Association between brachial-ankle pulse wave velocity and endothelium-dependent and -independent coronary vasomotor function

Background Endothelial dysfunction decrease vasomotor function and cause vascular stiffening in addition to the structural changes. Relative L-arginine deficiency to ADMA influencing NO synthesis may increase arterial stiffness in elderly individuals. We investigated the relationship between the L-arginine / ADMA ratio and brachial ankle pulse wave velocity (baPWV) of the patients with suspected or already known coronary artery disease (CAD). Methods and Results The cross-sectional study enrolled 74 patients (67 ± 10 y/o) undergoing coronary angiography. There were 54 (73%) patients with CAD including 3 of coronary bypass surgery, and 11 of old myocardial infarction. Exclusion criteria were ankle brachial index (ABI) less than 0.9 in both lower extremities and hemodialysis. baPWV and ABI were obtained using an automatic waveform analyzer. Serum L-arginine, ADMA were measured by high-performance liquid chromatography. The ratio of L-arginine to ADMA was associated with baPWV (γ= -0.323, p=0.005) (Figure). Although the value of baPWV was dependent on systolic blood pressure and heart rate at measurement as reported previously, the ratio was a significant predictor of baPWV in multivariate analysis (β= -0.448, p<0.001). Additionally, serum L-arginine, and L-arginine / ADMA ratio were also independent contributing factors to baPWV in the subgroup of 46 elderly patients (>64 y/o). Conclusion We observed that many ageing patients with cardiovascular disease had low L-arginine / ADMA ratio accompanied with high baPWV. The findings suggested that correction of serum L-arginine level can be a therapeutic option to recover arterial compliance for the population.

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Improvement in Brachial Endothelial Vasomotor Function and Brachial-Ankle Pulse Wave Velocity Reduces the Residual Risk for Cardiovascular Events after Optimal Medical Treatment in Patients with Coronary Artery Disease

Journal of Atherosclerosis and Thrombosis ◽

10.5551/jat.57562 ◽

2020 ◽

Cited By ~ 1

Author(s):

Takamitsu Nakamura ◽

Manabu Uematsu ◽

Takeo Horikoshi ◽

Toru Yoshizaki ◽

Tsuyoshi Kobayashi ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Pulse Wave Velocity ◽

Medical Treatment ◽

Wave Velocity ◽

Cardiovascular Events ◽

Pulse Wave ◽

Residual Risk ◽

Vasomotor Function ◽

Artery Disease

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M.555 Assessing pulse wave velocity and biophysical properties of the aorta in patients with end-stage renal disease

Atherosclerosis ◽

10.1016/s0021-9150(04)90553-9 ◽

2004 ◽

Vol 5 (1) ◽

pp. 128-129

Author(s):

D KARAKITSOS

Keyword(s):

Pulse Wave Velocity ◽

Renal Disease ◽

Wave Velocity ◽

End Stage Renal Disease ◽

Pulse Wave ◽

Biophysical Properties ◽

Stage Renal Disease ◽

End Stage

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M.572 Invasive measurements of pulse wave velocity correlate with the degree of echocardiographic aortic valve calcification and its severity in aged patients with degenerative aortic valve stenosis

Atherosclerosis ◽

10.1016/s0021-9150(04)90570-9 ◽

2004 ◽

Vol 5 (1) ◽

pp. 132-133 ◽

Cited By ~ 1

Author(s):

P LIU

Keyword(s):

Aortic Valve ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Aortic Valve Stenosis ◽

Pulse Wave ◽

Aortic Valve Calcification ◽

Aged Patients ◽

Valve Calcification

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Pulse wave velocity rather than atherosclerotic markers describe vascular status of patients with type 2 diabetes mellitus

10.1055/s-0038-1641893 ◽

2018 ◽

Author(s):

B Stratmann ◽

M Rydzkowski ◽

D Tschöpe

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Vascular Status

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Augmentation Index und Pulse Wave Velocity in Schwangerschaften mit Präeklampsie oder Gestationsdiabetes

Zeitschrift für Geburtshilfe und Neonatologie ◽

10.1055/s-2007-1002846 ◽

2007 ◽

Vol 211 (S 2) ◽

Author(s):

B Schiessl ◽

M Burgmann ◽

V Sauer ◽

A Neubauer ◽

F Kainer ◽

...

Keyword(s):

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Wave ◽

Augmentation Index

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STRUCTURAL AND FUNCTIONAL VASCULAR CHANGES IN HIGH NORMAL ARTERIAL PRESSURE

BULGARIAN JOURNAL OF VETERINARY MEDICINE ◽

10.15547//tjs.2020.01.002 ◽

2020 ◽

Vol 23 (1) ◽

pp. 7-11

Author(s):

P. Nikolov

Keyword(s):

Arterial Pressure ◽

Pulse Wave Velocity ◽

Wave Velocity ◽

Pulse Pressure ◽

Pulse Wave ◽

Augmentation Index ◽

Aortic Pressure ◽

Large Arteries ◽

Central Aortic Pressure ◽

Significant Difference

The PURPUSE of the present study is changes in function and structure of large arteries in individuals with High Normal Arterial Pressure (HNAP) to be established. MATERIAL and METHODS: Structural and functional changes in the large arteries were investigated in 80 individuals with HNAP and in 45 with optimal arterial pressure (OAP). In terms of arterial stiffness, pulse wave velocity (PWV), augmentation index (AI), central aortic pressure (CAP), pulse pressure (PP) were followed up in HNAP group. Intima media thickness (IMT), flow-induced vasodilatation (FMD), ankle-brachial index (ABI) were also studied. RESULTS: Significantly increased values of pulse wave velocity, augmentation index, central aortic pressure, pulse pressure are reported in the HNAP group. In terms of IMT and ABI, being in the reference interval, there is no significant difference between HNAP and OAP groups. The calculated cardiovascular risk (CVR) in both groups is low. CONCLUSION: Significantly higher values of pulse wave velocity, augmentation index, central aortic pressure and pulse pressure in the HNAP group are reported.

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