Impact of intravenous drug use on quality of life for patients with venous ulcers

2007 ◽  
Vol 58 (5) ◽  
pp. 458-467 ◽  
Author(s):  
Simon J. Palfreyman ◽  
Angela M. Tod ◽  
Brenda King ◽  
Darlene Tomlinson ◽  
John E. Brazier ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Drug Use ◽  
Intravenous Drug ◽  
Intravenous Drug Use ◽  
Venous Ulcers

scholarly journals 257. Staphylococcus aureus Bacteremia: Does Intravenous Drug Use Impact Quality of Care and Clinical Outcomes?

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S127-S128
Author(s):  
Kristen McClellan ◽  
Cami Hilsendager ◽  
Strnad Luke
Keyword(s):  
Staphylococcus Aureus ◽  
Quality Of Care ◽  
Drug Use ◽  
Clinical Outcomes ◽  
Intravenous Drug ◽  
Standards Of Care ◽  
Intravenous Drug Use ◽  
Staphylococcus Aureus Bacteremia ◽  
Device Infection

Abstract Background Individuals with intravenous drug use (IDU) have higher risk for Staphylococcus aureus bacteremia (SAB) and increased management complexity. The goal of this study was to compare differences in SAB characteristics, adherence to standard of care metrics, and clinical outcomes in those with and without IDU. Methods A retrospective chart review was conducted on cases of SAB between January 1, 2016 and December 31, 2017 at a 500-bed teaching hospital. Inclusion criteria was age > 18 years and ≥ one blood culture positive for S. aureus. Patients were excluded if they transferred hospitals, had care withdrawn or died within 48 hours of diagnosis or had a ventricular assist device infection. Records were reviewed for substance use, SAB characteristics, standards of care, and outcomes. Data were analyzed using SPSS software. The study was approved by the Institutional Review Board. Results In 248 patients with SAB, 28.2% had documented IDU. Median age was 37 (IDU) and 57 (non-IDU). In the IDU group, 75.7% had the formal diagnosis of opioid use disorder and 78.9% of stimulant use disorder. IDU was associated with hepatitis C and houselessness while non-IDU was associated with diabetes, hemodialysis, and cancer. Those with IDU had higher rates of MRSA, endocarditis, and spinal infections, but did not have higher rates of polymicrobial infections or venous thrombosis. There was no difference in appropriate repeat blood cultures, antibiotic management, and ID consultation. Length of stay and against medical advice (AMA) discharges were higher in those with IDU. There was no difference in 90-day recurrence or readmission, but 90-day mortality was higher in the non-IDU group. Conclusion There was no difference in adherence to SAB quality of care metrics between groups with and without IDU. Despite the IDU group being younger with fewer comorbidities, 90-day readmissions were not different between groups. This bears further analysis but may represent the influence of therapy completion, AMA discharges, and unmeasured social determinants of health. Disclosures All Authors: No reported disclosures

Lack of influence of active intravenous drug use on the management quality of patients with chronic hepatitis C

2003 ◽  
Vol 38 ◽  
pp. 134
Author(s):  
M. Cournot ◽  
F. Castel ◽  
F. Druart ◽  
T. Morin ◽  
V. Lauwers-Cances ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C ◽  
Drug Use ◽  
Chronic Hepatitis C ◽  
Intravenous Drug ◽  
Intravenous Drug Use ◽  
Management Quality

Review of HIV Infection and Intravenous Drug Use.

1993 ◽  
Vol 38 (6) ◽  
pp. 655-656
Author(s):  
Terri Gullickson
Keyword(s):  
Drug Use ◽  
Hiv Infection ◽  
Intravenous Drug ◽  
Intravenous Drug Use

scholarly journals 191. oral versus Intravenous Antibiotic Treatment in Skin and Soft Tissue Infections as a Consequence of Intravenous Drug Use: A Retrospective Study to Demonstrate Noninferiority

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S224-S224
Author(s):  
Aryn M Andrzejewski ◽  
J Alex Viehman
Keyword(s):  
Soft Tissue ◽  
Drug Use ◽  
Length Of Stay ◽  
Oral Therapy ◽  
Statistical Difference ◽  
Treatment Completion ◽  
Intravenous Drug ◽  
Soft Tissue Infections ◽  
Intravenous Drug Use ◽  
Oral Group

Abstract Background Skin and soft tissue infections (SSTIs) are among the most prevalent infectious complications of intravenous drug use (IVDU). Given its polymicrobial nature, studies focusing on SSTIs in the general population may not be generalizable this group. We completed a retrospective chart review to better characterize the safety and efficacy of oral versus intravenous (IV) antibiotics for the treatment SSTIs in IVDU. Methods We reviewed patients admitted with bacterial SSTIs and IVDU from January 01, 2012 to December 31, 2019 based on ICD-10 codes. SSTIs complicated by bacteremia, endocarditis, bone or joint involvement on index admission were excluded. Patients who received < 48 hours of IV antibiotics were considered oral therapy, otherwise they were considered IV therapy. Patient comorbidities, incision and drainage (I&D) status, substance use, microbiology and antimicrobial data were reviewed. Results Of 231 eligible patients, 84 received oral therapy. There was no statistical difference in patient characteristics between the two therapy groups. Streptococcus anginosus group were the most common organisms found (33%) followed by Staphylococcus aureus (31%). There was no statistical difference between rates of readmission (p=0.87), recurrent primary site infection (p=1.00), repeat debridement (p=0.08) or occurrence of deep-seated infections within 90 days of treatment completion. No morality was observed. The oral group had shorter length of stay (3 vs. 5 days, p < 0.001) and shorter total duration of antibiotics (10 vs. 13 days, p < 0.001). Overall, 90% of those with abscess underwent I&D, which did not differ between therapy groups. Time to I&D was shorter (0 vs. 1 day, p=0.005) in the oral group. Patients who did not receive and I&D were more likely to be readmitted within 90 days (p=0.025). Conclusion In SSTIs related to IVDU, oral antibiotic therapy was noninferior to IV in terms of mortality, readmission, and deep-seated infection rates within 90 days of treatment completion and had a decreased length of stay and total treatment duration. A delay in I&D led to increased length of stay and lack of I&D increased readmission rate. Therefore, a prompt I&D may allow a safe and effective early transition to oral therapy in SSTIs related to IVDU. Disclosures All Authors: No reported disclosures

Endocarditis and the impact of intravenous drug use: a cohort study

2021 ◽  
pp. 1-7
Author(s):  
Christopher H. D. Lawrence ◽  
James Cheaveau ◽  
Michalis Kavourides ◽  
David Chadwick ◽  
Brendan McCarron
Keyword(s):  
Cohort Study ◽  
Drug Use ◽  
Intravenous Drug ◽  
Intravenous Drug Use ◽  
The Impact
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