Comparison of the pathology of cerebral white matter with post-mortem magnetic resonance imaging (MRI) in the elderly brain

2004 ◽  
Vol 30 (4) ◽  
pp. 385-395 ◽  
Author(s):  
M. S. Fernando ◽  
J. T. O'Brien ◽  
R. H. Perry ◽  
P. English ◽  
G. Forster ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
The Elderly ◽  
Cerebral White Matter ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Magnetic Resonance Imaging Mri

Late presentation of NMOSD as rapidly progressive leukoencephalopathy with atypical clinical and radiological findings

2017 ◽  
Vol 24 (5) ◽  
pp. 685-688 ◽  
Author(s):  
Elia Sechi ◽  
Alberto Addis ◽  
Lucia Batzu ◽  
Sara Mariotto ◽  
Sergio Ferrari ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
The Elderly ◽  
Late Presentation ◽  
Neuromyelitis Optica Spectrum Disorder ◽  
Resonance Imaging ◽  
Radiological Findings ◽  
Mri Findings ◽  
Magnetic Resonance Imaging Mri

Brain abnormalities in neuromyelitis optica spectrum disorder (NMOSD) are highly heterogeneous and often non-specific. Extensive white matter involvement has been described and frequently manifests with encephalopathy requiring prompt intervention. Rarely, this may represent the only manifestation at onset without concurrent suggestive features of the disease, thus making diagnosis challenging. NMOSD may potentially occur at any age, but it seems that this disorder has distinctive clinical features in the elderly. We describe a case of NMOSD presenting as rapidly progressive leukoencephalopathy with atypical clinical and magnetic resonance imaging (MRI) findings in a 69-year-old woman.

scholarly journals Post-Mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Progressive Supranuclear Palsy with and without Cerebral Amyloid Angiopathy

NeuroSci ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 115-120
Author(s):  
Jacques De Reuck ◽  
Florent Auger ◽  
Nicolas Durieux ◽  
Claude-Alain Maurage ◽  
Vincent Deramecourt ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Progressive Supranuclear Palsy ◽  
Cerebral Amyloid Angiopathy ◽  
Amyloid Angiopathy ◽  
Post Mortem ◽  
Resonance Imaging ◽  
Cerebral Amyloid ◽  
Magnetic Resonance Imaging Mri ◽  
Neuropathological Examination

Introduction and Purpose: Cerebral amyloid angiopathy (CAA) can be observed in patients with progressive supranuclear palsy (PSP), though to a lesser degree than in Alzheimer’s disease. The present post-mortem 7.0-tesla magnetic resonance imaging (MRI) evaluates whether CAA has an influence on the degree of hippocampal atrophy (HA) and on the incidence of associated micro-infarcts (HMIs) and cortical micro-bleeds (HMBs). Material and Methods: Eight brains with PSP-CAA were compared to 20 PSP brains without CAA. In addition to the neuropathological examination, the hippocampus was evaluated on the most representative coronal section with T2 and T2*-weighted MRI sequences. The average degree of HA was determined in both groups. The incidence of HMIs and HMBs was also compared as well as the frequency of cortical micro-infarcts (CoMIs) and cortical micro-bleeds (CoMBs) in the hemispheric neocortex. Results: The neuropathological examination showed a higher incidence of lacunar infarcts in the PSP-CAA brains compared to the PSP ones. With magnetic resonance imaging (MRI), the severity of HA and the incidence of HMIs and HMBs was similar between both groups. Additionally, the frequency of CoMIs and CoMBs in the neocortex was comparable. Conclusions: The association of CAA in PSP brains has no influence on the degree of HA and on the incidence of the small cerebrovascular lesions in the hippocampus as well as in the neocortex.

scholarly journals Characterization of Cerebral White Matter Properties Using Quantitative Magnetic Resonance Imaging Stains

2011 ◽  
Vol 1 (6) ◽  
pp. 423-446 ◽  
Author(s):  
Andrew L. Alexander ◽  
Samuel A. Hurley ◽  
Alexey A. Samsonov ◽  
Nagesh Adluru ◽  
Ameer Pasha Hosseinbor ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Cerebral White Matter ◽  
Resonance Imaging ◽  
Quantitative Magnetic Resonance Imaging ◽  
Quantitative Magnetic Resonance

Magnetic Resonance Imaging of Metabolic Diseases of the Cerebral White Matter

2009 ◽  
Vol 20 (6) ◽  
pp. 333-341 ◽  
Author(s):  
Maria Isabel Vargas ◽  
Laura Merlini ◽  
Sven Haller ◽  
Victor Cuvinciuc ◽  
Gerhard Schroth ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Metabolic Diseases ◽  
Cerebral White Matter ◽  
Resonance Imaging

Cognitive Functioning and Magnetic Resonance Imaging in Chronic Fatigue

1995 ◽  
Vol 167 (1) ◽  
pp. 86-94 ◽  
Author(s):  
Helen Cope ◽  
Amanda Pernet ◽  
Brian Kendall ◽  
Anthony David
Keyword(s):  
Magnetic Resonance Imaging ◽  
White Matter ◽  
Magnetic Resonance ◽  
Cognitive Dysfunction ◽  
White Matter Lesions ◽  
Chronic Fatigue ◽  
Depressive Illness ◽  
Cerebral White Matter ◽  
Resonance Imaging ◽  
Fatigue Syndrome

BackgroundThis study examines whether cognitive dysfunction in chronic fatigue may be accounted for by depression and anxiety or is due to brain pathology evident on magnetic resonance imaging (MRI).MethodTwenty-six subjects with chronic fatigue, with and without coexisting depression, and 18 age-matched normal controls were recruited from primary care following a presumed viral illness six months previously. Comparison was made with 13 psychiatric controls with depressive illness on standardised cognitive tests. MRI determined the presence of cerebral white-matter lesions.ResultsNo substantial differences in performance were shown between subjects with chronic fatigue, most of whom met the criteria for chronic fatigue syndrome, and controls. Subjective cognitive dysfunction increased with psychopathology. White-matter lesions were found in a minority from all groups. Improvement in fatigue and depression coincided with improved performance on cognitive measures.ConclusionsSubjective complaints of cognitive impairment are a prominent feature of chronic fatigue, but objective cognitive and MRI abnormalities are not. Such complaints probably reflect psychopathology rather than a post-viral process.

Sign in / Sign up

Export Citation Format

Share Document