PYELONEPHRITIS-LIKE LESIONS AS A LATE EFFECT OF DIFFUSE INTRAVASCULAR COAGULATION

✓ The authors report the development of diffuse intravascular coagulation following massive cerebral trauma in a child. The importance of anticipating this complication is stressed and recommendations for early diagnosis and treatment are presented.

Download Full-text

Diffuse Intravascular Coagulation Versus Fibrinolysis

Postgraduate Medicine ◽

10.1080/00325481.1972.11698219 ◽

1972 ◽

Vol 51 (4) ◽

pp. 215-218 ◽

Cited By ~ 5

Author(s):

John B. Henry ◽

Mario Stefanini

Keyword(s):

Intravascular Coagulation ◽

Diffuse Intravascular Coagulation

Download Full-text

Heparin Therapy of Diffuse Intravascular Coagulation (DIC)

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647819 ◽

1975 ◽

Vol 33 (01) ◽

pp. 105-106 ◽

Cited By ~ 11

Author(s):

H. G Lasch ◽

D. H Heene

Keyword(s):

Heparin Therapy ◽

Intravascular Coagulation ◽

Diffuse Intravascular Coagulation

Download Full-text

Causes of a Negative Ethanol Gelation Test in Diffuse Intravascular Coagulation

Thrombosis and Haemostasis ◽

10.1055/s-0038-1649164 ◽

1974 ◽

Vol 31 (02) ◽

pp. 299-308 ◽

Cited By ~ 5

Author(s):

W. B. J Gerrits ◽

Elisabeth M Prakke ◽

J van der Meer ◽

J Vreeken

Keyword(s):

Fibrinogen Level ◽

Degradation Products ◽

Laboratory Data ◽

Aminocaproic Acid ◽

Plasmin Activity ◽

Clinical Value ◽

Intravascular Coagulation ◽

Diffuse Intravascular Coagulation ◽

Gelation Test

SummaryThe clinical value of the ethanol gelation test (EGT) in diagnosing diffuse intravascular coagulation (DIC) has been questioned because of the occasional finding of a negative test, while other laboratory data pointed to DIC. Therefore, the behaviour of the EGT during thrombin infusions in rabbits was studied, with special reference to the fibrinogen level and activation of fibrinolysis. Fibrinolytic activity was inhibited or induced by synchronous infusion of epsilon-aminocaproic acid or plasmin respectively. The results obtained show that apart from severe depletion of fibrinogen strong activation of fibrinolysis can cause a negative EGT during thrombin infusions in rabbits. This phenomenon could not be ascribed to high levels of fibrin degradation products (fdp); it might be due to plasmin digestion of fibrin monomers. In vitro studies with human plasma confirmed that the EGT becomes negative at a fibrinogen level of less than 20 mg per 100 ml or by plasmin activity in the presence of a normal fibrinogen level.Whereas a positive EGT is highly specific for DIC, these studies show that a negative EGT does not exclude the presence of DIC.

Download Full-text