Higher importance of interleukin 6 than classic tumor markers (carcinoembryonic antigen and squamous cell cancer antigen) in the diagnosis of esophageal cancer patients

2011 ◽  
Vol 25 (3) ◽  
pp. 242-249 ◽  
Author(s):  
M. Łukaszewicz-Zając ◽  
B. Mroczko ◽  
M. Kozłowski ◽  
J. Nikliński ◽  
J. Laudański ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Carcinoembryonic Antigen ◽  
Cancer Patients ◽  
Tumor Markers ◽  
Squamous Cell ◽  
Interleukin 6 ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Cancer Antigen

The diagnostic value of the measurement of matrix metalloproteinase 9 (MMP-9), squamous cell cancer antigen (SCC) and carcinoembryonic antigen (CEA) in the sera of esophageal cancer patients

2008 ◽  
Vol 389 (1-2) ◽  
pp. 61-66 ◽  
Author(s):  
Barbara Mroczko ◽  
Mirosław Kozłowski ◽  
Magdalena Groblewska ◽  
Marta Łukaszewicz ◽  
Jacek Nikliński ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Matrix Metalloproteinase ◽  
Carcinoembryonic Antigen ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Diagnostic Value ◽  
Cancer Antigen ◽  
Metalloproteinase 9

scholarly journals The Serum Concentrations of Chemokine CXCL12 and Its Specific Receptor CXCR4 in Patients with Esophageal Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Marta Łukaszewicz-Zając ◽  
Barbara Mroczko ◽  
Mirosław Kozłowski ◽  
Maciej Szmitkowski
Keyword(s):  
Esophageal Cancer ◽  
Tumor Markers ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Serum Concentrations ◽  
C Reactive Protein ◽  
Specific Receptor ◽  
Cancer Antigen ◽  
Reactive Protein ◽  
Chemokine Cxcl12

Objectives.Recent investigations have suggested that upregulated levels of inflammatory biomarkers, such as chemokines, may be associated with development of many malignancies, including esophageal cancer (EC). Based on our knowledge, this study is the first to assess the serum concentration of chemokine CXCL12 and its specific receptor CXCR4 in the diagnosis of EC patients.Material and Methods.The present study included 79 subjects: 49 patients with EC and 30 healthy volunteers. The serum concentrations of CXCL12 and CXCR4 and classical tumor markers such as carcinoembryonal antigen (CEA) and squamous cell cancer antigen (SCC-Ag) were measured using immunoenzyme assays, while C-reactive protein (CRP) levels were assessed by immunoturbidimetric method. Moreover, diagnostic criteria of all proteins tested and the survival of EC patients were assessed.Results.The serum concentrations of CXCL12 were significantly higher, while those of its receptor CXCR4 were significantly lower in EC patients compared to healthy controls. The diagnostic sensitivity, negative predictive value, and accuracy of CXCR4 were the highest among all analyzed proteins and increased for combined analysis with classical tumor markers and CRP levels.Conclusion.Our findings suggest that serum CXCR4 may improve the diagnosis of EC patients, especially in combination with classical tumor markers.

scholarly journals Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu-Chieh Ho ◽  
Yuan-Chun Lai ◽  
Hsuan-Yu Lin ◽  
Ming-Hui Ko ◽  
Sheng-Hung Wang ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Performance Status ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer ◽  
Lymphocyte Ratio ◽  
Cardiac Dose

AbstractWe aimed to determine the prognostic significance of cardiac dose and hematological immunity parameters in esophageal cancer patients after concurrent chemoradiotherapy (CCRT). During 2010–2015, we identified 101 newly diagnosed esophageal squamous cell cancer patients who had completed definitive CCRT. Patients' clinical, dosimetric, and hematological data, including absolute neutrophil count, absolute lymphocyte count, and neutrophil-to-lymphocyte ratio (NLR), at baseline, during, and post-CCRT were analyzed. Cox proportional hazards were calculated to identify potential risk factors for overall survival (OS). Median OS was 13 months (95% confidence interval [CI]: 10.38–15.63). Univariate analysis revealed that male sex, poor performance status, advanced nodal stage, higher percentage of heart receiving 10 Gy (heart V10), and higher NLR (baseline and follow-up) were significantly associated with worse OS. In multivariate analysis, performance status (ECOG 0 & 1 vs. 2; hazard ratio [HR] 3.12, 95% CI 1.30–7.48), heart V10 (> 84% vs. ≤ 84%; HR 2.24, 95% CI 1.26–3.95), baseline NLR (> 3.56 vs. ≤ 3.56; HR 2.36, 95% CI 1.39–4.00), and follow-up NLR (> 7.4 vs. ≤ 7.4; HR 1.95, 95% CI 1.12–3.41) correlated with worse OS. Volume of low cardiac dose and NLR (baseline and follow-up) were associated with worse patient survival.

Clinicopathological association of p16 and its impact on outcome of chemoradiation in head-and-neck squamous cell cancer patients in North-East India

2020 ◽  
Vol 6 (1) ◽  
pp. 10
Author(s):  
YumkhaibamSobita Devi ◽  
Srigopal Mohanty ◽  
NithinRaj Daniel ◽  
DulasiRaman Ponna ◽  
Madhubala Devi ◽  
...  
Keyword(s):  
Head And Neck ◽  
Cancer Patients ◽  
Squamous Cell ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
North East India ◽  
North East ◽  
Neck Squamous Cell Cancer

scholarly journals Outcomes of concurrent chemoradiotherapy versus chemotherapy alone for esophageal squamous cell cancer patients presenting with oligometastases

2019 ◽  
Vol 11 (4) ◽  
pp. 1536-1545 ◽  
Author(s):  
Yongshun Chen ◽  
◽  
Xinyu Cheng ◽  
Haixia Song ◽  
Abraham J. Wu ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Squamous Cell ◽  
Concurrent Chemoradiotherapy ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer

scholarly journals Prognostic value of tumor length and diameter for esophageal squamous cell cancer patients treated with definitive (chemo)radiotherapy: Potential indicators for nonsurgical T staging

2019 ◽  
Vol 8 (14) ◽  
pp. 6326-6334
Author(s):  
Hongyao Xu ◽  
Shengxi Wu ◽  
Hesan Luo ◽  
Chuyun Chen ◽  
Lianxing Lin ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Squamous Cell ◽  
Prognostic Value ◽  
Squamous Cell Cancer ◽  
Cell Cancer ◽  
Esophageal Squamous Cell Cancer ◽  
Tumor Length
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