Influence of tegaserod on proximal gastric tone and on the perception of gastric distention in functional dyspepsia

2010 ◽  
Vol 23 (2) ◽  
pp. e32-e39 ◽  
Author(s):  
J. Tack ◽  
P. Janssen ◽  
R. Bisschops ◽  
R. Vos ◽  
T. Phillips ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Tone ◽  
Gastric Distention

scholarly journals Sini-San Regulates the NO-cGMP-PKG Pathway in the Spinal Dorsal Horn in a Modified Rat Model of Functional Dyspepsia

2020 ◽  
Vol 2020 ◽  
pp. 1-11 ◽  
Author(s):  
Zhenyu Wu ◽  
Xiaofang Lu ◽  
Shengsheng Zhang ◽  
Chunyang Zhu
Keyword(s):  
Gene Expression ◽  
Dorsal Horn ◽  
Functional Dyspepsia ◽  
Rat Model ◽  
Spinal Dorsal Horn ◽  
Visceral Hypersensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Gastric Distention ◽  
Real Time Quantitative Pcr ◽  
Spinal Dorsal

The present study investigated the effect of Chinese medicine Sini-San (SNS) on visceral hypersensitivity in a rat model of functional dyspepsia (FD), and it explored related underlying mechanisms. The rat model of FD was developed by combining neonatal iodoacetamide (IA) treatment and adult tail-clamping. After SNS treatment, the behavior and electromyographic testing were performed to evaluate the visceromotor responses of rats to gastric distention. Immunofluorescence was used to detect the distribution of iNOS-positive cells in the spinal dorsal horn, while the real-time quantitative PCR and western blot were used for detection of the gene expression of c-fos, iNOS, and GABAb and protein levels of iNOS and GABAb in the spinal dorsal horn, respectively. The protein concentration of cGMP and PKG proteins in the spinal dorsal horn were quantified by enzyme-linked immunosorbent assay. In this study, SNS treatment significantly reduced the behavioral score and electromyographic response to graded intragastric distension pressure. The middle-dose of SNS treatment significantly reduced the distribution of iNOS-positive cells in the spinal dorsal horn of FD model rats. The gene expression of c-fos, iNOS, and GABAb and the protein contents of iNOS, GABAb, cGMP, and PKG in the spinal dorsal horn of FD model rats were restored to a normal level by middle-dose of SNS treatment. Our results suggest that Sini-San may alleviate the visceral hypersensitivity in FD model rats via regulation of the NO/cGMP/PKG pathway in the spinal dorsal horn.

scholarly journals Gastric Vagal Efferent Inhibition Evoked by Intravenous CRF Is Unrelated to Simultaneously Recorded Vagal Afferent Activity in Urethane-Anesthetized Rats

2007 ◽  
Vol 97 (4) ◽  
pp. 3004-3014 ◽  
Author(s):  
David W. Adelson ◽  
Hovsep P. Kosoyan ◽  
Yuhua Wang ◽  
Justin Z. Steinberg ◽  
Yvette Taché
Keyword(s):  
Impulse Activity ◽  
Simultaneous Recording ◽  
Corticotropin Releasing Factor ◽  
Inhibitory Influence ◽  
Afferent Activity ◽  
Nerve Branch ◽  
Gastric Tone ◽  
Gastric Distention ◽  
Anesthetized Rats ◽  
Vagal Afferent

Corticotropin-releasing factor (CRF) injected peripherally or released in response to stressful challenges to the organism reduces gastric tone and contractility, in part by vagal pathways. However, information on the changes in gastric vagal impulse activity evoked by peripheral CRF administration is entirely lacking. Using a novel “dual recording” method in urethane-anesthetized rats, vagal efferent (VE) and afferent (VA) impulse activities were recorded simultaneously from separate, fine bundles dissected from the ventral gastric vagus nerve branch innervating the glandular stomach. Activity records for 38 VA single units (SUs) and 33 VE SUs were sorted from multiunit records obtained from 13 preparations. Intravenous (iv) administration of saline had no effect on multiunit VE activity, whereas CRF (1 μg/kg, iv) immediately inhibited VE activity, reaching a nadir of 54 ± 8.0% of preinjection levels at 3.0 min postinjection. CRF (1 μg/kg, iv) inhibited 25/33 (75.8%) VE SUs and excited three of 33 (9.1%) VE SUs. In contrast to potent effects on VE activity, iv CRF did not alter multiunit VA activity. Single-unit analysis, however, revealed five of 38 (13.1%) VA SUs excited by iv CRF at widely varying latencies (suggesting an indirect mode of action) and one inhibited VA SU. VA SUs excited after iv CRF did not respond during gastric distention and vice versa. These experiments are the first to use simultaneous recording of gastric VA and VE units. The data demonstrate a predominantly inhibitory influence of iv CRF on VE outflow to the hindstomach, not driven by gastric vagovagal reflex activity.

Influence of itopride and domperidone on gastric tone and on the perception of gastric distention in healthy subjects

2019 ◽  
Vol 31 (4) ◽  
pp. e13544
Author(s):  
Karen Van den Houte ◽  
Florencia Carbone ◽  
Ans Pauwels ◽  
Rita Vos ◽  
Tim Vanuytsel ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Gastric Tone ◽  
Gastric Distention

Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia

2001 ◽  
Vol 121 (3) ◽  
pp. 526-535 ◽  
Author(s):  
Jan Tack ◽  
Philip Caenepeel ◽  
Benjamin Fischler ◽  
Hubert Piessevaux ◽  
Jozef Janssens
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Distention

Fundic tension receptors mediate perception in functional dyspepsia patients with hypersensitivity to gastric distention

2001 ◽  
Vol 120 (5) ◽  
pp. A239-A239
Author(s):  
J TACK ◽  
R VOS ◽  
P CAENEPEEL ◽  
T DEGREEF ◽  
H PIESSEVAUX ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Distention

scholarly journals Effect of acute and chronic levosulpiride administration on gastric tone and perception in functional dyspepsia

2002 ◽  
Vol 16 (3) ◽  
pp. 613-622 ◽  
Author(s):  
E. Distrutti ◽  
S. Fiorucci ◽  
S. K. Hauer ◽  
M. O. Pensi ◽  
M. Vanasia ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Tone

D2-antagonist levosulpiride inhibits afferent mediating perception of gastric distention in functional dyspepsia

2001 ◽  
Vol 120 (5) ◽  
pp. A461
Author(s):  
Eleonora Distrutti ◽  
Maria O. Pensi ◽  
Susanne K. Hauer ◽  
Massimo Vanasia ◽  
Antonio Morelli
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Distention ◽  
D2 Antagonist

D2-antagonist levosulpiride inhibits afferent mediating perception of gastric distention in functional dyspepsia

2001 ◽  
Vol 120 (5) ◽  
pp. A461-A461
Author(s):  
E DISTRUTTI ◽  
M PENSI ◽  
S HAUER ◽  
M VANASIA ◽  
A MORELLI
Keyword(s):  
Functional Dyspepsia ◽  
Gastric Distention ◽  
D2 Antagonist

scholarly journals Examination of Visceral Perception and Gastric Tone by Gastric Stimulation Using Air Inflation during Endoscopy

2005 ◽  
Vol 33 (2) ◽  
pp. 160-169 ◽  
Author(s):  
T Suzuki ◽  
M Hirano ◽  
Y Yamamoto
Keyword(s):  
Functional Dyspepsia ◽  
Pressure Transducer ◽  
Time Pressure ◽  
Pressure Curve ◽  
Intragastric Pressure ◽  
Visceral Perception ◽  
Gastric Stimulation ◽  
Perception Threshold ◽  
Gastric Tone ◽  
Normal Controls

This study investigated the assessment of visceral perception and gastric tone using insufflation during endoscopy. The intragastric pressure was measured during insufflation in 16 patients with gastro-oesophageal reflux disease, 25 patients with functional dyspepsia and 24 normal controls, using a pressure transducer inserted through the forceps aperture until gastric symptoms appeared. The intragastric pressure at the visceral perception threshold, the time to threshold and the time-pressure curve gradient were measured. The visceral perception threshold was significantly reduced in the functional dyspepsia group compared with the normal controls. Balloons were also inserted into the duodenal bulbs of 10 normal controls to investigate the effect of efflux of air into the duodenum; the measured parameters were not influenced by inflation and deflation. These results suggest that it is possible to assess visceral perception and gastric tone by measuring changes in intragastric pressure, using gastric stimulation by insufflation during endoscopy.

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