INTESTINAL BLOOD FLOW IN THE DOG MEASURED BY INDICATOR FRACTIONATION WITHOUT TISSUE SAMPLES

1977 ◽  
Vol 4 (2) ◽  
pp. 235-245 ◽  
Author(s):  
M. N. Eade ◽  
I. R. Reid ◽  
J. P. Quinn
Keyword(s):  
Blood Flow ◽  
Intestinal Blood Flow ◽  
Tissue Samples

Vasodilation or altered perfusion pressure moves 15-micrometers spheres trapped in the gut wall

1982 ◽  
Vol 243 (1) ◽  
pp. H123-H127
Author(s):  
L. C. Maxwell ◽  
A. P. Shepherd ◽  
G. L. Riedel
Keyword(s):  
Blood Flow ◽  
Perfusion Pressure ◽  
Venous Blood ◽  
Intestinal Blood Flow ◽  
Experimental Conditions ◽  
Tissue Samples ◽  
Intestinal Segments ◽  
Microsphere Method ◽  
Adjacent Segments ◽  
Isoproterenol Infusion

To determine whether the microsphere method for measuring the intramural distribution of intestinal blood flow is affected by perfusion pressure or vasodilation, we infused radioactive 9- and 15-micrometers spheres into adjacent segments of isolated canine small bowel. After sphere infusion the blood supply of the control loop was occluded, and the vasculature of the experimental loop was either dilated by infusing isoproterenol or was subjected to increased perfusion pressure. Intestinal segments were dissected into mucosal, submucosal, and muscularis samples. Venous blood was collected during sphere infusions and experimental perturbations. Accumulations of spheres in tissue samples and venous blood were assessed in a gamma radioactivity counter. Isoproterenol caused previously infused spheres to leave submucosa and redistributed them primarily to mucosa with few additional spheres reaching venous blood. An increase in perfusion pressure also dislodged spheres from submucosa, but these did reach venous blood. The combined estimate of mucosal plus submucosal blood flow was relatively unaffected by isoproterenol infusion but was significantly altered by increased perfusion pressure. These results have the following implications for microsphere studies of the intramural distribution of intestinal blood flow: 1) tissue must be sampled after each sphere infusion unless the possibility of sphere migration has been experimentally eliminated and 2) even a two-compartment fractionation of blood flow into muscularis and mucosal-plus-submucosal compartments is not valid under some experimental conditions.

The effect of the chinese herbal medicine Dai-Kenchu-To on intestinal blood flow

2001 ◽  
Vol 120 (5) ◽  
pp. A248-A248
Author(s):  
N KAWASAKI ◽  
K NARIAI ◽  
M NAKAO ◽  
K NAKADA ◽  
N HANYUU ◽  
...  
Keyword(s):  
Blood Flow ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Intestinal Blood Flow ◽  
Chinese Herbal

Blood flow and high-energy phosphates in microregions of left ventricular subendocardium

1981 ◽  
Vol 240 (5) ◽  
pp. H804-H810 ◽  
Author(s):  
H. D. Kleinert ◽  
H. R. Weiss
Keyword(s):  
Blood Flow ◽  
Linear Relationship ◽  
Tissue Perfusion ◽  
High Energy ◽  
Left Ventricular ◽  
Significant Loss ◽  
Tissue Blood Flow ◽  
High Energy Phosphates ◽  
Tissue Samples ◽  
Heterogeneous Distribution

Blood flow and high-energy phosphate (HEP) content were determined simultaneously in multiple microregions of left ventricular subendocardium in 29 normal anesthetized open-chest rabbits by use of a new micromethod to determine whether a direct linear relationship existed between these parameters. Tissue samples weighed 1-2 mg. ATP and creatine phosphate (CP) content were quantitated in quick-frozen hearts by fluorometry at sites where tissue perfusion was measured by H2 clearance by use of bare-tipped platinum electrodes. A series of validation studies were conducted to ensure that 1) no significant damage to the tissue surrounding the electrode occurred during the period of experimentation and 2) no significant loss of biochemical constituents had occurred due to labile processes during freezing or storage of the tissue. Blood flow, ATP, and CP values averaged 79.1 +/- 24.1 (SD) ml.min-1.100 g-1, 4.9 +/- 1.3 mumol/g tissue, and 8.0 +/- 3.0 mumol/g tissue, respectively, and are similar to those reported in studies using larger tissue samples. Correlation between the heterogeneous distribution of tissue perfusion and HEP revealed no direct linear relationship between these parameters in the normal unstressed rabbit subendocardium.

The effect of early-onset preeclampsia on the intestinal blood flow of preterm infants

2019 ◽  
pp. 1-5 ◽  
Author(s):  
Simone Manso de Carvalho Pelicia ◽  
Saskia Maria Wiegerinck Fekete ◽  
José Eduardo Corrente ◽  
Ligia Maria Suppo de Souza Rugolo
Keyword(s):  
Blood Flow ◽  
Preterm Infants ◽  
Early Onset ◽  
Intestinal Blood Flow ◽  
Early Onset Preeclampsia

Effects of nicotine on canine intestinal blood flow and oxygen consumption

1984 ◽  
Vol 246 (2) ◽  
pp. G195-G203
Author(s):  
R. H. Gallavan ◽  
Y. Tsuchiya ◽  
E. D. Jacobson
Keyword(s):  
Blood Pressure ◽  
Blood Flow ◽  
Oxygen Consumption ◽  
Muscle Tension ◽  
Intestinal Blood Flow ◽  
Mesenteric Blood Flow ◽  
State Response ◽  
Arterial Blood ◽  
Intestinal Circulation

The purpose of this study was to determine the effects of nicotine on intestinal blood flow and oxygen consumption. The intravenous infusion of nicotine at doses corresponding to those experienced by smokers produced a transient increase in systemic arterial blood pressure and mesenteric blood flow. Subsequently a steady-state response developed that consisted of a reduction in mesenteric blood flow due to both a decrease in blood pressure and an increase in intestinal vascular resistance. This increase in resistance was probably due to increased levels of circulating catecholamines. The intra-arterial infusion of nicotine into the intestinal circulation at doses experienced by the average smoker had no effect on either intestinal blood flow or oxygen consumption. Similarly, under in vitro conditions nicotine had no direct effect on intestinal vascular smooth muscle tension. Thus, nicotine appears to reduce intestinal blood flow indirectly as a result of its systemic effects.

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