Both Inhibin A and B Respond to Exogenous Follicle-Stimulating Hormone in the Follicular Phase of the Human Menstrual Cycle

1998 ◽  
Vol 83 (11) ◽  
pp. 4167-4169 ◽  
Author(s):  
H. G. Burger
Keyword(s):  
Menstrual Cycle ◽  
Follicle Stimulating Hormone ◽  
Follicular Phase ◽  
Inhibin A ◽  
Human Menstrual Cycle ◽  
Stimulating Hormone

Emergent Oscillations in Mathematical Model of the Human Menstrual Cycle

CNS Spectrums ◽  
2003 ◽  
Vol 8 (11) ◽  
pp. 805-814 ◽  
Author(s):  
Natalie L. Rasgon ◽  
Lara Pumphrey ◽  
Paolo Prolo ◽  
Shana Elman ◽  
Andre B. Negrao ◽  
...  
Keyword(s):  
Mathematical Model ◽  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Follicle Stimulating Hormone ◽  
Oscillatory Behavior ◽  
Follicular Phase ◽  
Gonadal Steroids ◽  
Early Follicular Phase ◽  
Human Menstrual Cycle ◽  
Stimulating Hormone

ABSTRACTBackground:The aim of this study was to develop a mathematical model of the hypothalamo-pituitary-gonadal axis that would reflect available data in humans.Methods:A model of hormonal relationships at the early follicular and midluteal phases of the human menstrual cycle is proposed.Findings:Two distinct temporal patterns of oscillatory behavior have been demonstrated for both pituitary and gonadal steroids in the early follicular phase: first, rapid oscillations in gonadotropin releasing hormone, follicle stimulating hormone, and luteinizing hormone (Q∼1 hour) that were an immediate consequence of the programmed equations. Second, there were slower, undulating, emergent rhythms in luteinizing hormone and follicle stimulating hormone, and also in estrogen, having oscillatory periods of 2–12 hours. There was also a longer-period (Q2–3 days) emergent rhythm in progesterone. In the mid-luteal phase, estrogen and progesterone rhythms were correlated, and all hormones showed an ∼6-hour periodicity.Conclusion:To our knowledge, the oscillatory behavior of peripheral sex steroids in the follicular phase has not been previously noted.

scholarly journals Both Inhibin A and B Respond to Exogenous Follicle-Stimulating Hormone in the Follicular Phase of the Human Menstrual Cycle1

1998 ◽  
Vol 83 (11) ◽  
pp. 4167-4169
Author(s):  
Henry G. Burger ◽  
Nigel P. Groome ◽  
David M. Robertson
Keyword(s):  
Menstrual Cycle ◽  
Follicle Stimulating Hormone ◽  
Follicular Phase ◽  
Serum Estradiol ◽  
Serum Samples ◽  
Control Value ◽  
Highly Correlated ◽  
Human Menstrual Cycle ◽  
Dose Dependent Increase ◽  
Dose Dependent

To ascertain whether changes in the concentrations of the dimeric inhibins A and/or B (INH-A and INH-B) contributed to the previously described dose-dependent increase in immunoreactive inhibin (INH) in response to FSH during the follicular phase of the human menstrual cycle, both dimers were measured by specific two-site assays in stored serum samples from regularly cycling normal volunteers who had received saline as a control (n = 5) or FSH [100 IU (n = 6) or 200 IU (n = 5)] between days 3–5 of the menstrual cycle. Both INH-A and INH-B showed a dose-dependent increase in response to administered FSH; INH-A rose from 13.5 to 35.9 ng/L (P < 0.01), and INH-B rose from 77.8 to 205 ng/L (P < 0.05) at 36 h after 200 IU FSH. Highly significant correlations were observed between INH and each of the specific inhibin dimers (A: r= 0.79, P < 0.001; B: r = 0.76, P < 0.001), and the responses of the two dimers were also highly correlated (r = 0.59, P < 0.001). The response of each inhibin was also highly correlated with the response of serum estradiol (A: r = 0.45, P < 0.001; B: r = 0.40, P< 0.001). When analyzed by ANOVA, the INH response of INH-B was significantly above the control value at 36 h after treatment with both 100 and 200 IU FSH, whereas the response of INH-A was significant only at 200 IU. It is concluded that the concentrations of both dimeric INH-A and INH-B are stimulated by increases in FSH within the physiological range in the follicular phase of the human menstrual cycle and that both contribute to the previously observed rise in INH.

Normal Menstrual Cycle

2018 ◽  
Author(s):  
Rebecca Pierson ◽  
Kelly Pagidas
Keyword(s):  
Menstrual Cycle ◽  
Luteinizing Hormone ◽  
Luteal Phase ◽  
Follicle Stimulating Hormone ◽  
Follicular Phase ◽  
Gonadotropin Releasing Hormone ◽  
Hormonal Control ◽  
Releasing Hormone ◽  
Normal Menstrual Cycle ◽  
Stimulating Hormone

A normal menstrual cycle is the end result of a sequence of purposeful and coordinated events that occur from intact hypothalamic-pituitary-ovarian and uterine axes. The menstrual cycle is under hormonal control in the reproductively active female and is functionally divided into two phases: the proliferative or follicular phase and the secretory or luteal phase. This tight hormonal control is orchestrated by a series of negative and positive endocrine feedback loops that alter the frequency of the pulsatile secretion of gonadotropin-releasing hormone (GnRH), the pituitary response to GnRH, and the relative secretion of luteinizing hormone and follicle-stimulating hormone from the pituitary gonadotrope with subsequent direct effects on the ovary to produce a series of sex steroids and peptides that aid in the generation of a single mature oocyte and the preparation of a receptive endometrium for implantation to ensue. Any derailment along this programmed pathway can lead to an abnormal menstrual cycle with subsequent impact on the ability to conceive and maintain a pregnancy. This review contains 7 figures and 26 references Key words: follicle-stimulating hormone, follicular phase, gonadotropin-releasing hormone, luteal phase, luteinizing hormone, menstrual cycle, ovulation, progesterone, proliferative phase, secretory phase

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