Serial liver biopsies in psoriatic patients receiving long-term etretinate

1985 ◽  
Vol 112 (1) ◽  
pp. 77-81 ◽  
Author(s):  
H.H. ROENIGK ◽  
C. GIBSTINE ◽  
S. GLAZER ◽  
M. SPARBERG ◽  
H. YOKOO
Keyword(s):  
Liver Biopsies

Sequential liver biopsies during long-term methotrexate treatment for psoriasis: a reappraisal

2006 ◽  
Vol 133 (5) ◽  
pp. 774-778 ◽  
Author(s):  
M. J. BOFFA ◽  
R.J.G. CHALMERS ◽  
N.Y. HABOUBI ◽  
M. SHOMAF ◽  
D.M. MITCHELL
Keyword(s):  
Liver Biopsies ◽  
Methotrexate Treatment

Hypereosinophilic syndrome associated with sepsis due to Paecilomyces fungi disseminated into the liver

2016 ◽  
Vol 94 (2) ◽  
pp. 149-152
Author(s):  
Vasily M. Akhunov ◽  
A. M. Akhunova ◽  
T. P. Lavrent’eva
Keyword(s):  
Eosinophil Count ◽  
Histological Study ◽  
Hypereosinophilic Syndrome ◽  
Paecilomyces Variotii ◽  
Blood Samples ◽  
Normal Value ◽  
Clinical Recovery ◽  
Liver Biopsies

A 49 year old woman with signs of chronic sepsis, hepatomegaly, and high eosinophil count was under long-term examination including consultations with an oncologist, parasitologist, and hematologist, diagnostic laparotomy, and studies of liver biopsies. Seeding blood samples onto Saburo’s medium resulted in the growth of Paecilomyces variotii Bainier colonies. Counting mature spherules of the fungus revealed 59000 spherules per 1 mcl compared with the normal value of 1000-6000 which suggested paecilomycotic etiology of sepsis. The histological study of liver biopsies demonstrated hemorrhagic foci and eosinophilic infiltrates around fungal spherules. The clinical recovery of the patient was achieved after 3 courses of pulsed terbinafine therapy (500 mg/d every other day for 14 days during a month) in combination with vitamins and i/v infusion of 100 ml of a fluconazole solution (2 mg/ml) every third day (10 procedures during a course of therapy).

Surgical and Medical Treatment of Pyloric and Duodenal Pythiosis in a Dog

2015 ◽  
Vol 51 (6) ◽  
pp. 385-391 ◽  
Author(s):  
David Lee Dycus ◽  
Cory Fisher ◽  
Ryan Butler
Keyword(s):  
Medical Treatment ◽  
Hepatic Cirrhosis ◽  
Response To Treatment ◽  
Billroth Ii ◽  
Partial Pancreatectomy ◽  
Persistent Vomiting ◽  
Initial Surgery ◽  
Mixed Breed ◽  
Liver Biopsies

A 5 yr old, male, neutered mixed-breed dog was referred for persistent vomiting 2 wk following a pyloric biopsy for a pyloric outflow obstruction. Histopathology at the time of initial surgery was suggestive of pythiosis. Following referral, the dog underwent radical surgical treatment with a Billroth II procedure, partial pancreatectomy, and cholecystoduodenostomy. Histopathology and serology confirmed the diagnosis of pythiosis and medical treatment consisting of itraconazole and terbinafine was started postoperatively. Serology titers were checked again at 8, 12, and 24 wk postoperatively revealing a positive response to treatment and no reoccurrence of pythiosis. Since surgery, the patient experienced waxing and waning elevations of liver values and laparoscopic liver biopsies 10 mo postoperatively revealed hepatic cirrhosis with fibrosis, bile duct hyperplasia, and chronic inflammation. This report documents successful treatment of pyloric/duodenal pythiosis and the long-term (17 mo) consequences associated with the Billroth II, partial pancreatectomy, and biliary rerouting in the dog.

scholarly journals Long-term persistence of Coxiella burnetii in the host after primary Q fever

2000 ◽  
Vol 124 (3) ◽  
pp. 543-549 ◽  
Author(s):  
R. J. HARRIS ◽  
P. A. STORM ◽  
A. LLOYD ◽  
M. ARENS ◽  
B. P. MARMION
Keyword(s):  
Bone Marrow ◽  
Coxiella Burnetii ◽  
Primary Infection ◽  
Mononuclear Cells ◽  
Q Fever ◽  
Fatigue Syndrome ◽  
Products Of Conception ◽  
Liver Biopsies ◽  
Acute Q Fever

After a primary infection Coxiella burnetii may persist covertly in animals and recrudesce at parturition to be shed in the products of conception and the milk. Similar latent persistence and recrudescence occurs in man: namely, infection of placenta, heart valve or mural endocardium, bone or liver. The numbers of organisms, their viability and cellular form, and the underlying organ sites of latent infection for the coxiella are obscure. During investigations of 29 patients with a chronic sequel to acute Q fever, the post-Q fever fatigue syndrome (QFS) [1–3], sensitive conventional and TaqMan-based PCR revealed low levels of C. burnetii DNA in blood mononuclear cells (5/29; 17%), thin needle liver biopsies (2/14; 14%) and, notably, in bone marrow aspirates (13/20; 65%). Irrespective of the ultimate significance of coxiella persistence for QFS, the detection of C. burnetii genomic DNA in bone marrow several years after a primary infection unveils a new pathological dimension for Q fever.

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