Validation of the cantharidin-induced skin blister as anin vivomodel of inflammation

ABSTRACT The pharmacokinetic disposition of meropenem, administered at 500 mg every 8 h, in plasma and cantharidin-induced blister fluid is described. Peak meropenem concentrations in blister fluid lagged behind peak meropenem concentrations in plasma, while a lower elimination rate from blister fluid was also noted. The mean penetration of meropenem into blister fluid was 67%. The pharmacokinetic profile of meropenem in blister fluid supports the utility of this dose in the management of skin and soft tissue infections.

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Pharmacokinetics and Pharmacodynamics of Levofloxacin against Streptococcus pneumoniae and Staphylococcus aureus in Human Skin Blister Fluid

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.44.5.1352-1355.2000 ◽

2000 ◽

Vol 44 (5) ◽

pp. 1352-1355 ◽

Cited By ~ 22

Author(s):

Andrej Trampuz ◽

Markus Wenk ◽

Zarko Rajacic ◽

Werner Zimmerli

Keyword(s):

Staphylococcus Aureus ◽

Streptococcus Pneumoniae ◽

Oral Dose ◽

Human Skin ◽

Bactericidal Activity ◽

Ex Vivo ◽

Blister Fluid ◽

Pharmacokinetics And Pharmacodynamics ◽

Skin Blister ◽

And Staphylococcus Aureus

ABSTRACT The pharmacokinetics of levofloxacin in serum and in skin blister fluid (SBF) was determined for 20 volunteers after a single 500-mg oral dose of levofloxacin. In addition, ex vivo bactericidal activity of SBF against Streptococcus pneumoniae and Staphylococcus aureus was studied. SBF containing levofloxacin and granulocytes killed 5.2 log of Streptococcus pneumoniae bacteria and 2.0 log of Staphylococcus aureus bacteria during a 6-h incubation.

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Kallikrein Activity in Skin Blister Fluid from Allergen-induced Dual Skin Reactions

New Trends in Allergy ◽

10.1007/978-3-642-67807-3_13 ◽

1981 ◽

pp. 95-96

Author(s):

W. Dorsch ◽

R. Geiger

Keyword(s):

Blister Fluid ◽

Skin Reactions ◽

Skin Blister ◽

Kallikrein Activity

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A 10-year-old boy presented with recurrent episodes of diarrhea, low grade, irregular fever and severe wasting

Bangabandhu Sheikh Mujib Medical University Journal ◽

10.3329/bsmmuj.v12i1.39928 ◽

2019 ◽

Vol 12 (1) ◽

pp. 32-38

Author(s):

Hazera Akter ◽

Md. Wahiduzzaman Mazumder ◽

A. S. M. Bazlul Karim ◽

Subarna Rani Das ◽

Saidul Islam Sumon

Keyword(s):

Weight Loss ◽

Watery Diarrhea ◽

Low Grade ◽

Skin Blister ◽

Repeated Attack

This article has no abstract. The first 100 words appear below: A 10-year old boy, the only issue of his deceased parents, was admitted to the department for the management of recurrent episodes of diarrhea and severe wasting for 2.5 months, low grade, irregular fever with evening rise of temperature, anorexia and repeated attack of skin blister for the last 1 year. The patient complained of chronic, painless, non-bloody, profuse watery diarrhea with a weight loss of 10 kg (decrease to 18 kg from 28 kg prior to illness). He also complained of cough for the last seven days. His father was a driver and died at his 1 year of age due to an unknown disease.

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