scholarly journals Infection of Different Cell Lines of Neural Origin with Subacute Sclerosing Panencephalitis (SSPE) Virus

2004 ◽  
Vol 48 (4) ◽  
pp. 277-287 ◽  
Author(s):  
Hiroshi Ishida ◽  
Minoru Ayata ◽  
Masashi Shingai ◽  
Isamu Matsunaga ◽  
Yoshiyuki Seto ◽  
...  
Keyword(s):  
Cell Lines ◽  
Subacute Sclerosing Panencephalitis ◽  
Sspe Virus ◽  
Neural Origin

Use of Protein a Conjugated to Peroxidase to Localize Immunoglobulin G in SSPE Ferret Brain

1982 ◽  
Vol 40 ◽  
pp. 350-351
Author(s):  
Hannah R. Brown ◽  
Anthony F. Nostro ◽  
Halldor Thormar
Keyword(s):  
Immunoglobulin G ◽  
Human Disease ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Protein A ◽  
Inflammatory Lesions ◽  
Sspe Virus ◽  
Specific Immunoglobulin ◽  
Antibody Titers ◽  
The Brain

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing disease of the CNS in children which is caused by measles virus. Ferrets immunized with measles virus prior to inoculation with the cell associated, syncytiogenic D.R. strain of SSPE virus exhibit characteristics very similar to the human disease. Measles virus nucleocapsids are present, high measles antibody titers are found in the sera and inflammatory lesions are prominent in the brains. Measles virus specific immunoglobulin G (IgG) is present in the brain,and IgG/ albumin ratios indicate that the antibodies are synthesized within the CNS.

Intravascular Delivery of Neural Stem Cell Lines to Target Intracranial and Extracranial Tumors of Neural and Non-Neural Origin

2003 ◽  
Vol 14 (18) ◽  
pp. 1777-1785 ◽  
Author(s):  
Alice B. Brown ◽  
Wendy Yang ◽  
Nils O. Schmidt ◽  
Rona Carroll ◽  
Kim K. Leishear ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Cell Lines ◽  
Neural Origin ◽  
Stem Cell Lines

scholarly journals DEMONSTRATION OF A BLOCKING FACTOR IN THE PLASMA AND SPINAL FLUID OF PATIENTS WITH SUBACUTE SCLEROSING PANENCEPHALITIS

1974 ◽  
Vol 139 (4) ◽  
pp. 902-924 ◽  
Author(s):  
Aftab Ahmed ◽  
Douglas M. Strong ◽  
Kenneth W. Sell ◽  
Gary B. Thurman ◽  
Richard C. Knudsen ◽  
...  
Keyword(s):  
Subacute Sclerosing Panencephalitis ◽  
Spinal Fluid ◽  
Gel Chromatography ◽  
Immune Responsiveness ◽  
Migration Inhibition ◽  
Virus Infected Cell ◽  
Sspe Virus ◽  
Blocking Factor ◽  
Cell Culture Test ◽  
Macrophage Migration Inhibition

Conflicting reports on the immune responsiveness of patients with subacute sclerosing panencephalitis (SSPE) have been reported. This report shows that the leucocytes from four SSPE patients exhibited strong sensitivity to both measles and SSPE virus preparations as measured by the macrophage migration inhibition test, mixed lymphocyte virus infected cell culture test, and the lymphotoxin assay. Earlier suggestions that a factor may be operating to suppress cellular reactivity are confirmed by the demonstration that the response of lymphocytes from SSPE patients could be blocked by the addition of SSPE spinal fluid or plasma. It was determined that the blocking factor was stable at –20°C, heat labile at 56°C for 30 minutes, trypsin and neuraminadase sensitive, and had a mol wt greater than 150,000 as determined by Sephadex G-200 gel chromatography. The blocking factor appeared to be specific for SSPE virus and did not block the response of lymphocytes to nonspecific mitogenic agents and other viral and bacterial agents.

scholarly journals High-Dose Intravenous Ribavirin Therapy for Subacute Sclerosing Panencephalitis

2001 ◽  
Vol 45 (3) ◽  
pp. 943-945 ◽  
Author(s):  
Mitsuaki Hosoya ◽  
Shiro Shigeta ◽  
Shuichi Mori ◽  
Akemi Tomoda ◽  
Seiji Shiraishi ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Virus Replication ◽  
Subacute Sclerosing Panencephalitis ◽  
Alpha Interferon ◽  
High Dose ◽  
Sspe Virus ◽  
High Doses

ABSTRACT Two patients with subacute sclerosing panencephalitis (SSPE) were treated safely and effectively with high doses of intravenous ribavirin combined with intraventricular alpha interferon. The ribavirin concentrations maintained in the serum and cerebrospinal fluid were higher than those which inhibit SSPE virus replication in vitro and in vivo.

Interferon production by cells infected with subacute sclerosing panencephalitis (SSPE) virus or measles virus

Cytokine ◽  
2011 ◽  
Vol 56 (3) ◽  
pp. 676-679 ◽  
Author(s):  
Shunji Hasegawa ◽  
Natsumi Mori ◽  
Mika Satomi ◽  
Da-Peng Jiang ◽  
Hak Hotta ◽  
...  
Keyword(s):  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Interferon Production ◽  
Sspe Virus
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