Advanced extragonadal yolk sac tumor serially followed up with 18F-fluorodexyglucose-positoron emission tomography and computerized tomography and serum alpha-fetoprotein

2012 ◽  
Vol 38 (3) ◽  
pp. 605-609 ◽  
Author(s):  
Tsukasa Baba ◽  
Saori Su ◽  
Shigeaki Umeoka ◽  
Kaoru Abiko ◽  
Yuji Nakamoto ◽  
...  
Keyword(s):  
Computerized Tomography ◽  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
Emission Tomography ◽  
Yolk Sac Tumor ◽  
Serum Alpha Fetoprotein

scholarly journals Yolk sac tumor in intraabdominal undescended testis in a child with normal serum alpha-fetoprotein: a rare case report

2020 ◽  
Vol 26 (1) ◽  
Author(s):  
Archika Gupta ◽  
Shiv Narain Kureel ◽  
Shalini Bhalla ◽  
Anand Pandey ◽  
Gurmeet Singh ◽  
...  
Keyword(s):  
Abdominal Mass ◽  
Testicular Tumor ◽  
Normal Serum ◽  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
Yolk Sac Tumor ◽  
First Case ◽  
Preoperative Serum ◽  
Serum Alpha Fetoprotein ◽  
Cect Scan

Abstract Background Intraabdominal testicular tumors are rare in prepubertal children, and most of the cases reported are intraabdominal testicular teratoma. The present study reports the first case of intraabdominal testicular yolk sac tumor (YST) with normal preoperative serum alpha-fetoprotein levels and diagnosis confirmed on histopathology and immunohistochemistry. Case Presentation A 2-year-old boy presented with bilateral nonpalpable undescended testes (UDT) and abdominal mass. Preoperative serum alpha-fetoprotein was normal. Contrast-enhanced computed tomography (CECT) scan of whole abdomen revealed a heterogeneous mildly enhancing space-occupying lesion in midline and left side of pelvis, left intraabdominal testis and nonvisualization of right testis. During surgery, the mass was found to involve right testis with one turn of torsion of its pedicle. Derotation of testis was performed, and right radical orchiectomy was performed. Left orchiopexy was also performed at the same time. Histopathology and immunohistochemistry confirmed diagnosis of intraabdominal testicular YST. There was no recurrence or distant metastasis at 12-month follow-up after surgery. Conclusion In a case of nonpalpable UDT and abdominal mass/pain, one should always consider possibility of intraabdominal testicular tumor and should investigate the case with serum tumor markers and ultrasound/CECT abdomen. Further, histology of tumor helps in guiding treatment of condition.

scholarly journals A Case Report of Yolk Sac Tumor in Cerebellar Hemisphere and Review of Literature

2020 ◽  
Author(s):  
Yuting Zhang ◽  
Lusheng Li ◽  
Ling He
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Case Reports ◽  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
Yolk Sac Tumor ◽  
Cerebellar Hemisphere ◽  
Review Of Literature ◽  
Intracranial Germ Cell Tumor ◽  
The Right

Abstract Background: Yolk sac tumor also known as endodermal sinus tumor, is a rare intracranial germ cell tumor. We reported a case of yolk sac tumor in cerebellar hemisphere, and reviewed associated literatures. The majority of tumor locations are near the midline. On review of literature, very few case reports of intracranial yolk sac tumor have been published, and there is only one case report has described a yolk sac tumor arising from the cerebellum. Case presentation: A two years old boy admitted to our hospital due to headache and unsteady gait for six days. CT and MRI demonstrated a tumor in the right cerebellar hemisphere, and the blood and cerebrospinal fluid alpha-fetoprotein were found increased. It was diagnosed as yolk sac tumor after operation comfirmed by histopathological examination. Postoperative chemotherapy was performed, and the patient suffered no tumor recurrence one year and a half after the surgery. Conclusions: The clinical characteristics and imaging diagnosis of intracranial yolk sac tumor are lack of specificity, the comfirmed diagnosis is depending on the combination of elevated alpha-fetoprotein and histopathological examination.

scholarly journals Combined hepatoblastoma and yolk sac tumor of the liver

2020 ◽  
Vol 19 (1) ◽  
pp. 92-99
Author(s):  
M. M. Morozova ◽  
A. V. Varlamov ◽  
O. V. Dolzhansky ◽  
A. V. Filin ◽  
D. S. Burmistrov ◽  
...  
Keyword(s):  
Morphological Structure ◽  
Personal Data ◽  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
Yolk Sac Tumor ◽  
Histological Structure ◽  
Beta Catenin ◽  
Right Lobe ◽  
Mitotic Figures ◽  
The Right

A 6-year-old patient was admitted to the Petrovsky National Research Center of Surgery in Moscow, diagnosed with hepatoblastoma (HB) of the right lobe of the liver and after undergoing 4 cycles of SIOPEL (super PLADO) pre-operative chemotherapy. An immunohistochemistry test, performed after liver resection, revealed a rare combination of mixed epithelial and mesenchymal hepatoblastoma and yolk sac tumor. The epithelial component of HB consisted of highly differentiated fetal cells, while the mesenchymal component consisted of osteoid. The morphological structure of the second lesion corresponded to yolk sac tumor. Both tumors had regressive changes conditioned by chemotherapy: these changes were most pronounced in HB. In the highly differentiated fetal component of HB it was possible to detect a weak focal perinuclear alpha-fetoprotein expression, HepPar expression, membranous expression of beta-catenin and diffuse glutamine synthetase expression. Mitotic figures were not determined. The node of the yolk sac tumor had the characteristic histological structure of an endodermal sinus tumor with a hepatoid component. In the main tumor node and its nodular elements in the fibrovascular stroma it was possible to identify alpha-fetoprotein expression, CD34, nuclear and cytoplasmic expression of beta-catenin, CDX2, as well as a rare expression of PLAP and multi-cytokeratin, and mitotic activity was high (21 in 10 high power fields, 400x magnification). In the existing literature available to us, there is only one observation of combined hepatoblastoma and yolk sac tumor. Parents patients agreed to use personal data, including the fotos, in research and publications.

scholarly journals Tumor Mediastinum Anterior ( Yolk Sac Tumor ) pada Seorang Laki-Laki Dewasa Muda: Sebuah Kasus yang Jarang

2019 ◽  
Vol 2 (2) ◽  
pp. 45
Author(s):  
Risnawati Risnawati ◽  
Laksmi Wulandari
Keyword(s):  
Chest Pain ◽  
Social History ◽  
Malignant Tumors ◽  
Night Sweat ◽  
Yolk Sac ◽  
Alpha Fetoprotein ◽  
Yolk Sac Tumor ◽  
Computed Tomographic ◽  
Morphological Studies ◽  
Β Hcg

Background: Primary mediastinal yolk sac tumor is an extremely rare and highly malignant tumors occuring in children and young adult. They are more common in men. The most common symptoms on ptesentation were dyspnea, chest pain, cought, fever, night sweat, or weight loss. Primary mediastinal tumor are considered to have poor prognosis. Case: A 18- year-old man who presented with shorthness of breath, chest pain, fever, night sweat, and generalized weakness. He had no significant surgical, familiy or social history. The chest X-Ray and computed tomographic scan of the chest showed a large anterior mediasti nal mass. The serum level of alpha- fetoprotein and β-HCG was elevated. The histological examination revealed the finding of yolk sac tumor. This supported the diagnosis of yolk sac tumor. The patient received a combination chemotherapy consisting of cisplatin, etoposide and bleomycin every 3 weeks for total of 4 cycles. Conclusions: Primary mediastinal yolk sac tumor is a rare tumor. The diagnosis should be made not only by morphological studies but the also the patients age and the elevation of serum alpha-fetoprotein. In spite of modern chemotherapy, the prognosis of mediastinal yolk sac tumor remains poor.

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