Altered distribution of M2 and M4 muscarinic receptor expression in vitiligo

2010 ◽  
Vol 38 (5) ◽  
pp. 493-497
Author(s):  
Sirintip CHAICHALOTORNKUL ◽  
Montree UDOMPATAIKUL ◽  
Udomsri SHOWPITTAPORNCHAI ◽  
Piti PALUNGWACHIRA ◽  
Wisuit PRADIDARCHEEP
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Expression ◽  
M4 Muscarinic Receptor

scholarly journals Regulation of M3 Muscarinic Receptor Expression and Function by Transmembrane Protein 147

2010 ◽  
Vol 79 (2) ◽  
pp. 251-261 ◽  
Author(s):  
Erica Rosemond ◽  
Mario Rossi ◽  
Sara M. McMillin ◽  
Marco Scarselli ◽  
Julie G. Donaldson ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Transmembrane Protein ◽  
Receptor Expression ◽  
And Function ◽  
M3 Muscarinic Receptor

Development of a Radioligand, [3H]LY2119620, to Probe the Human M2 and M4 Muscarinic Receptor Allosteric Binding Sites

2014 ◽  
Vol 86 (1) ◽  
pp. 116-123 ◽  
Author(s):  
Douglas A. Schober ◽  
Carrie H. Croy ◽  
Hongling Xiao ◽  
Arthur Christopoulos ◽  
Christian C. Felder
Keyword(s):  
Muscarinic Receptor ◽  
Binding Sites ◽  
Allosteric Binding Sites ◽  
M4 Muscarinic Receptor

scholarly journals MP58-15 M2 AND M3 MUSCARINIC RECEPTOR EXPRESSION IN BLADDER TUMOR

2018 ◽  
Vol 199 (4S) ◽  
Author(s):  
Mehmet Kazim Asutay ◽  
Banu Aydin ◽  
Hasan Toper ◽  
Deniz Filinte ◽  
Hülya Cabadak ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Bladder Tumor ◽  
Receptor Expression ◽  
M3 Muscarinic Receptor

scholarly journals Characterization of Prejunctional Muscarinic Receptors: Effects on the Release of VIP and Functional Responses and Receptor Expression in the Ovine Submandibular Gland

2009 ◽  
Vol 2009 ◽  
pp. 1-6
Author(s):  
Anders T. Ryberg ◽  
Ondrej Soukup ◽  
Gunnar Tobin
Keyword(s):  
Electrical Stimulation ◽  
Submandibular Gland ◽  
Muscarinic Receptor ◽  
Muscarinic Receptors ◽  
Receptor Expression ◽  
Receptor Subtypes ◽  
Chorda Tympani Nerve ◽  
Functional Responses ◽  
Stimulation Of

In the in vivo experiments on anaesthetized sheep, it was presently examined whether muscarinic receptor antagonists with diverse selectivity affect the release of VIP in response to electrical stimulation of the parasympathetic chorda tympanic nerve differently, and if the changes in the release could be associated to altered secretory and vasodilator responses. The location of the muscarinic receptor subtypes was examined also. In the experiments, blood was collected out of the submandibular venous drainage before and during electrical stimulation of chorda tympani nerve in the absence and presence either of pirenzepine or methoctramine. While metchoctramine increased the output of protein, pirenzepine inhibited flow of saliva and increased protein output, vasodilatation, and VIP output. In morphological examinations, the inhibitory muscarinic M4 receptor occurred interacinarily in the gland. It is concluded that prejunctional muscarinic receptors, most likely of the M4 subtype, exert inhibitory modulation of the parasympathetic release of VIP in the ovine submandibular gland.

Basenji-greyhound dog: increased m2 muscarinic receptor expression in trachealis muscle

1995 ◽  
Vol 268 (6) ◽  
pp. L935-L940 ◽  
Author(s):  
C. W. Emala ◽  
A. Aryana ◽  
M. A. Levine ◽  
R. P. Yasuda ◽  
S. A. Satkus ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Adenylyl Cyclase ◽  
Muscarinic Receptor ◽  
Airway Smooth Muscle ◽  
Muscle Relaxation ◽  
Receptor Expression ◽  
Smooth Muscle Relaxation ◽  
Muscarinic Agonists ◽  
M2 Muscarinic Receptor ◽  
Muscarinic M2 Receptors

Airway smooth muscle from asthmatic humans and from the Basenji-greyhound dog (BG) dog is hyporesponsive to beta-adrenergic agonist stimulation. Because adenylyl cyclase is under dual regulation in airway smooth muscle, we compared muscarinic receptor-coupled inhibition of adenylyl cyclase in airway smooth muscle from BG and mongrel dogs. Inhibition of forskolin-stimulated adenylyl cyclase activity by the muscarinic M2 agonist oxotremorine was greater in airway smooth muscle membranes from BG compared with mongrel controls. Quantitative immunoprecipitation studies showed increased numbers of m2 but not m3 muscarinic receptors in the BG airway smooth muscle. The enhanced ability of muscarinic agonists to inhibit adenylyl cyclase in BG airway smooth muscle may be due to the greater numbers of muscarinic m2 receptors, which may account in part for impaired airway smooth muscle relaxation in the BG model of airway hyperresponsiveness.

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