Further Investigations on Hydroxyproline Excretion in Bovine Puerperal paresis

1. Blood flow to the skeleton was measured by the 18F clearance method of Wootton, Reeve & Veall (1976) in 24 patients with untreated Paget's disease. In every patient but one, resting skeletal blood flow was increased. There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal blood flow, alkaline phosphatase and urinary hydroxyproline excretion fell towards normal in every case. There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase. 3. Glomerular filtration rate appeared to increase transiently in response to calcitonin.

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Hydroxyproline Excretion in the Detection of Occult Bone Metastases from Breast Cancer

Oncology ◽

10.1159/000225653 ◽

1982 ◽

Vol 39 (5) ◽

pp. 287-291 ◽

Cited By ~ 1

Author(s):

A.D. Rowse ◽

M.J. Morrison ◽

P.H. Scott ◽

A.J. Banks ◽

C. Roginski

Keyword(s):

Breast Cancer ◽

Bone Metastases ◽

Hydroxyproline Excretion

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COMPARISON BETWEEN THE 5,6-CIS AND 5,6-TRANS ISOMERS OF 25-HYDROXYVITAMIN D3 IN CHRONIC HYPOPARATHYROIDISM

Acta Endocrinologica ◽

10.1530/acta.0.0860784 ◽

1977 ◽

Vol 86 (4) ◽

pp. 784-793 ◽

Cited By ~ 2

Author(s):

Gerd Offermann ◽

Dieter Kraft

Keyword(s):

Serum Calcium ◽

Calcium Release ◽

Calcium Absorption ◽

Intestinal Calcium Absorption ◽

Normal Range ◽

Hydroxyvitamin D ◽

25 Hydroxyvitamin D ◽

One Year ◽

Hydroxyproline Excretion ◽

Chronic Hypoparathyroidism

ABSTRACT Five patients with chronic post-operative hypoparathyroidism were treated with 450 μg/day 5,6-trans-25-hydroxyvitamin D3 (5,6-trans-25OHD3) for 14 days, and the treatment was continued with 150 μg/day for one year. At the end of this period the patients received 450 μg/day 5,6-cis-25-hydroxyvitamin D3 (5,6-cis-25OHD3) for 14 days. Comparison of the effects of both isomers revealed a similar ability to enhance intestinal calcium absorption and to normalize serum calcium; serum phosphate and alkaline phosphatase, however, remained unaffected. Urinary phosphate and hydroxyproline excretion decreased on the cis-isomer and increased on the trans-isomer. During treatment with the lower dose of 5,6-trans-25OHD3 intestinal calcium absorption remained in the normal range for one year, whereas the serum calcium decreased to the levels observed before administration of 450 μg/day within 6 weeks. The results suggest that in hypoparathyroidism 5,6-cis-25OHD3 and 5,6-trans-25OHD3 are equally effective on serum calcium and on intestinal calcium absorption, but that their mode of action on renal phosphate handling and on calcium release from bone is different.

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