Study clinical and subclinical features of Henoch-Schönlein purpura in children
Objective: Describe clinical and subclinical characteristics of Henoch-Schönlein purpura in children. Find the relationship between kidney lesion and clinical and subclinical manifestations. Methods: Cross-sectional descriptive study, including 51 children <15 years of age diagnosed with Schonlein-Henoch purpura being treated at Hue Central Hospital and Hue University Hospital from April 2016 - May 2018. Results: 51 children entered the study: Male:Female =1.3:1; mean age 7.5 3.4 years. At onset, purpura was present in all cases, gastrointestinal manifestations in 66.7%, arthritis/arthralgias in 54.9%, , renal lesion in 19.6%. The most frequent laboratory abnormalities were Leukocytosis (WBC >10 x 109/L) in 60,8%, high-erythrocyte sedimentation rate (ESR) in 80.4%, microscopic hematuria in 15.7%, proteinuria in 13.7%. Renal lesion were correlated with age of onset. The age group> 10 years old has 6.1 times more kidney lesion than the group ≤ 10 years (OR: 6.1; 95% CI (1.5-26). Conclusion: Clinical and subclinical findings of Schonlein-Henoch purpura in our study are similar to those in the literature. There is an relationship between the age of onset with kidney lesion.
Key words: Henoch-Schönlein purpura, kidney lesion
Nghiên cứu đặc điểm lâm sàng và cận lâm sàng bệnh schonlein-henoch ở trẻ em