CIRCULATING BIOACTIVE FOLLICLE STIMULATING HORMONE AND IMMUNOREACTIVE INHIBIN LEVELS DURING THE NORMAL HUMAN MENSTRUAL CYCLE

1990 ◽  
Vol 33 (4) ◽  
pp. 547-557 ◽  
Author(s):  
K. REDDI ◽  
E. J. WICKINGS ◽  
A. S. McNEILLY ◽  
D. T. BAIRD ◽  
S. G. HILLIER
Keyword(s):  
Menstrual Cycle ◽  
Follicle Stimulating Hormone ◽  
Normal Human ◽  
Human Menstrual Cycle ◽  
Stimulating Hormone

CHANGES IN THE BINDING OF HUMAN CHORIONIC GONADOTROPHIN/LUTEINIZING HORMONE, FOLLICLE-STIMULATING HORMONE AND PROLACTIN TO HUMAN CORPORA LUTEA DURING THE MENSTRUAL CYCLE AND PREGNANCY

1980 ◽  
Vol 87 (3) ◽  
pp. 315-325 ◽  
Author(s):  
A. S. McNEILLY ◽  
J. KERIN ◽  
I. A. SWANSTON ◽  
T. A. BRAMLEY ◽  
D. T. BAIRD
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Luteal Phase ◽  
Follicle Stimulating Hormone ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Corpora Lutea ◽  
Maximum Serum ◽  
Human Menstrual Cycle ◽  
Stimulating Hormone

The changes in the binding of human chorionic gonadotrophin/luteinizing hormone (HCG/LH), follicle-stimulating hormone (FSH) and prolactin to 44 corpora lutea have been assessed during the luteal phase of the human menstrual cycle and early pregnancy. All corpora lutea bound HCG but out of 32 only ten bound FSH and only seven bound prolactin specifically. While binding of HCG increased to maximal levels in the mid-luteal phase, binding of FSH and prolactin was most often found in the early luteal phase. Maximum binding of HCG was associated with maximum serum levels of progesterone. Luteal regression was associated with a decrease in the binding of HCG but a causal relationship could not be established. Very low binding of HCG was found to corpora lutea of pregnancy. These results show that (1) the changes in binding of HCG during the luteal phase of the human menstrual cycle are similar to those in other species and (2) there are specific binding sites for prolactin and FSH in the human corpus luteum.

Emergent Oscillations in Mathematical Model of the Human Menstrual Cycle

CNS Spectrums ◽  
2003 ◽  
Vol 8 (11) ◽  
pp. 805-814 ◽  
Author(s):  
Natalie L. Rasgon ◽  
Lara Pumphrey ◽  
Paolo Prolo ◽  
Shana Elman ◽  
Andre B. Negrao ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Oscillatory Behavior ◽  
Follicular Phase ◽  
Gonadal Steroids ◽  
Early Follicular Phase ◽  
Human Menstrual Cycle ◽  
Stimulating Hormone

ABSTRACTBackground:The aim of this study was to develop a mathematical model of the hypothalamo-pituitary-gonadal axis that would reflect available data in humans.Methods:A model of hormonal relationships at the early follicular and midluteal phases of the human menstrual cycle is proposed.Findings:Two distinct temporal patterns of oscillatory behavior have been demonstrated for both pituitary and gonadal steroids in the early follicular phase: first, rapid oscillations in gonadotropin releasing hormone, follicle stimulating hormone, and luteinizing hormone (Q∼1 hour) that were an immediate consequence of the programmed equations. Second, there were slower, undulating, emergent rhythms in luteinizing hormone and follicle stimulating hormone, and also in estrogen, having oscillatory periods of 2–12 hours. There was also a longer-period (Q2–3 days) emergent rhythm in progesterone. In the mid-luteal phase, estrogen and progesterone rhythms were correlated, and all hormones showed an ∼6-hour periodicity.Conclusion:To our knowledge, the oscillatory behavior of peripheral sex steroids in the follicular phase has not been previously noted.

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