Fatal pristinamycin-induced toxic epidermal necrolysis (Lyell's syndrome): difficulties in attributing causal association in the polymedicated intensive care unit patient

2005 ◽  
Vol 49 (5) ◽  
pp. 721-722 ◽  
Author(s):  
G. Chanques ◽  
C. Girard ◽  
V. Pinzani ◽  
S. Jaber
2019 ◽  
Vol 2019 (10) ◽  
Author(s):  
Karishma Seomangal ◽  
Yasir Bashir ◽  
Michael Boland ◽  
Paul Neary

Abstract We present a case of an unexpected cause of bowel ischemia in an intensive care unit patient with herpes simplex virus encephalitis who required an operation. A 79-year-old lady was being worked up and treated for encephalitis with antibiotics and an antiviral. On Day 13, she developed abdominal pain, and an ultrasound showed cholelithiasis but no cholecystitis; thus conservative treatment was advocated. By Day 18, pain localized to the right iliac fossa, and she had an emergency laparotomy that showed bowel ischemia and perforation of the caecum with the cause being a terminal ileal adhesional band. An extended right hemicolectomy and ileostomy was performed. Patients with significant comorbidities who are intensive care unit-dependent may still have unexpected clinical challenges. We advocate an increased clinical vigilance in this cohort for unexpected life-threatening presentations such as bowel ischemia and more specifically the cause of the bowel ischemia.


1985 ◽  
Vol 144 (1) ◽  
pp. 91-93 ◽  
Author(s):  
Chr. Luderschmidt ◽  
O. Linderkamp ◽  
J. Ring

2015 ◽  
Vol 29 (4) ◽  
pp. 1044-1050 ◽  
Author(s):  
Adam S. Evans ◽  
Leila Hosseinian ◽  
Tricia Mohabir ◽  
Samuel Kurtis ◽  
Jeffrey I. Mechanick

2011 ◽  
Vol 2011 ◽  
pp. 1-3
Author(s):  
Zafer Onaran ◽  
Gülşah Usta ◽  
Mukadder Koçak ◽  
Kemal Örnek ◽  
Ünase Büyükkoçak

Aim. To describe a case of toxic epidermal necrolysis (TEN) with ocular involvement treated with topical ophthalmic cyclosporine.Case Presentation. A 20-year-old woman developed TEN following administration of carbamazepine that was prescribed for epilepsy. Ophthalmic examination revealed bilateral pseudomembranous conjunctivitis. She was hospitalized in the intensive care unit and treated with intravenous corticosteroid and immunoglobulin. Topical cyclosporine was used in combination with topical corticosteroids for ocular surface disease. Following two months of ocular treatment, she recovered without any severe ocular complication. Ocular examination at the four-month followup showed a 2 mm of symblepharon in the lower fornix as the sole pathologic finding.Conclusion. Topical ophthalmic cyclosporine may contribute to decrease the ophthalmic complications of TEN and should be considered in the acute stage of the disease.


Author(s):  
VATHSALYA PORANKI

Organophosphate compounds are used as commercial insecticides and applied as aerosols or dust. Consuming these compounds intentionally or unintentionally lead to dangerous conditions even to fatality. The most common obstacle in treating organophosphorus poisoning is the availability of sufficient medical care, equipment to provide proper emergency care observed in rural areas where there is a lot of gap between intensive care and acute care. Atropine use is as an antidote in organophosphorus poisoning. The dose of atropine mainly depends on the organophosphorus toxic doses. Atropine is a competitive antagonist of acetylcholine at the muscarinic postsynaptic membrane. Atropine blocks all the muscarinic effects in the body. This study presents a case of organophosphorus poisoning treated with atropine leading to atropine psychosis. Patient’s conditions, outcomes, and improvements are studied.


Medical Care ◽  
2018 ◽  
Vol 56 (10) ◽  
pp. 890-897 ◽  
Author(s):  
Eduard E. Vasilevskis ◽  
Rameela Chandrasekhar ◽  
Colin H. Holtze ◽  
John Graves ◽  
Theodore Speroff ◽  
...  

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