Homologous in vitro bioassay for follicle-stimulating hormone (FSH) reveals increased FSH biological signal during the mid- to late luteal phase of the human menstrual cycle

1996 ◽  
Vol 81 (6) ◽  
pp. 2080-2088 ◽  
Author(s):  
S. Christin-Maitre
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Follicle Stimulating Hormone ◽  
In Vitro Bioassay ◽  
Biological Signal ◽  
Late Luteal Phase ◽  
Human Menstrual Cycle ◽  
Stimulating Hormone

CHANGES IN THE BINDING OF HUMAN CHORIONIC GONADOTROPHIN/LUTEINIZING HORMONE, FOLLICLE-STIMULATING HORMONE AND PROLACTIN TO HUMAN CORPORA LUTEA DURING THE MENSTRUAL CYCLE AND PREGNANCY

1980 ◽  
Vol 87 (3) ◽  
pp. 315-325 ◽  
Author(s):  
A. S. McNEILLY ◽  
J. KERIN ◽  
I. A. SWANSTON ◽  
T. A. BRAMLEY ◽  
D. T. BAIRD
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Luteal Phase ◽  
Follicle Stimulating Hormone ◽  
Chorionic Gonadotrophin ◽  
Human Chorionic Gonadotrophin ◽  
Corpora Lutea ◽  
Maximum Serum ◽  
Human Menstrual Cycle ◽  
Stimulating Hormone

The changes in the binding of human chorionic gonadotrophin/luteinizing hormone (HCG/LH), follicle-stimulating hormone (FSH) and prolactin to 44 corpora lutea have been assessed during the luteal phase of the human menstrual cycle and early pregnancy. All corpora lutea bound HCG but out of 32 only ten bound FSH and only seven bound prolactin specifically. While binding of HCG increased to maximal levels in the mid-luteal phase, binding of FSH and prolactin was most often found in the early luteal phase. Maximum binding of HCG was associated with maximum serum levels of progesterone. Luteal regression was associated with a decrease in the binding of HCG but a causal relationship could not be established. Very low binding of HCG was found to corpora lutea of pregnancy. These results show that (1) the changes in binding of HCG during the luteal phase of the human menstrual cycle are similar to those in other species and (2) there are specific binding sites for prolactin and FSH in the human corpus luteum.

Plasma bradykininogen and reproductive cycles: studies during the oestrous cycle and pregnancy in the rat, and in the human menstrual cycle

1976 ◽  
Vol 54 (6) ◽  
pp. 941-947 ◽  
Author(s):  
M. McDonald ◽  
A. M. Perks
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Oestrous Cycle ◽  
Menstrual Cycles ◽  
Late Luteal Phase ◽  
Human Menstrual Cycle ◽  
Reproductive Cycles ◽  
In Pregnancy

Plasma bradykininogen levels have been shown to rise about threefold late in pregnancy in the rat. However, they declined sharply 1–2 days before delivery.Plasma bradykininogen levels remained relatively unchanged through most the oestrous and menstrual cycles (rat, man). However, they showed a fall at two similar periods, in both cycles. A smaller decline occurred in metoestrus in the rat, and (probably) in the late luteal phase in the human. The largest fall took place around the time of ovulation in both the oestrous and the menstrual cycles. The decline was about 59% in the rat and 42% in the human. Bradykininogen showed no similar changes in the blood of male human controls. The suggestion that bradykinin could be involved in ovulation is discussed.

Normal Menstrual Cycle

2018 ◽  
Author(s):  
Rebecca Pierson ◽  
Kelly Pagidas
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Luteal Phase ◽  
Follicle Stimulating Hormone ◽  
Follicular Phase ◽  
Gonadotropin Releasing Hormone ◽  
Hormonal Control ◽  
Releasing Hormone ◽  
Normal Menstrual Cycle ◽  
Stimulating Hormone

A normal menstrual cycle is the end result of a sequence of purposeful and coordinated events that occur from intact hypothalamic-pituitary-ovarian and uterine axes. The menstrual cycle is under hormonal control in the reproductively active female and is functionally divided into two phases: the proliferative or follicular phase and the secretory or luteal phase. This tight hormonal control is orchestrated by a series of negative and positive endocrine feedback loops that alter the frequency of the pulsatile secretion of gonadotropin-releasing hormone (GnRH), the pituitary response to GnRH, and the relative secretion of luteinizing hormone and follicle-stimulating hormone from the pituitary gonadotrope with subsequent direct effects on the ovary to produce a series of sex steroids and peptides that aid in the generation of a single mature oocyte and the preparation of a receptive endometrium for implantation to ensue. Any derailment along this programmed pathway can lead to an abnormal menstrual cycle with subsequent impact on the ability to conceive and maintain a pregnancy. This review contains 7 figures and 26 references Key words: follicle-stimulating hormone, follicular phase, gonadotropin-releasing hormone, luteal phase, luteinizing hormone, menstrual cycle, ovulation, progesterone, proliferative phase, secretory phase

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