after rewarming, total blood volume and plasma volume values were not significantly different from control values. It would seem that circulatory failure (‘rewarming shock’) is not a usual feature of rewarming following hypothermia of 2 hours duration.

A588 DETERMINATION OF TOTAL BLOOD VOLUME (TBV) FROM CARDIAC OUTPUT AND MEAN CIRCULATION TIME

1997 ◽  
Vol 87 (Supplement) ◽  
pp. 588A
Author(s):  
Gotz Wietasch ◽  
Thomas Scheeren ◽  
Andreas Hoeft ◽  
Joachim O. Arndt
Keyword(s):  
Cardiac Output ◽  
Blood Volume ◽  
Circulation Time ◽  
Total Blood Volume ◽  
Total Blood ◽  
Mean Circulation

Observations on Cardiac Output and ”Pulmonary Blood Volume” in Normal Man by External Recording of the Intracardiac Flow of 131I Labelled Albumin

1961 ◽  
Vol 1 (04) ◽  
pp. 353-379
Author(s):  
Jacques Lammerant ◽  
Norman Veall ◽  
Michel De Visscher
Keyword(s):  
Cardiac Output ◽  
Blood Volume ◽  
Normal Subjects ◽  
Published Data ◽  
Total Blood Volume ◽  
Total Blood ◽  
Pulmonary Blood Volume ◽  
Intracardiac Flow ◽  
Normal Man ◽  
Mean Circulation

Summary1. The technique for the measurement of cardiac output by external recording of the intracardiac flow of 131I labelled human serum albumin has been extended to provide a measure of the mean circulation time from right to left heart and hence a new approach to the estimation of the pulmonary blood volume.2. Values for the basal cardiac output in normal subjects and its variations with age are in good agreement with the previously published data of other workers.3. The pulmonary blood volume in normal man in the basal state was found to be 28.2 ± 0.6% of the total blood volume.4. There was no correlation between cardiac output and pulmonary blood volume in a series of normal subjects in the basal state.5. The increase in cardiac output during digestion was associated with a decrease in pulmonary blood volume equal to 6.3 ± 1.2% of the total blood volume, that is, about 280 ml.6. The increase in cardiac output during exercise was associated with a decrease in pulmonary blood volume equal to 4.5 ± 1.0% of the total blood volume, that is, about 200 ml.7. The increase in cardiac output attributed to alarm is not associated with a decrease in pulmonary blood volume, the latter may in fact be increased.8. The total blood volume is advocated as a standard of reference for studies of this type in normal subjects in preference to body weight or surface area.9. The significance of these results and the validity of the method are discussed.

Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs

1996 ◽  
Vol 81 (2) ◽  
pp. 895-904 ◽  
Author(s):  
M. F. Humer ◽  
P. T. Phang ◽  
B. P. Friesen ◽  
M. F. Allard ◽  
C. M. Goddard ◽  
...  
Keyword(s):  
Blood Volume ◽  
Transit Time ◽  
Volume Flow ◽  
Oxygen Extraction ◽  
Control Group ◽  
Total Blood Volume ◽  
Oxygen Extraction Ratio ◽  
Total Blood ◽  
Transit Times ◽  
Critical Oxygen

We tested the hypothesis that endotoxin increases the heterogeneity of gut capillary transit times and impairs oxygen extraction. The gut critical oxygen extraction ratio was determined by measuring multiple oxygen delivery-consumption points during progressive phlebotomy in eight control and eight endotoxin-infused anesthetized pigs. In multiple 1- to 2-g samples of small bowel, we measured blood volume (radiolabeled red blood cells) and flow (radiolabeled 15-microns microspheres) before and after critical oxygen extraction. Red blood cell transit time (= volume/flow) multiplied by morphologically determined capillary/total blood volume gave capillary transit time. During hemorrhage, capillary/total blood volume did not change in the endotoxin group (0.5 +/- 4.5%) but increased in the control group (17.6 +/- 2.5%; P < 0.05) due to a decrease in total gut blood volume. Flow decreased significantly in the endotoxin group (36 +/- 10%; P < 0.05) but not in the control group (12 +/- 10%). Capillary transit-time heterogeneity increased in the endotoxin group (12.3 +/- 4.9%) compared with the control group (-5.8 +/- 7.4%; P < 0.05), predicting a critical oxygen extraction ratio 0.14 lower in the endotoxin group than in the control group (K. R. Walley. J. Appl. Physiol. 81: 885–894, 1996). This matches the measured difference (endotoxin group, 0.60 +/- 0.04; control group, 0.74 +/- 0.03; P < 0.05). Increased heterogeneity of capillary transit times may be an important cause of impaired oxygen extraction.

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