PLASMA LEVELS OF NORETHINDRONE AFTER SINGLE ORAL DOSE ADMINISTRATION OF NORETHINDRONE AND LYNESTRENOL

1979 ◽  
Vol 10 (1) ◽  
pp. 29-38 ◽  
Author(s):  
V. ODLIND ◽  
E. WEINER ◽  
A. VICTOR ◽  
E. D. B. JOHANSSON
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Plasma Levels ◽  
Dose Administration

Plasma levels of m-chlorophenylpiperazine following single oral dose administration of m-chlorophenylpiperazine and trazodone in human volunteers

1997 ◽  
Vol 41 (6) ◽  
pp. 756-757 ◽  
Author(s):  
Brian A. Lawlor ◽  
Jeanne Radcliffe ◽  
Rick Martinez ◽  
Trey Sunderland ◽  
Dennis L. Murphy
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Plasma Levels ◽  
Dose Administration ◽  
Human Volunteers

Influence of body condition on plasma prednisolone and prednisone concentrations in clinically healthy cats after single oral dose administration

2013 ◽  
Vol 95 (1) ◽  
pp. 225-230 ◽  
Author(s):  
Sharon A. Center ◽  
John F. Randolph ◽  
Karen L. Warner ◽  
Kenneth W. Simpson ◽  
Mark Rishniw
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Body Condition ◽  
Dose Administration

BIOLOGICAL HALF-LIFE OF CAFFEINE IN PIGS

1970 ◽  
Vol 50 (1) ◽  
pp. 49-54 ◽  
Author(s):  
H. M. CUNNINGHAM
Keyword(s):  
Oral Dose ◽  
Water Content ◽  
Single Oral Dose ◽  
Plasma Levels ◽  
Half Life ◽  
Intramuscular Injection ◽  
Peak Plasma ◽  
Growing Pigs ◽  
Sufficient Time ◽  
Biological Half Life

Five experiments were conducted with growing pigs to determine the biological half-life of caffeine after injection or various periods of ingestion. Peak plasma caffeine levels were reached within 5 hr after a single oral dose and 2 hr after intramuscular injection, and then declined with a biological half-life of about 12 hr. The caffeine content of tissues was approximately proportional to their water content and 6% of orally administered caffeine was excreted in the urine. Upon continuous ingestion of caffeine, peak plasma levels were reached within 2 days, indicating that accumulation was quite limited. When 1.5 g of caffeine per kg of feed was fed from weaning to market weight, the withdrawal of caffeine 2 days prior to slaughter was sufficient time to insure that caffeine levels in the liver, muscle, kidney and backfat were below 1 μg/g.

Inhibitory effect of cyproheptadine on ACTH secretion in patients with Addison's disease

1983 ◽  
Vol 102 (1) ◽  
pp. 111-115
Author(s):  
P. Loli ◽  
F. Frascatani ◽  
D. Gelli ◽  
M. Maggioni ◽  
F. Muratori ◽  
...  
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Drug Administration ◽  
Plasma Levels ◽  
Addison’S Disease ◽  
Inhibitory Effect ◽  
Feedback Mechanism ◽  
Addison's Disease ◽  
Acth Secretion ◽  
Acth Release

Abstract. In 14 patients with Addison's disease plasma levels of ACTH were studied after administration of a single oral dose (16 mg) of cyproheptadine. The drug administration was followed by an inhibition of ACTH release. These results support the view that cyproheptadine may exert an inhibitory effect on ACTH secretion in subjects whose corticosteroid feedback mechanism is normal. We hypothesize that the effect of cyproheptadine might be related to its anti-serotonin or anti-histaminergic action.

Sign in / Sign up

Export Citation Format

Share Document