Vasospastic Ischaemia Induced by the Hyperventilation Test in Patients with a Negative Response to Ergometrine

2009 ◽  
Vol 218 (2) ◽  
pp. 241-244 ◽  
Author(s):  
KLAUS RASMUSSEN ◽  
JENS PEDER BAGGER
Keyword(s):  
Negative Response ◽  
Hyperventilation Test

Learning from tragedy–The Jessica Barnett story: challenges in the diagnosis of long QT syndrome

Diagnosis ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Mark L. Graber ◽  
Andrew P. J. Olson ◽  
Tanya Barnett
Keyword(s):  
Anxiety Disorder ◽  
Long Qt Syndrome ◽  
Adolescent Girl ◽  
Ventricular Cardiomyopathy ◽  
Long Qt ◽  
Genetic Studies ◽  
The Family ◽  
Qt Syndrome ◽  
Hyperventilation Test ◽  
Congenital Long Qt Syndrome

Abstract We describe the case of Jessica Barnett, an adolescent girl whose repeated episodes of syncope and near-syncope were ascribed to a seizure or anxiety disorder. The correct diagnoses (congenital long QT syndrome; arrythmogenic right ventricular cardiomyopathy) were established by autopsy and genetic studies only after her death at age 17. The perspective of the family is presented, along with an analysis of what went right and what went wrong in Jessica’s diagnostic journey. Key lessons in this case include the value of family as engaged members of the diagnostic team, that a ‘hyperventilation test’ should not be used to exclude cardiac origins of syncope or pre-syncope, and the inherent challenges in the diagnosis of the long QT syndrome.

Patanjali Ayurved Limited’s Skin Ailment Advertisement: What Have We Learnt?

2020 ◽  
pp. 231971452092517
Author(s):  
Vinod Kumar ◽  
Vandana ◽  
Moulik Wason
Keyword(s):  
Social Media ◽  
Crisis Management ◽  
Management Strategy ◽  
Communication Strategy ◽  
Negative Response ◽  
Young Generation ◽  
Marketing Communication ◽  
Print Advertisement ◽  
Dark Complexion ◽  
Media Channels

On 7 January 2018, Patanjali Ayurved Limited (PAL) published a print advertisement (ad) mentioning dark complexion as a skin ailment. This ad caught the eye of the young generation of India who is intolerant towards any kind of discrimination. People started giving their opinion about this ad and the issue was picked on social media channels such as Twitter, online blogs, news sites, etc. Users of social media clearly expressed their unacceptance towards the content of the ad. PAL tried to pacify the crowd by sending their spokesperson’s reply on Twitter. Seeing the continuous negative response, Baba Ramdev, co-founder and brand ambassador of PAL, responded on the next day in order to bring the situation under control. In such a scenario, PAL is analysing the entire incident and planning to revisit its marketing communication strategy. PAL is thinking not only to avoid such a situation but also to devise a better crisis management strategy for the future.

scholarly journals Climate effects on the onset of flowering in the United Kingdom

2019 ◽  
Vol 31 (1) ◽  
Author(s):  
Nigel Fox ◽  
Anna Maria Jönsson
Keyword(s):  
Climate Change ◽  
Time Series ◽  
United Kingdom ◽  
Response Rates ◽  
Extreme Weather ◽  
Extreme Weather Event ◽  
Negative Response ◽  
Wild Plant ◽  
Weather Event ◽  
The United Kingdom

Abstract Background A warmer climate has consequences for the timing of phenological events, as temperature is a key factor controlling plant development and flowering. In this study, we analyse the effects of the long-term climate change and an extreme weather event on the first flowering day (FFD) of five spring-flowering wild plant species in the United Kingdom. Citizen science data from the UK Woodland Trust were obtained for five species: Tussilago farfara (coltsfoot), Anemone nemorosa (wood anemone), Hyacinthoides non-scripta (bluebell), Cardamine pratensis (cuckooflower) and Alliaria petiolate (garlic mustard). Results Out of the 351 site-specific time series (≥ 15-years of FFD records), 74.6% showed significant negative response rates, i.e. earlier flowering in warmer years, ranging from − 5.6 to − 7.7 days °C−1. 23.7% of the series had non-significant negative response rates, and 1.7% had non-significant positive response rates. For cuckooflower, the response rate was increasingly more negative with decreasing latitudes. The winter of 2007 reflects an extreme weather event, about 2 °C warmer compared to 2006, where the 2006 winter temperatures were similar to the 1961–1990 baseline average. The FFD of each species was compared between 2006 and 2007. The results showed that the mean FFD of all species significantly advanced between 13 and 18 days during the extreme warmer winter of 2007, confirming that FFD is affected by temperature. Conclusion Given that all species in the study significantly respond to ambient near-surface temperatures, they are suitable as climate-change indicators. However, the responses to a + 2 °C warmer winter were both more and less pronounced than expected from an analysis of ≥ 15-year time series. This may reflect non-linear responses, species-specific thresholds and cumulative temperature effects. It also indicates that knowledge on extreme weather events is needed for detailed projections of potential climate change effects.

Time Course of Cross-Orientation Suppression in the Early Visual Cortex

2009 ◽  
Vol 101 (3) ◽  
pp. 1463-1479 ◽  
Author(s):  
Rui Kimura ◽  
Izumi Ohzawa
Keyword(s):  
Visual Cortex ◽  
Time Course ◽  
Individual Component ◽  
Correlation Method ◽  
Suppressive Effect ◽  
Negative Response ◽  
Reverse Correlation ◽  
Response Onset ◽  
Early Visual Cortex ◽  
Visual Neuron

Responses of a visual neuron to optimally oriented stimuli can be suppressed by a superposition of another grating with a different orientation. This effect is known as cross-orientation suppression. However, it is still not clear whether the effect is intracortical in origin or a reflection of subcortical processes. To address this issue, we measured spatiotemporal responses to a plaid pattern, a superposition of two gratings, as well as to individual component gratings (optimal and mask) using a subspace reverse-correlation method. Suppression for the plaid was evaluated by comparing the response to that for the optimal grating. For component stimuli, excitatory and negative responses were defined as responses more positive and negative, respectively, than that to a blank stimulus. The suppressive effect for plaids was observed in the vast majority of neurons. However, only ∼30% of neurons showed the negative response to mask-only gratings. The magnitudes of negative responses to mask-only stimuli were correlated with the degree of suppression for plaid stimuli. Comparing the latencies, we found that the suppression for the plaids starts at about the same time or slightly later than the response onset for the optimal grating and reaches its maximum at about the same time as the peak latency for the mask-only grating. Based on these results, we propose that in addition to the suppressive effect originating at the subcortical stage, delayed suppressive signals derived from the intracortical networks act on the neuron to generate cross-orientation suppression.

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