Early age-of-onset iron overload and homozygosity for the novel hemojuvelin mutation HJV R54X (exon 3; c.160A→T) in an African American male of West Indies descent

2008 ◽  
Vol 74 (1) ◽  
pp. 88-92 ◽  
Author(s):  
RC Murugan ◽  
PL Lee ◽  
MR Kalavar ◽  
JC Barton
2018 ◽  
Vol 50 (1) ◽  
pp. 63-82
Author(s):  
Tuula Kolehmainen

In this article, I discuss Toni Morrison’s 1981 novel, Tar Baby, through the lens of a trickster tale on which the novel is loosely based. Tar Baby invites one to choose sides between Jadine, the African American female protagonist with a European education and worldviews, or Son, the bearer of a more traditional African American cultural heritage and values. Son is initially constructed as other, and his representation is based on negative stereotypical notions of the African American male. First impressions need to be revised later, as the text plays with the readers’ sympathies about Son. Even his survival is left open at the end of the novel and the range of options of how to categorize Son would seem to reflect the readers’ perceptions back on themselves. In this way, Morrison sets up a trap in which any reader making too easy or essentialist definitions of the character will fall. Thus, the most important expression of the trickster tale is the novel’s name: the novel itself is the tar baby. Moreover, the most important construction of tar lies in the ambiguous representation of Son.


2018 ◽  
Vol 11 (2) ◽  
pp. 70-93
Author(s):  
Celeste Hawkins

This article focuses on findings from a subgroup of African-American male students as part of a broader qualitative dissertation research study, which explored how exclusion and marginalization in schools impact the lives of African-American students. The study focused on the perspectives of youth attending both middle and high schools in Michigan, and investigated how students who have experienced forms of exclusion in their K–12 schooling viewed their educational experiences. Key themes that emerged from the study were lack of care, lack of belonging, disrupted education, debilitating discipline, and persistence and resilience. These themes were analyzed in relation to their intersectionality with culture, ethnicity, race, class, and gender.


2021 ◽  
Vol 73 (1) ◽  
Author(s):  
Soumi Das ◽  
Sandeep Seth

Abstract Background Dilated cardiomyopathy (DCM) is a disease of the heart muscle characterized by ventricular dilation and a left ventricular ejection fraction of less than 40%. Unlike hypertrophic cardiomyopathy (HCM) and arrhythmogenic right ventricular cardiomyopathy (ARVC), DCM-causing mutations are present in a large number of genes. In the present study, we report a case of the early age of onset of DCM associated with a pathogenic variant in the RBM20 gene in a patient from India. Case presentation A 19-year-old Indian male diagnosed with DCM was suggested for heart transplantation. His ECG showed LBBB and echocardiography showed an ejection fraction of 14%. He had a sudden cardiac death. A detailed family history revealed it to be a case of familial DCM. Genetic screening identified the c.1900C>T variant in the RBM20 gene which led to a missense variant of amino acid 634 (p.Arg634Trp). Conclusion To the best of our knowledge, the variant p.Arg634Trp has been earlier reported in the Western population, but this is the first case of p.Arg634Trp in an Indian patient. The variant has been reported to be pathogenic at an early age of onset; therefore, close clinical follow-up should be done for the family members caring for the variant.


1990 ◽  
Vol 21 (2) ◽  
pp. 162-189 ◽  
Author(s):  
Yvonne R. Bell ◽  
Cathy L. Bouie ◽  
Joseph A. Baldwin

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