BMP signaling in the control of skin development and hair follicle growth

2004 ◽  
Vol 72 (9-10) ◽  
pp. 512-526 ◽  
Author(s):  
Vladimir A. Botchkarev ◽  
Andreij A. Sharov
Keyword(s):  
Hair Follicle ◽  
Bmp Signaling ◽  
Follicle Growth ◽  
Skin Development ◽  
Hair Follicle Growth

scholarly journals The Wave complex controls epidermal morphogenesis and proliferation by suppressing Wnt–Sox9 signaling

2019 ◽  
Vol 218 (4) ◽  
pp. 1390-1406 ◽  
Author(s):  
Jonathan Cohen ◽  
Shaul Raviv ◽  
Orit Adir ◽  
Krishnanand Padmanabhan ◽  
Arad Soffer ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Loss Of Function ◽  
Filamentous Actin ◽  
Follicle Growth ◽  
Cell Specification ◽  
Skin Development ◽  
Interfollicular Epidermis ◽  
Hair Follicle Growth ◽  
Spatiotemporal Control ◽  
Wave Complex

Development of the skin epidermis requires tight spatiotemporal control over the activity of several signaling pathways; however, the mechanisms that orchestrate these events remain poorly understood. Here, we identify a key role for the Wave complex proteins ABI1 and Wave2 in regulating signals that control epidermal shape and growth. In utero RNAi-mediated silencing of Abi1 or Wasf2 induced cellular hyperproliferation and defects in architecture of the interfollicular epidermis (IFE) and delayed hair follicle growth. Unexpectedly, SOX9, a hair follicle growth regulator, was aberrantly expressed throughout the IFE of the mutant embryos, and its forced overexpression mimicked the Wave complex loss-of-function phenotype. Moreover, Wnt signaling, which regulates SOX9+ cell specification, was up-regulated in Wave complex loss-of-function IFE. Importantly, we show that the Wave complex regulates filamentous actin content and that a decrease in actin levels is sufficient to elevate Wnt/β-catenin signaling. Our results identify a novel role for Wave complex– and actin-regulated signaling via Wnt and SOX9 in skin development.

ANXA1 affects murine hair follicle growth through EGF signaling pathway

Gene ◽  
2021 ◽  
Vol 771 ◽  
pp. 145343
Author(s):  
Hao Zhang ◽  
Xiaoqiao Fu ◽  
Yue Ao ◽  
Miaomiao Nan ◽  
Ziyu Qiu ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Signaling Pathway ◽  
Follicle Growth ◽  
Hair Follicle Growth ◽  
Egf Signaling

Control of the hair follicle growth cycle

2000 ◽  
pp. 83-94
Author(s):  
Ralf Paus ◽  
Sven Müller-Röver ◽  
Ian McKay
Keyword(s):  
Hair Follicle ◽  
Growth Cycle ◽  
Follicle Growth ◽  
Hair Follicle Growth

Engineered extracellular vesicle mimetics from macrophage promotes hair growth in mice and promotes human hair follicle growth

2021 ◽  
pp. 112887
Author(s):  
Ramya Lakshmi Rajendran ◽  
Prakash Gangadaran ◽  
Mi Hee Kwack ◽  
Ji Min Oh ◽  
Chae Moon Hong ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Human Hair ◽  
Hair Growth ◽  
Extracellular Vesicle ◽  
Follicle Growth ◽  
Human Hair Follicle ◽  
Hair Follicle Growth
Sign in / Sign up

Export Citation Format

Share Document