CONTACT ULTRA-HIGH MAGNIFYING ENDOSCOPY CAN DIFFERENTIATE SQUAMOUS CELL CARCINOMA FROM NON-CANCEROUS SQUAMOUS CELLS IN THE ESOPHAGUS: TWO CASES OF SUPERFICIAL ESOPHAGEAL CARCINOMA

2007 ◽  
Vol 19 (s1) ◽  
pp. S160-S165
Author(s):  
Mitsuru Kaise ◽  
Ken-ich Goda ◽  
Yukinaga Yoshida ◽  
Jin Yonezawa ◽  
Masayuki Kato ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Magnifying Endoscopy ◽  
Squamous Cells ◽  
Superficial Esophageal Carcinoma

Pseudoangiosarcomatous squamous cell carcinoma: first case report on penis.

2020 ◽  
Author(s):  
Liseana de Oliveira Barbosa ◽  
José Osvaldo Barbosa Neto ◽  
Antônio Augusto Lima Teixera Junior ◽  
Leudivan Ribeiro Nogueira ◽  
José de Ribamar Rodrigues Calixto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Papilloma Virus ◽  
Squamous Cells ◽  
First Case ◽  
Macroscopic Findings ◽  
Atypical Keratinocytes ◽  
E6 Protein

Abstract Background: Pseudoangiosarcomatous squamous cell carcinoma, also called pseudovascular, pseudoangiomatoid or adenoid pseudovascular carcinoma, is an uncommon and highly aggressive variant of squamous cell carcinoma. Histologically, it is characterized by proliferation of atypical keratinocytes with acantholysis and formation of pseudovascular spaces, forming anastomosed channels lined with neoplastic cells that invade the dermis. These cells are positive for cytokeratin and vimentin and negative for vascular markers such as CD31 and CD34. There are few reports of this tumor variant in the literature. Skin, breast, lung and vulva involvement have been described. But to the best of our knowledge, no cases involving the penis have been described. This article aims to describe the first case of angiosarcomatous squamous cell carcinoma of the penis. Case Report: The patient presented with a painful lesion in the penis associated with urinary retention. Macroscopic findings exhibited an ulcerative vegetating lesion that involving the entire glans and part of the penile body, as well as infiltration of penile structures and scrotal skin. Microscopy shows atypical proliferation of sarcomatous keratinocyte pattern mimicking vascular spaces. These neoplastic squamous cells were positive for the cytokeratin marker and were negative for the CD31 and CD34 markers. Human papilloma virus biomarkers, p16, E6 protein and PCR, were all negative. Conclusion: This report presents the first reported case of penile pseudoangiosarcomatous squamous cell carcinoma, as an important differential diagnosis.

Abstract 3024: FGFR1 amplification is linked to the squamous cell carcinoma subtype in esophageal carcinoma.

2013 ◽  
Author(s):  
Katharina von Loga ◽  
Jule Kohlhaussen ◽  
Andreas H. Marx ◽  
Guido Sauter ◽  
Tobias Grob ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell

BENEFICIAL USE OF MAGNIFYING ENDOSCOPY WITH NARROW-BAND IMAGING FOR DIAGNOSING A PATIENT WITH SQUAMOUS CELL CARCINOMA OF THE ANAL CANAL

2011 ◽  
Vol 24 (1) ◽  
pp. 42-45 ◽  
Author(s):  
TOMOHITO MORISAKI ◽  
HAJIME ISOMOTO ◽  
YUKO AKAZAWA ◽  
NAOYUKI YAMAGUCHI ◽  
KEN OHNITA ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Anal Canal ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Magnifying Endoscopy ◽  
Beneficial Use

scholarly journals Auraptene Attenuates Malignant Properties of Esophageal Stem-Like Cancer Cells

2016 ◽  
Vol 16 (4) ◽  
pp. 519-527 ◽  
Author(s):  
Saffiyeh Saboor-Maleki ◽  
Fatemeh B. Rassouli ◽  
Maryam M. Matin ◽  
Mehrdad Iranshahi
Keyword(s):  
Polymerase Chain Reaction ◽  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Esophageal Carcinoma ◽  
Cell Carcinoma ◽  
Cancer Cells ◽  
Real Time ◽  
Squamous Cell ◽  
Chain Reaction ◽  
Polymerase Chain

The high incidence of esophageal squamous cell carcinoma has been reported in selected ethnic populations including North of Iran. Low survival rate of esophageal carcinoma is partially due to the presence of stem-like cancer cells with chemotherapy resistance. In the current study, we aimed to determine the effects of auraptene, an interesting dietary coumarin with various biological activities, on malignant properties of stem-like esophageal squamous cell carcinoma, in terms of sensitivity to anticancer drugs and expression of specific markers. To do so, the half maximal inhibitory concentration values of auraptene, cisplatin, paclitaxel, and 5-fluorouracil were determined on esophageal carcinoma cells (KYSE30 cell line). After administrating combinatorial treatments, including nontoxic concentrations of auraptene + cisplatin, paclitaxel, or 5-fluorouracil, sensitivity of cells to chemical drugs and also induced apoptosis were assessed. In addition, quantitative real-time polymerase chain reaction was used to study changes in the expression of tumor suppressor proteins 53 and 21 ( P53 and P21), cluster of differentiation 44 ( CD44), and B cell-specific Moloney murine leukemia virus integration site 1 ( BMI-1) upon treatments. Results of thiazolyl blue assay revealed that auraptene significantly ( P < .05) increased toxicity of cisplatin, paclitaxel, and 5-fluorouracil in KYSE30 cells, specifically 72 hours after treatment. Conducting an apoptosis assay using flow cytometry also confirmed the synergic effects of auraptene. Results of quantitative real-time polymerase chain reaction revealed significant ( P < .05) upregulation of P53 and P21 upon combinatorial treatments and also downregulation of CD44 and BMI-1 after auraptene administration. Current study provided evidence, for the first time, that auraptene attenuates the properties of esophageal stem-like cancer cells through enhancing sensitivity to chemical agents and reducing the expression of CD44 and BMI-1 markers.

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