Solid organ transplantation in survivors of hematopoietic cell transplantation: a single institution case series and literature review

2010 ◽  
Vol 24 (4) ◽  
pp. E94-E102 ◽  
Author(s):  
Amer Beitinjaneh ◽  
Linda J. Burns ◽  
Navneet S. Majhail
Keyword(s):  
Literature Review ◽  
Organ Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Solid Organ Transplantation ◽  
Case Series ◽  
Hematopoietic Cell ◽  
Solid Organ ◽  
Single Institution

scholarly journals Allogeneic Hematopoietic Cell Transplantation for Therapy-Related Myeloid Leukemia following Orthotopic Cardiac Transplantation

2013 ◽  
Vol 2013 ◽  
pp. 1-3
Author(s):  
Richard J. Lin ◽  
Richard A. Larson ◽  
Koen van Besien ◽  
Elizabeth S. Rich
Keyword(s):  
Organ Transplantation ◽  
Cell Transplantation ◽  
Myeloid Leukemia ◽  
Cardiac Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Late Complication ◽  
Solid Organ Transplantation ◽  
Hematopoietic Cell ◽  
Allogeneic Hematopoietic Cell Transplantation ◽  
Solid Organ

Therapy-related myeloid neoplasm (t-MN) is a subtype of acute myeloid leukemia with adverse cytogenetics and poor overall prognosis despite intensive induction chemotherapy and allogeneic hematopoietic cell transplantation (allo-HCT). It is increasingly recognized as a late complication of chronic immunosuppression in patients who have received solid organ transplantation. In this paper, we describe a case of t-MN following orthotopic cardiac transplantation and its treatment with allo-HCT. We discuss molecular and biological challenges and considerations in double solid organ and bone marrow transplantation and review similar cases at our institution. Our experience suggests general feasibility and safety of allo-HCT in patients who have received solid organ transplantation.

scholarly journals Hematopoietic Cell Transplantation after Solid Organ Transplantation

2015 ◽  
Vol 21 (12) ◽  
pp. 2123-2128 ◽  
Author(s):  
Kristine C. Doney ◽  
Marco Mielcarek ◽  
F. Marc Stewart ◽  
Frederick R. Appelbaum
Keyword(s):  
Organ Transplantation ◽  
Cell Transplantation ◽  
Hematopoietic Cell Transplantation ◽  
Solid Organ Transplantation ◽  
Hematopoietic Cell ◽  
Solid Organ

scholarly journals Practice patterns for evaluation, consent, and care of related donors and recipients at hematopoietic cell transplantation centers in the United States

Blood ◽  
2010 ◽  
Vol 115 (24) ◽  
pp. 5097-5101 ◽  
Author(s):  
Paul V. O'Donnell ◽  
Tanya L. Pedersen ◽  
Dennis L. Confer ◽  
J. Douglas Rizzo ◽  
Michael A. Pulsipher ◽  
...  
Keyword(s):  
United States ◽  
Cell Transplantation ◽  
Conflict Of Interest ◽  
Medical Management ◽  
Hematopoietic Cell Transplantation ◽  
Practice Patterns ◽  
Solid Organ Transplantation ◽  
The United States ◽  
Hematopoietic Cell ◽  
Solid Organ

Abstract Conflict of interest may arise when 1 physician serves 2 persons whose medical care is interdependent. In hematopoietic cell transplantation (HCT) from unrelated donors and in the setting of solid organ transplantation from living donors, the standard of care is for donors and recipients to be managed by separate physicians to provide unbiased care. However, the practice patterns of evaluation and care of related donors and recipients are not well described. A survey of HCT centers in the United States was conducted by the Donor Health and Safety Working Committee of the Center for International Blood and Marrow Transplant Research to determine the type of provider involved in medical clearance, informed consent, and medical management of hematopoietic cell collection and the relationship of that provider to the HC transplant recipient. The response rate was 40%. In greater than 70% of centers, transplantation physicians were involved or potentially involved in overlapping care of the HC transplant donor and the recipient. These patterns were similar between transplantation teams caring for adult or pediatric donors and recipients. Among responding centers, medical management of recipients and their related donors by the same provider is common, a practice that has the potential for conflict of interest.

Transplantation

2019 ◽  
pp. 399-414
Author(s):  
Gavin Spickett
Keyword(s):  
Gene Therapy ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Organ Transplantation ◽  
Cell Transplantation ◽  
Graft Failure ◽  
Solid Organ Transplantation ◽  
Solid Organ ◽  
Graft Vs Host Disease ◽  
The Subject

This chapter covers the indications, methods, immunological considerations, and monitoring of various types of transplantation. Covering stem cell transplantation, gene therapy, graft vs host disease, graft failure, and solid organ transplantation, the chapter provides an immunological overview of the subject.

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