The M2/M4 Muscarinic Receptor Agonist BuTAC Attenuates Dopamine-Agonist Induced Behaviors

2003 ◽  
Author(s):  
Mary Clare Kane ◽  
Dave Wirtshafter
Keyword(s):  
Dopamine Agonist ◽  
Muscarinic Receptor ◽  
Receptor Agonist ◽  
M4 Muscarinic Receptor

Differences between rat dorsal and ventral hippocampus in muscarinic receptor agonist binding and interaction with phospholipase C

1993 ◽  
Vol 244 (2) ◽  
pp. 125-131 ◽  
Author(s):  
Antonio J. Garcia Ruiz ◽  
Matilde Zambelli ◽  
Caterina La Porta ◽  
Herbert Ladinsky ◽  
Silvana Consolo
Keyword(s):  
Phospholipase C ◽  
Muscarinic Receptor ◽  
Receptor Agonist ◽  
Ventral Hippocampus ◽  
Agonist Binding

Effects of MeCh, thapsigargin, and La3+ on plasmalemmal and intracellular Ca2+ transport in lacrimal acinar cells

1990 ◽  
Vol 258 (6) ◽  
pp. C1006-C1015 ◽  
Author(s):  
C. Y. Kwan ◽  
H. Takemura ◽  
J. F. Obie ◽  
O. Thastrup ◽  
J. W. Putney
Keyword(s):  
Plasma Membrane ◽  
Muscarinic Receptor ◽  
Extracellular Space ◽  
Receptor Agonist ◽  
Inositol Phosphates ◽  
Acinar Cells ◽  
Direct Channel ◽  
Physiological Conditions ◽  
Parotid Cells ◽  
Lacrimal Acinar Cells

The Ca2(+)-mobilizing actions of the muscarinic receptor agonist, methacholine (MeCh), and the microsomal Ca2+ pump inhibitor, thapsigargin, were investigated in lacrimal acinar cells. As previously shown for parotid cells (J. Biol. Chem. 264: 12266-12271, 1989), thapsigargin activates both internal Ca2+ release and Ca2+ entry from the extracellular space without increasing cellular inositol phosphates. The inorganic Ca2+ antagonist La3+ inhibited MeCh- or thapsigargin-activated Ca2+ entry. However, when added before MeCh or thapsigargin, La3+ inhibited the extrusion of Ca2+ at the plasma membrane. This phenomenon was exploited in protocols designed to investigate the pathways for filling agonist-sensitive Ca2+ stores in lacrimal cells. The results show that, in contrast to previous suggestions that external Ca2+ is required to replenish agonist-regulated Ca2+ stores, the inhibition of Ca2+ extrusion permits recycling of Ca2+ released by MeCh back into an MeCh- and thapsigargin-sensitive pool. Thus, although extracellular Ca2+ is the major source for refilling the intracellular Ca2+ stores under physiological conditions, the pathway by which this Ca2+ enters the pool need not be a direct one. These results are consistent with the recently revised capacitative model for the refilling of intracellular Ca2+ stores through Ca2+ influx subsequent to Ca2+ depletion, according to which refilling of intracellular Ca2+ stores occurs via a cytoplasmic route rather than a direct channel between intracellular Ca2+ stores and the extracellular space.

Altered distribution of M2 and M4 muscarinic receptor expression in vitiligo

2010 ◽  
Vol 38 (5) ◽  
pp. 493-497
Author(s):  
Sirintip CHAICHALOTORNKUL ◽  
Montree UDOMPATAIKUL ◽  
Udomsri SHOWPITTAPORNCHAI ◽  
Piti PALUNGWACHIRA ◽  
Wisuit PRADIDARCHEEP
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Expression ◽  
M4 Muscarinic Receptor

Development of a Radioligand, [3H]LY2119620, to Probe the Human M2 and M4 Muscarinic Receptor Allosteric Binding Sites

2014 ◽  
Vol 86 (1) ◽  
pp. 116-123 ◽  
Author(s):  
Douglas A. Schober ◽  
Carrie H. Croy ◽  
Hongling Xiao ◽  
Arthur Christopoulos ◽  
Christian C. Felder
Keyword(s):  
Muscarinic Receptor ◽  
Binding Sites ◽  
Allosteric Binding Sites ◽  
M4 Muscarinic Receptor

Pharmacological Characterization of PD151832, an M1 Muscarinic Receptor Agonist

1997 ◽  
pp. 311-315
Author(s):  
Roy D. Schwarz ◽  
Michael J. Callahan ◽  
Robert E. Davis ◽  
Mark R. Emmerling ◽  
Juan C. Jaen ◽  
...  
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Agonist ◽  
Pharmacological Characterization ◽  
M1 Muscarinic

The contribution of muscarinic-receptor-mediated responses to epineurial vascular diameter at the sciatic nerve

2018 ◽  
Vol 96 (8) ◽  
pp. 855-858
Author(s):  
Chelsa Killey ◽  
Shane Cleary ◽  
Julie Orr ◽  
Jefferson C. Frisbee ◽  
Dwayne Jackson ◽  
...  
Keyword(s):  
Mean Arterial Pressure ◽  
Sciatic Nerve ◽  
Arterial Pressure ◽  
Muscarinic Receptor ◽  
Topical Application ◽  
Rat Model ◽  
Receptor Agonist ◽  
Vessel Diameter ◽  
Anaesthetized Rat ◽  
Baseline Diameter

This study used an anaesthetized rat model to directly observe changes in diameter of the vessels supplying the sciatic nerve in response to acetylcholine (10−4 M), a muscarinic receptor agonist, and atropine (10−5 M), a muscarinic receptor antagonist. Topical application of acetylcholine resulted in increases in vessel diameter (baseline: 22.0 ± 2.5 μm, acetylcholine: 28.8 ± 3.3 μm), while topical application of atropine resulted in a decrease in diameter (baseline: 26.6 ± 3.2 μm, atropine: 15.5 ± 3.6 μm) of the epineurial vessels. Mean arterial pressure was not affected by either acetylcholine (baseline: 103.8 ± 1.8 mm Hg, acetylcholine: 102.8 ± 3.2 mm Hg) or atropine (baseline: 104.0 ± 1.9 mm Hg, atropine: 105.2 ± 2.2 mm Hg). These data suggest that muscarinic-receptor-mediated responses can affect the diameter of the epineurial vessels at the sciatic nerve. In addition, muscarinic-receptor-mediated responses appear to contribute to baseline diameter of epineurial vessels at the sciatic nerve.

scholarly journals Effects of a novel muscarinic receptor agonist, AF102B, on sympatho- $$$adrenomedullary function in rats

1992 ◽  
Vol 58 ◽  
pp. 170
Author(s):  
Hiroko Togashi ◽  
Yasuko Saito ◽  
Mitsuhiro Yoshioka ◽  
Machiko Matsumoto ◽  
Hideya Saito
Keyword(s):  
Muscarinic Receptor ◽  
Receptor Agonist
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