Inhibition of Phosphatidylinositol 3-Kinase Blocks T Cell Antigen Receptor/CD3-Induced Activation of the Mitogen-Activated Kinase Erk2

European Journal of Biochemistry ◽

10.1111/j.1432-1033.1996.00828.x ◽

1996 ◽

Vol 235 (3) ◽

pp. 828-835 ◽

Author(s):

Maria Willebrand ◽

Thomas Jascur ◽

Nathalie Bonnefoy-Berard ◽

Hiroshi Yano ◽

Amnon Altman ◽

...

Keyword(s):

T Cell ◽

Antigen Receptor ◽

Phosphatidylinositol 3 Kinase ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Phosphatidylinositol 3

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Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)35916-7 ◽

1992 ◽

Vol 267 (33) ◽

pp. 23862-23869

Author(s):

S.G. Ward ◽

K Reif ◽

S Ley ◽

M.J. Fry ◽

M.D. Waterfield ◽

...

Keyword(s):

T Cells ◽

T Cell ◽

Tyrosine Kinases ◽

Antigen Receptor ◽

Phosphatidylinositol 3 Kinase ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Phosphatidylinositol 3

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Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction

Molecular Immunology ◽

10.1016/s0161-5890(97)00027-8 ◽

1997 ◽

Vol 34 (3) ◽

pp. 221-226 ◽

Author(s):

M Exley

Keyword(s):

Signal Transduction ◽

T Cell ◽

Antigen Receptor ◽

Phosphatidylinositol 3 Kinase ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Tcr Signal Transduction ◽

Phosphatidylinositol 3

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Tyrosine Phosphorylation of the CD3-ε Subunit of the T Cell Antigen Receptor Mediates Enhanced Association with Phosphatidylinositol 3-Kinase in Jurkat T Cells

Journal of Biological Chemistry ◽

10.1074/jbc.272.40.25310 ◽

1997 ◽

Vol 272 (40) ◽

pp. 25310-25318 ◽

Author(s):

Isabel de Aós ◽

Markus H. Metzger ◽

Mark Exley ◽

Charles E. Dahl ◽

Suniti Misra ◽

...

Keyword(s):

T Cells ◽

T Cell ◽

Tyrosine Phosphorylation ◽

Antigen Receptor ◽

Phosphatidylinositol 3 Kinase ◽

Jurkat T Cells ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Phosphatidylinositol 3

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Cutting Edge: Gab2 Mediates an Inhibitory Phosphatidylinositol 3′-Kinase Pathway in T Cell Antigen Receptor Signaling

The Journal of Immunology ◽

10.4049/jimmunol.165.8.4158 ◽

2000 ◽

Vol 165 (8) ◽

pp. 4158-4163 ◽

Author(s):

Joanne C. Pratt ◽

Vivien E. Igras ◽

Hiroyuki Maeda ◽

Shairaz Baksh ◽

Erwin W. Gelfand ◽

...

Keyword(s):

T Cell ◽

Antigen Receptor ◽

Cutting Edge ◽

Receptor Signaling ◽

Phosphatidylinositol 3 Kinase ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Antigen Receptor Signaling ◽

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Faculty Opinions recommendation of Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1007978.115962 ◽

2002 ◽

Author(s):

Roger Williams

Keyword(s):

T Cell ◽

Antigen Receptor ◽

Mutant Mice ◽

Receptor Signaling ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Antigen Receptor Signaling

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Faculty Opinions recommendation of Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1007978.109814 ◽

2002 ◽

Author(s):

Marie Kosco-Vilbois

Keyword(s):

T Cell ◽

Antigen Receptor ◽

Mutant Mice ◽

Receptor Signaling ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Antigen Receptor Signaling

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Faculty Opinions recommendation of Dynamic molecular interactions linking the T cell antigen receptor to the actin cytoskeleton.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022661.260651 ◽

2004 ◽

Author(s):

Sergio Grinstein

Keyword(s):

T Cell ◽

Actin Cytoskeleton ◽

Molecular Interactions ◽

Antigen Receptor ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

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Faculty Opinions recommendation of Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs ensures effective negative selection and prevents autoimmunity.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1108753.564866 ◽

2008 ◽

Author(s):

Scott Gray-Owen

Keyword(s):

T Cell ◽

Negative Selection ◽

Antigen Receptor ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

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Faculty Opinions recommendation of Vitamin D controls T cell antigen receptor signaling and activation of human T cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2517956.2321060 ◽

2010 ◽

Author(s):

Gerald Spangrude

Keyword(s):

Vitamin D ◽

T Cells ◽

T Cell ◽

Antigen Receptor ◽

Receptor Signaling ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Antigen Receptor Signaling ◽

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Faculty Opinions recommendation of Vitamin D controls T cell antigen receptor signaling and activation of human T cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.2517956.2163054 ◽

2010 ◽

Author(s):

Luciano Adorini

Keyword(s):

Vitamin D ◽

T Cells ◽

T Cell ◽

Antigen Receptor ◽

Receptor Signaling ◽

T Cell Antigen Receptor ◽

Cell Antigen Receptor ◽

Cell Antigen ◽

Antigen Receptor Signaling ◽

Download Full-text