scholarly journals Retraction: Fatty acid synthase is a novel therapeutic target in multiple myeloma

2008 ◽  
Vol 141 (5) ◽  
pp. 659-671 ◽  
Author(s):  
Yutaka Okawa ◽  
Teru Hideshima ◽  
Hiroshi Ikeda ◽  
Noopur Raje ◽  
Sonia Vallet ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Fatty Acid ◽  
Therapeutic Target ◽  
Fatty Acid Synthase ◽  
Novel Therapeutic

scholarly journals Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells

2010 ◽  
Vol 12 (6) ◽  
Author(s):  
Quanri Jin ◽  
Linda X Yuan ◽  
Delphine Boulbes ◽  
Jong Min Baek ◽  
Ying Nai Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Cancer Cells ◽  
Therapeutic Target ◽  
Breast Cancer Cells ◽  
Fatty Acid Synthase ◽  
Novel Therapeutic

scholarly journals Histone deacetylase 3 as a novel therapeutic target in multiple myeloma

Leukemia ◽  
2013 ◽  
Vol 28 (3) ◽  
pp. 680-689 ◽  
Author(s):  
J Minami ◽  
R Suzuki ◽  
R Mazitschek ◽  
G Gorgun ◽  
B Ghosh ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Histone Deacetylase ◽  
Therapeutic Target ◽  
Histone Deacetylase 3 ◽  
Novel Therapeutic

scholarly journals Lipidomic profiling reveals soluble epoxide hydrolase as a therapeutic target of obesity-induced colonic inflammation

2018 ◽  
Vol 115 (20) ◽  
pp. 5283-5288 ◽  
Author(s):  
Weicang Wang ◽  
Jun Yang ◽  
Jianan Zhang ◽  
Yuxin Wang ◽  
Sung Hee Hwang ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Therapeutic Target ◽  
Epoxide Hydrolase ◽  
Soluble Epoxide Hydrolase ◽  
Colon Tissue ◽  
Colonic Inflammation ◽  
Obesity Epidemic ◽  
Genetic Ablation ◽  
Endogenous Lipid ◽  
Novel Therapeutic

Obesity is associated with enhanced colonic inflammation, which is a major risk factor for colorectal cancer. Considering the obesity epidemic in Western countries, it is important to identify novel therapeutic targets for obesity-induced colonic inflammation, to develop targeted strategies for prevention. Eicosanoids are endogenous lipid signaling molecules involved in regulating inflammation and immune responses. Using an LC-MS/MS–based lipidomics approach, we find that obesity-induced colonic inflammation is associated with increased expression of soluble epoxide hydrolase (sEH) and its eicosanoid metabolites, termed fatty acid diols, in colon tissue. Furthermore, we find that pharmacological inhibition or genetic ablation of sEH reduces colonic concentrations of fatty acid diols, attenuates obesity-induced colonic inflammation, and decreases obesity-induced activation of Wnt signaling in mice. Together, these results support that sEH could be a novel therapeutic target for obesity-induced colonic inflammation and associated diseases.

A HGF/cMET Autocrine Loop Is Operative in Multiple Myeloma Bone Marrow Endothelial Cells and May Represent a Novel Therapeutic Target

2014 ◽  
Vol 20 (22) ◽  
pp. 5796-5807 ◽  
Author(s):  
Arianna Ferrucci ◽  
Michele Moschetta ◽  
Maria Antonia Frassanito ◽  
Simona Berardi ◽  
Ivana Catacchio ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Endothelial Cells ◽  
Therapeutic Target ◽  
Autocrine Loop ◽  
Novel Therapeutic
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